{"id":6641,"date":"2025-09-24T14:23:23","date_gmt":"2025-09-24T18:23:23","guid":{"rendered":"https:\/\/www.bu.edu\/cell-met\/?page_id=6641"},"modified":"2025-10-03T11:42:49","modified_gmt":"2025-10-03T15:42:49","slug":"he-lab","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/cell-met\/research\/opportunities\/labs-research\/he-lab\/","title":{"rendered":"He Lab"},"content":{"rendered":"<p><a href=\"https:\/\/faculty.fiu.edu\/~jinhe\/\"><img loading=\"lazy\" src=\"\/cell-met\/files\/2018\/10\/jinhe-e1539007985596.jpeg\" alt=\"\" width=\"270\" height=\"270\" class=\" wp-image-1080 alignright\" srcset=\"https:\/\/www.bu.edu\/cell-met\/files\/2018\/10\/jinhe-e1539007985596.jpeg 349w, https:\/\/www.bu.edu\/cell-met\/files\/2018\/10\/jinhe-e1539007985596-150x150.jpeg 150w, https:\/\/www.bu.edu\/cell-met\/files\/2018\/10\/jinhe-e1539007985596-100x100.jpeg 100w\" sizes=\"(max-width: 270px) 100vw, 270px\" \/>Jin He<\/a> is a professor of physics at Florida International University. He received his PhD in biophysics from Arizona State University.<\/p>\n<p>The He Lab studies nanoscale materials and systems, ranging from nanostructured materials to small organic molecule, biomolecules and polymers, individually or at small quantity. He probes or applies these nanoscale materials in controlled and confined nanoscale environments and\/or in complex cellular and tissue environments. One goal of the research is to discover and understand new physics, chemistry or biology phenomena, and properties and functions at nanoscale. The other goal is to transfer the research discoveries into practical devices and tools, and to new applications that are relevant to promoting health and combating disease. To achieve the goal, the lab builds and develops sophisticated instruments to integrate electrical, electrochemical and optical techniques. They also utilize various top-down and bottom-up micro\/nano fabrication techniques to fabricate novel devices.<\/p>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h2 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Participants<\/h2><div class=\"bu_collapsible_section\" style=\"display: none;\"><br \/>\n\n\t<ul class=\"profile-listing profile-format-basic\">\n\t\t\t\t\t\n<li class=\"profile-item profile-item-basic has-title post-6477 profile type-profile status-publish hentry profile-field-eighteen profile-field-nineteen profile-field-bifano-lab profile-field-boston-university profile-field-florida-international-university profile-field-he-lab profile-field-pastreu\">\n\t<a href=\"https:\/\/www.bu.edu\/cell-met\/profile\/antonio-martinez-margolles\/\" class=\"profile-link profile-link-basic\">\n\t\t\t\t\t<figure class=\"profile-photo profile-photo-basic\"><img width=\"150\" height=\"100\" src=\"\/cell-met\/files\/2018\/10\/Antonio-e1759498746787.jpg\" alt=\"Headshot of Antonio Martinez-Margolles\" \/><\/figure>\t\t\t\t<h6 class=\"profile-name profile-name-basic\">Antonio Martinez-Margolles<\/h6>\n\t\t<p class=\"profile-title profile-title-basic\">BU &#038; FIU REU, Bifano &#038; He Lab<\/p>\t<\/a>\n\n\t\n<\/li>\n\t\t\t\t\t\n<li class=\"profile-item profile-item-basic has-title post-6487 profile type-profile status-publish hentry profile-field-nineteen profile-field-florida-international-university profile-field-he-lab profile-field-pastreu\">\n\t<a href=\"https:\/\/www.bu.edu\/cell-met\/profile\/daniel-santana\/\" class=\"profile-link profile-link-basic\">\n\t\t\t\t\t<figure class=\"profile-photo profile-photo-basic\"><img width=\"150\" height=\"102\" src=\"\/cell-met\/files\/2020\/01\/DanielS-e1759506129295.jpg\" alt=\"Headshot of Daniel Santana\" \/><\/figure>\t\t\t\t<h6 class=\"profile-name profile-name-basic\">Daniel Santana<\/h6>\n\t\t<p class=\"profile-title profile-title-basic\">FIU REU, He Lab<\/p>\t<\/a>\n\n\t\n<\/li>\n\t\t\t\t\t\n<li class=\"profile-item profile-item-basic has-title post-6463 profile type-profile status-publish hentry profile-field-eighteen profile-field-nineteen profile-field-florida-international-university profile-field-he-lab profile-field-pastreu profile-field-shtein-lab profile-field-university-of-michigan\">\n\t<a href=\"https:\/\/www.bu.edu\/cell-met\/profile\/melody-siles\/\" class=\"profile-link profile-link-basic\">\n\t\t\t\t\t<figure class=\"profile-photo profile-photo-basic\"><img width=\"120\" height=\"150\" src=\"\/cell-met\/files\/2020\/01\/MeldoyS.jpg\" alt=\"Headshot of Melody Siles\" \/><\/figure>\t\t\t\t<h6 