T3: Cellular Engineering
Christopher Chen (BU), Team Leader, firstname.lastname@example.org
Christine Seidman (Harvard) email@example.com
Jonathan G. Seidman (Harvard) firstname.lastname@example.org
Gordana Vunjak-Novakovic (Columbia) email@example.com
Cell type Generation
- Generate patient specific iPS cardiomyocytes to capture genetic mutations and natural population variances
- Develop 3D disease models
- Use electro-mechanical stimulation to enhance cardiomyocyte maturation
Measuring contractile Imaging sarcomere Microscale patterning of 2D surfaces to control cell adhesion and shape
function of labeled
myocytes on hydrogels Chopra A. et al.
- Develop nano- and micro-structures, cell-adhesive glues, sensors and actuators designed to support living cells.
- Determine how various materials impact cell contractile function, tissue electrical propagation.
Engineering Cell-Material Interactions and assembly in 3D
Legant W R et al. PNAS 2009
Top (above) and side view (below) of cells
compacting hydrogel to form tissue in
microwells with pillars
An image of stained engineered cardiac tissues
- Spatially control the adhesion of cells to materials using nano-adhesive and nano-topographies in 3D to form complex biomimetic architectures.
- Investigate cell alignment and contractile behavior of engineered constructs.