{"id":6684,"date":"2025-09-24T14:34:21","date_gmt":"2025-09-24T18:34:21","guid":{"rendered":"https:\/\/www.bu.edu\/cell-met\/?page_id=6684"},"modified":"2025-09-24T14:40:34","modified_gmt":"2025-09-24T18:40:34","slug":"nordsletten-lab","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/cell-met\/research\/opportunities\/labs-research\/nordsletten-lab\/","title":{"rendered":"Nordsletten Lab"},"content":{"rendered":"<p><a href=\"https:\/\/heart.engin.umich.edu\/about\/\">David Nordsletten<\/a> is a professor at University of Michigan. He received his PhD in Biology from Oxford University.<\/p>\n<p>The Norsdletten lab focuses on the biomechanics and hemodynamics of the heart and cardiovascular system, with particular emphasis on the interface between mechanics and imaging. Current projects include tissue-specific modeling of engineered heart tissues and viscoelasticity and modeling of myocardial and arterial tissues.<\/p>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h2 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Participants<\/h2><div class=\"bu_collapsible_section\" style=\"display: none;\"><br \/>\n\n\t<ul class=\"profile-listing profile-format-basic\">\n\t\t\t\t\t\n<li class=\"profile-item profile-item-basic has-title post-6627 profile type-profile status-publish hentry profile-field-twentytwo profile-field-boston-university profile-field-nordsletten-lab profile-field-past-ret-participant\">\n\t<a href=\"https:\/\/www.bu.edu\/cell-met\/profile\/christopher-carlton\/\" class=\"profile-link profile-link-basic\">\n\t\t\t\t\t<figure class=\"profile-photo profile-photo-basic\"><img width=\"150\" height=\"139\" src=\"\/cell-met\/files\/2023\/05\/Screen-Shot-2023-05-15-at-9.35.21-PM.png\" alt=\"Cartoon silhouette of a person used when a headshot is missing\" \/><\/figure>\t\t\t\t<h6 class=\"profile-name profile-name-basic\">Christopher Carlton<\/h6>\n\t\t<p class=\"profile-title profile-title-basic\">BU RET<\/p>\t<\/a>\n\n\t\n<\/li>\n\t\t\t\t\t\n<li class=\"profile-item profile-item-basic has-title post-6414 profile type-profile status-publish hentry profile-field-twentytwo profile-field-nordsletten-lab profile-field-pastreu profile-field-university-of-michigan\">\n\t<a href=\"https:\/\/www.bu.edu\/cell-met\/profile\/muna-saleh\/\" class=\"profile-link profile-link-basic\">\n\t\t\t\t\t<figure class=\"profile-photo profile-photo-basic\"><img width=\"150\" height=\"150\" src=\"\/cell-met\/files\/2022\/11\/Muna-2-e1759501462826-300x300.jpg\" alt=\"Headshot of Muna Saleh\" \/><\/figure>\t\t\t\t<h6 class=\"profile-name profile-name-basic\">Muna Saleh<\/h6>\n\t\t<p class=\"profile-title profile-title-basic\">UM REU, Norddsletten Lab<\/p>\t<\/a>\n\n\t\n<\/li>\n\t\t\t<\/ul>\n\t<br \/>\n<\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h2 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Projects<\/h2><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<h3>Understanding the Variations in Microtissue Deformations and their Relation with iPSC-CMs Maturity (2023)<\/h3>\n<p><strong>PROJECT DESCRIPTION<\/strong><br \/>\nThe mechanical environment where cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) develop has shown to be an important factor in the degree of function that engineered heart tissues (EHTs) achieve. This was experimentally studied in the so-called fibroTUG setup, where fibers were suspended between two posts, and iPSCs were seeded on top. Traditionally, the mechanical assessment of these tissues is limited to measurements of whole tissue output (measured as post-deformation).<\/p>\n<p>This value is important, but it cannot be used as a proxy of cellular function since the mechanical properties and structure of the extracellular matrix and the structure of the contractile apparatus of the cells (including its density and alignment) will impact how the iPSC-CMs contraction translates to the force output. Therefore, the study of local deformations alongside an understanding of the local tissue structure is key to providing a better assessment of cell function. This project aims to use digital image correlation tools to analyze videos of contractile cardiac microtissues that were grown under different mechanical environments. This will provide essential information that can be used to understand how local deformations are related to experimental observations and as input for computational models that can be used to study tissue mechanics further. The specific research goals were to:<br \/>\n1. Use available software to compute displacement and regional strain values of contractile videos<br \/>\n2. Characterize the deformation pattern per each experimental condition.<br \/>\n3. Correlate these results with biological markers of maturity.<\/p>\n<p><strong>LABORATORY MENTOR<\/strong><br \/>\nJaviera Jilberto Vallejos<\/p>\n<p><strong>LEARNING GOALS<\/strong><br \/>\n\u2022 Use software and coding languages to analyze, compile, and summarize research outputs.<br \/>\n\u2022 Get to know the field of tissue engineering, its challenges and opportunities, and how different disciplines can aid its development.<br \/>\n\u2022 Effectively communicate research motivation, methods, and results to an interdisciplinary audience.<\/p>\n<p><\/div>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>David Nordsletten is a professor at University of Michigan. He received his PhD in Biology from Oxford University. The Norsdletten lab focuses on the biomechanics and hemodynamics of the heart and cardiovascular system, with particular emphasis on the interface between mechanics and imaging. Current projects include tissue-specific modeling of engineered heart tissues and viscoelasticity and [&hellip;]<\/p>\n","protected":false},"author":24547,"featured_media":0,"parent":6835,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/pages\/6684"}],"collection":[{"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/users\/24547"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/comments?post=6684"}],"version-history":[{"count":5,"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/pages\/6684\/revisions"}],"predecessor-version":[{"id":7070,"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/pages\/6684\/revisions\/7070"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/pages\/6835"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/media?parent=6684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}