{"id":10195,"date":"2011-11-23T12:37:03","date_gmt":"2011-11-23T16:37:03","guid":{"rendered":"https:\/\/www.bu.edu\/chemistry\/?p=10195"},"modified":"2012-06-25T15:41:09","modified_gmt":"2012-06-25T19:41:09","slug":"elliott-group-biochemistry-journal","status":"publish","type":"post","link":"https:\/\/www.bu.edu\/chemistry\/2011\/11\/23\/elliott-group-biochemistry-journal\/","title":{"rendered":"Elliott Group Research Featured in Biochemistry"},"content":{"rendered":"<p>The <a title=\"ACS Biochemistry Journal\" href=\"http:\/\/pubs.acs.org\/journal\/bichaw\" target=\"_blank\">Biochemistry Journal<\/a> <a title=\"Flavin-Induced Oligomerization in Escherichia coli Adaptive Response Protein AidB\" href=\"http:\/\/pubs.acs.org\/doi\/full\/10.1021\/bi201340t\" target=\"_blank\">reports<\/a> on research conducted by <a title=\"Professor Sean Elliot's Profile\" href=\"https:\/\/www.bu.edu\/chemistry\/people\/faculty\/elliott\/\" target=\"_blank\">Professor Sean Elliott<\/a> and his <a title=\"The Elliot Research Group @ Boston University\" href=\"http:\/\/people.bu.edu\/elliott\/Welcome.html\" target=\"_blank\">Research Group<\/a> and their collaborators at <a title=\"MIT - Massachusetts Institute of Technology\" href=\"http:\/\/web.mit.edu\/\" target=\"_blank\">MIT<\/a>; <a title=\"Professor Catherine L. Drennan @ MIT\" href=\"http:\/\/www.mit.edu\/~chemistry\/faculty\/drennan.html\" target=\"_blank\">Professor Catherine Drennan<\/a> and her <a title=\"Drennan Research Group @ MIT\" href=\"http:\/\/web.mit.edu\/cld\/\" target=\"_blank\">Research Group<\/a>.<\/p>\n<p>Their research provides strong evidence that <a title=\"Flavin Adenine Dinucleotide \" href=\"http:\/\/en.wikipedia.org\/wiki\/FAD\" target=\"_blank\">Flavin Adenine Dinucleotide<\/a> (FAD) plays a structural role in the formation of tetrameric AidB.  While their studies clearly show FAD-dependent oligomerization of AidB, they do not address whether FAD also has a catalytic function. However, the picture of AidB that is emerging invokes a role for the DNA-binding domain in localization of AidB to specific genes, while the protective function appears to reside elsewhere on the protein.<\/p>\n<p>In future work, the collaborators will investigate  whether this protective function resides with FAD or whether FAD was retained in the evolutionary process solely for its ability to stabilize the AidB tetramer.<\/p>\n<p>This work was supported by <a title=\"NIH\" href=\"http:\/\/www.nih.gov\/\" target=\"_blank\">National Institutes of Health<\/a> Grants R01-GM072663 (to Sean Elliott) and P30-ES002109 (to Catherine Drennan) and National Science Foundation Grant MCB-0543833 (Drennan). Professor Drennan is a <a title=\"HHMI Scientist Bio: Catherine L. Drennan, Ph.D.\" href=\"http:\/\/www.hhmi.org\/research\/investigators\/drennan2_bio.html\" target=\"_blank\">Howard Hughes Medical Institute Investigator<\/a>.<\/p>\n<p>The paper is available at <a title=\"Flavin-Induced Oligomerization in Escherichia coli Adaptive Response Protein AidB\" href=\"http:\/\/pubs.acs.org\/doi\/full\/10.1021\/bi201340t\" target=\"_blank\">http:\/\/pubs.acs.org\/doi\/full\/10.1021\/bi201340t<\/a>, or click on the image below.<\/p>\n<p><a href=\"http:\/\/pubs.acs.org\/doi\/full\/10.1021\/bi201340t\" target=\"_blank\"><img loading=\"lazy\" class=\"aligncenter size-full wp-image-10202\" title=\"Professor Sean Elliot Flavin-Induced Oligomerization \" src=\"\/chemistry\/files\/2011\/11\/sean_elliot_flavin.gif\" alt=\"Professor Sean Elliot Flavin-Induced Oligomerization \" width=\"500\" height=\"218\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Biochemistry Journal reports on research conducted by Professor Sean Elliott and his Research Group and their collaborators at MIT; Professor Catherine Drennan and her Research Group. Their research provides strong evidence that Flavin Adenine Dinucleotide (FAD) plays a structural role in the formation of tetrameric AidB. While their studies clearly show FAD-dependent oligomerization of [&hellip;]<\/p>\n","protected":false},"author":1530,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1529,114,997,63],"tags":[9037,9035,9036,9216,9136],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/posts\/10195"}],"collection":[{"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/users\/1530"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/comments?post=10195"}],"version-history":[{"count":17,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/posts\/10195\/revisions"}],"predecessor-version":[{"id":11351,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/posts\/10195\/revisions\/11351"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/media?parent=10195"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/categories?post=10195"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bu.edu\/chemistry\/wp-json\/wp\/v2\/tags?post=10195"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}