Whitty Lab Paper Chosen as Journal’s “Paper of the Week”

1st Author, Simin Li, Graduate Student in Whitty Group

A publication from the research group of Professor Adrian Whitty has been selected by the Journal of Biological Chemistry (JBC) as “Paper of the Week.” This distinction is conferred upon JBC papers that the Associate Editors and Editorial Board Members consider to represent the “top 2% of JBC papers in overall importance.” The paper, “Quantitative Analysis of Receptor Tyrosine Kinase-Effector Coupling at Functionally Relevant Stimulus Levels,” provides a rare, quantitative view of how activation of a growth factor receptor is linked to signaling and function. The work is significant because it sheds new light on some of the factors that determine what concentration of growth factor is required to achieve a functional response, and how this functional sensitivity relates to the dose-response behavior observed for receptor activation and for intracellular signaling events. The paper also shows that experiments done using high ligand concentrations can obscure quantitative features of receptor signaling. The journal will publish a profile of the paper’s first author, 5th year graduate student Simin Li (pictured). Other Whitty group investigators who contributed to the work include Dr. Devayani Bhave and Dr. Thomas Riera (former Postdoctoral Fellows), Jennifer Chow and Mariya Atanasova (graduate students), Simone Rauch (undergraduate student), and Dr. Richard Cate (Visiting Scientist).