Shu Wang (Class of ’16) and Huijue Lyu (Class of ’19)

In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C–S Lyase and Methyltransferase Reactions Ovothiols are thiolhistidine derivatives. The first step of ovothiol biosynthesis is OvoA-catalyzed oxidative coupling between histidine and cysteine. In this report, the remaining steps of ovothiol A biosynthesis were reconstituted in vitro. ETA_14770 (OvoB) was reported as a PLP-dependent sulfoxide lyase, […]

Shu Wang (Class of ’16)

Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C–S Bond Formation, Li Chen, Nathchar Naowarojna, Heng Song, Shu Wang, Jiangyun Wang, Zixin Deng, Changming Zhao, and Pinghua Liu, Journal of the American Chemical Society 2018 140 (13), 4604-4612 Ovothiol is […]

Melissa Quill (Class of ’19) and Meiling Xu (Class of ’19)

Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis, Nathchar Naowarojna, Ronghai Cheng, Li Chen, Melissa Quill, Meiling Xu, Changming Zhao, and Pinghua Liu, Biochemistry 2018 57 (24), 3309-3325 As one of the most abundant elements on earth, sulfur is part of many small molecular metabolites and is key to their […]