{"id":3328,"date":"2019-04-26T11:37:04","date_gmt":"2019-04-26T15:37:04","guid":{"rendered":"https:\/\/www.bu.edu\/cbr\/?page_id=3328"},"modified":"2024-05-14T15:24:27","modified_gmt":"2024-05-14T19:24:27","slug":"neural-markers","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/cbr\/research\/neural-markers\/","title":{"rendered":"Neuroimaging Biomarkers"},"content":{"rendered":"<div class=\"article-outer\">\n<div id=\"Neuroimaging-Biomarkers\" class=\"article-inner\">\n<div class=\"bu-slideshow-container neuroimagingbiomarkers autoplay\" id=\"bu-slideshow-container-5961\" data-slideshow-name=\"neuroimagingbiomarkers\" data-slideshow-delay=\"5000\" style=\"width: auto; \"><div class='slideshow-loader active'><div class='loader-animation'><\/div><p>loading slideshow...<\/p><\/div><div class=\"bu-slideshow-slides\"><ul class=\"bu-slideshow transition-slide\" id=\"bu-slideshow-5961\"><li id=\"bu-slideshow-5961_0\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/cbr\/files\/2023\/06\/1-636x358.png\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-right\"><p class=\"bu-slide-caption-title\">Process<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-5961_1\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/cbr\/files\/2023\/06\/2-636x358.png\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-right\"><p class=\"bu-slide-caption-title\">What constitutes neural recovery in aphasia?<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-5961_2\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/cbr\/files\/2023\/06\/3-636x358.png\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-right\"><p class=\"bu-slide-caption-title\">Theory of recovery in chronic aphasia<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-5961_3\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/cbr\/files\/2023\/06\/4-636x358.png\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-right\"><p class=\"bu-slide-caption-title\">Language recovery in person with aphasia<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-5961_4\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/cbr\/files\/2023\/06\/5-636x358.png\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-right\"><p class=\"bu-slide-caption-title\">Regions<\/p><\/div><\/div><\/li><\/ul><\/div><div class=\"bu-slideshow-navigation-container\"><ul class=\"bu-slideshow-navigation nav-icon\" id=\"bu-slideshow-nav-5961\" aria-hidden=\"true\"><li><a href=\"#\" id=\"pager-1\" class=\" active\" aria-hidden=\"true\"><span>1<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-2\" class=\"\" aria-hidden=\"true\"><span>2<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-3\" class=\"\" aria-hidden=\"true\"><span>3<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-4\" class=\"\" aria-hidden=\"true\"><span>4<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-5\" class=\"\" aria-hidden=\"true\"><span>5<\/span><\/a><\/li> <\/ul><\/div><\/div>\n<p>Recent advances in neuroimaging techniques have enhanced our understanding of neural plasticity and brain reorganization after stroke for people with aphasia. Some of our studies in the lab seek to evaluate the functional and structural changes in the brain that can be observed in patients with language impairment as a result of stroke and over the course of treatment and recovery.<\/p>\n<p>We accomplish this by employing a variety of the most current neuroimaging techniques to examine and track changes in neural biomarkers. Recent and current studies in our lab have included the use of functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI) and functional near-infrared spectroscopy (fNIRS).\u00a0In one line of research,\u00a0we analyze differences in patterns of brain activation during language tasks, non-linguistic cognitive tasks and at rest.\u00a0In addition, structural imaging data enable us to examine consequences of stroke on the anatomy of neural networks and on brain tissue health, at and beyond the lesion.