class=\"profile-name profile-name-basic\">Melody Siles<\/h6>\n\t\t<p class=\"profile-title profile-title-basic\">FIU &#038; UM REU, He &#038; Shtein Lab<\/p>\t<\/a>\n\n\t\n<\/li>\n\t\t\t<\/ul>\n\t<br \/>\n<\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h2 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Projects<\/h2><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<h3><span>Fabrication and Characterization of SERS Active Nanopipette for Intracellular Sensing (2019)<\/span><\/h3>\n<p><strong>PROJECT DESCRIPTION<\/strong><br \/>\n<span>This project will fabricate gold nanorod (GNR) coated nanopipette to perform intracellular analysis using surface enhanced Raman spectroscopy(SERS).The specific research goals were to:<\/span><br \/>\n<span>1. Synthesize gold nanorod (GNR) with proper aspect ratio to have adsorption peak around 780 nm.<\/span><br \/>\n<span>2. Successful surface modification of GNR, including silica coating and chemical modification. <\/span><br \/>\n<span>3. Fabrication functional GNR modified nanoipette for SERS measurement.<\/span><br \/>\n<span>4. Work with the graduate student to perform intracellular biosensing using nanopiptte based SERS sensing.<\/span><\/p>\n<p><strong>LABORATORY MENTOR<\/strong><br \/>\n<span>Jing Guo<\/span><\/p>\n<p><strong>LEARNING GOALS<\/strong><br \/>\n<span>1. The synthesis of nanomaterials.<\/span><br \/>\n<span>2. The fabrication of functional nano device<\/span><br \/>\n<span>3. Learn low noise current measurement.<\/span><br \/>\n<span>4. Learn Raman spectroscopy<\/span><br \/>\n<span>5. Learn basic data analysis methods<\/span><br \/>\n<span>6. Learn basic knowledge of nanosensor and cellular biology of cardiomyocyte.<\/span><\/p>\n<hr \/>\n<h3>In situ synthesis of Au nanoparticle film on PDMS for SERS substrate (2018)<\/h3>\n<p><strong>ABSTRACT<\/strong><br \/>\n<strong><\/strong>Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique, which can tell us the chemical structure of examine sample, and it is widely used in biosensing. The advantage of SERS for biosensing is: chemically specific, non-destructive and high sensitivity. However, a challenge in SERS is the fabrication of uniform, reproducible and high enhancement substrate.\u00a0 There are e-beam lithography, nanosphere lithography methods used to solve this problem. Unlike the complicated technique mentioned above, we propose a very simple, large scale and affordable chemical synthesis method. We used gold nanoparticle film (AuNF) on Polydimethylsiloxane (PDMS) film as a substrate to enhance Raman signal. By using AuNF on PDMS, the H2O2 was detected at a concentration of 10 mM.<\/p>\n<p><strong>C<\/strong><strong>ONCLUSIO<\/strong><strong>N<br \/>\n<\/strong>In summary, we developed a flexible, reproductive, and reliable SERS substrate with a high sensitivity at a low cost and can easily be replicable. The SERS substrate can be widely used in biological applications, not only to detect H2O2\u00a0 but to detect other chemicals.<\/p>\n<p><b><img loading=\"lazy\" src=\"\/photonics-reu\/files\/2019\/02\/Screen-Shot-2019-02-13-at-10.32.04-AM.png\" alt=\"\" class=\"alignnone wp-image-2809 size-full\" width=\"3042\" height=\"1872\" \/><\/b><br \/>\n<\/div>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Jin He is a professor of physics at Florida International University. He received his PhD in biophysics from Arizona State University. The He Lab studies nanoscale materials and systems, ranging from nanostructured materials to small organic molecule, biomolecules and polymers, individually or at small quantity. He probes or applies these nanoscale materials in controlled and [&hellip;]<\/p>\n","protected":false},"author":24547,"featured_media":0,"parent":6835,"menu_order":15,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/pages\/6641"}],"collection":[{"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/users\/24547"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/comments?post=6641"}],"version-history":[{"count":7,"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/pages\/6641\/revisions"}],"predecessor-version":[{"id":7192,"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/pages\/6641\/revisions\/7192"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/pages\/6835"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/cell-met\/wp-json\/wp\/v2\/media?parent=6641"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}