<\/p>\n<p>The investigation of structural and functional connectivity, as well as\u00a0overall brain health, will help us predict treatment outcomes and better understand inter-individual variability in language recovery from acute to chronic stages. Our aim is to create new models that will improve personalization and treatment effects for people with aphasia by characterizing neurophysiological factors that affect recovery of language abilities.<\/p>\n<h2>Ongoing Studies<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.bu.edu\/cbr\/2023\/06\/14\/spotlight-research-multiple-demand-study\/\">Multiple Demand Network (MD Study)<\/a><\/li>\n<li><a href=\"https:\/\/www.bu.edu\/aphasiaresearch\/research\/neural-markers\/white-matter-connectivity\/\" target=\"_blank\" rel=\"noopener noreferrer\">White Matter Connectivity<\/a><\/li>\n<li><a href=\"https:\/\/www.bu.edu\/aphasiaresearch\/research\/neural-markers\/small-vessel-disease-treatment-outcome-in-aphasia\/\" target=\"_blank\" rel=\"noopener noreferrer\">Small Vessel Disease (SVD)<\/a><\/li>\n<li><a href=\"https:\/\/www.bu.edu\/aphasiaresearch\/research\/neural-markers\/predicting-typicality-effect-from-individual-brain-activity-patterns-in-healthy-subjects-multi-voxel-pattern-analysis-mvpa\/\" target=\"_blank\" rel=\"noopener noreferrer\">Multi-Voxel Pattern Analysis (MVPA)<\/a><\/li>\n<li><a href=\"https:\/\/www.bu.edu\/aphasiaresearch\/research\/effective-treatments\/projects-on-language-recovery\/\" target=\"_blank\" rel=\"noopener noreferrer\">Projects on Language Recovery Using fMRI<\/a><\/li>\n<li><span>Voxel-Based Lesion-Symptom Mapping Applied to Calculation Performance in Aphasic Patients<\/span><\/li>\n<\/ul>\n<h2>Recent Publications and Presentations<\/h2>\n<p><span style=\"font-weight: 400;\">Gu, Y., Bahrani, M., Billot, A., Lai, S., <\/span><b>Braun, E. J.<\/b><span style=\"font-weight: 400;\">, Varkanitsa, M., Bighetto, J., Rapp, B., Parrish, T. B., Caplan, D., Thompson, C. K., Kiran, S., &amp; Betke, M. (2020, June). A machine learning approach for predicting post-stroke aphasia recovery: A pilot study. Paper presented at PETRA \u201920: The 13<\/span><span style=\"font-weight: 400;\">th<\/span><span style=\"font-weight: 400;\"> PErvaseive Technologies Related to Assistive Environments Conference (PETRA), Virtual. DOI: <\/span><span style=\"font-weight: 400;\">10.1145\/3389189.3389204<\/span><\/p>\n<p style=\"margin-bottom: 0;\"><span style=\"font-weight: 400;\">Billot, A., Lai, S., Varkanitsa, M., <\/span><b>Braun, E. J.<\/b><span style=\"font-weight: 400;\">, Gu, Y., Bahrani, M., Bighetto, J., Rapp, B., Parrish, T. B., Caplan, D., Thompson, C. K., Betke, M., &amp; Kiran, S. (2020, October). Predicting post-stroke aphasia recovery from multimodal neuroimaging data.\u00a0Oral presentation at the 11<\/span><span style=\"font-weight: 400;\">th<\/span><span style=\"font-weight: 400;\"> World Congress for Neurorehabilitation, Virtual.<\/span><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Recent advances in neuroimaging techniques have enhanced our understanding of neural plasticity and brain reorganization after stroke for people with aphasia. Some of our studies in the lab seek to evaluate the functional and structural changes in the brain that can be observed in patients with language impairment as a result of stroke and over [&hellip;]<\/p>\n","protected":false},"author":15716,"featured_media":0,"parent":6,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/cbr\/wp-json\/wp\/v2\/pages\/3328"}],"collection":[{"href":"https:\/\/www.bu.edu\/cbr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/cbr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cbr\/wp-json\/wp\/v2\/users\/15716"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cbr\/wp-json\/wp\/v2\/comments?post=3328"}],"version-history":[{"count":32,"href":"https:\/\/www.bu.edu\/cbr\/wp-json\/wp\/v2\/pages\/3328\/revisions"}],"predecessor-version":[{"id":6093,"href":"https:\/\/www.bu.edu\/cbr\/wp-json\/wp\/v2\/pages\/3328\/revisions\/6093"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/cbr\/wp-json\/wp\/v2\/pages\/6"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/cbr\/wp-json\/wp\/v2\/media?parent=3328"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}