{"id":5247,"date":"2022-07-14T11:54:13","date_gmt":"2022-07-14T15:54:13","guid":{"rendered":"https:\/\/www.bu.edu\/bump\/?post_type=profile&#038;p=5247"},"modified":"2024-11-21T13:14:26","modified_gmt":"2024-11-21T18:14:26","slug":"cynthia-bradham","status":"publish","type":"profile","link":"https:\/\/www.bu.edu\/bump\/people\/cynthia-bradham\/","title":{"rendered":"Cynthia A. Bradham"},"content":{"rendered":"<p><a href=\"https:\/\/people.bu.edu\/cbradham\/index.html\"><strong>Research Website<\/strong><\/a><\/p>\n<p><a href=\"https:\/\/scholar.google.com\/citations?user=xQat4DQAAAAJ&amp;hl=en\"><strong>Google Scholar Profile<\/strong><\/a><\/p>\n<p><strong>Courses Taught<\/strong><\/p>\n<ul>\n<li>BI410: Developmental Biology<\/li>\n<\/ul>\n<p><strong>Current Research<\/strong><\/p>\n<p><span>Our research is focused on understanding secondary (dorsal-ventral) axis specification and skeletal patterning in the sea urchin. We are interested in producing a systems-level description for these processes. Sea urchin, a non-chordate deuterostome, is an ideal model organism for systems-level developmental studies. Genomic analysis has revealed that sea urchins share the diversity of signaling and transcriptional molecules with vertebrates, including humans, but lack the complexity associated with a duplicated genome. Further, sea urchin larvae are morphologically quite simple, being composed of approximately 15 cell types, and thus are accessible to detailed analysis of cell specification and cell-cell communication mechanisms. Finally, the use of gene regulatory networks to model developmental processes was pioneered in urchin, providing a strong precedent for this work. The lab is focused primarily on two projects: understanding how the dorsal-ventral axis is specified, and how the larval skeleton is patterned. We are pursuing these projects through a combination of molecular biology, biochemistry, cell biology, computational modeling, and systems biology approaches.<\/span><\/p>\n","protected":false},"author":2970,"template":"","_links":{"self":[{"href":"https:\/\/www.bu.edu\/bump\/wp-json\/wp\/v2\/profile\/5247"}],"collection":[{"href":"https:\/\/www.bu.edu\/bump\/wp-json\/wp\/v2\/profile"}],"about":[{"href":"https:\/\/www.bu.edu\/bump\/wp-json\/wp\/v2\/types\/profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/bump\/wp-json\/wp\/v2\/users\/2970"}],"version-history":[{"count":8,"href":"https:\/\/www.bu.edu\/bump\/wp-json\/wp\/v2\/profile\/5247\/revisions"}],"predecessor-version":[{"id":6079,"href":"https:\/\/www.bu.edu\/bump\/wp-json\/wp\/v2\/profile\/5247\/revisions\/6079"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/bump\/wp-json\/wp\/v2\/media?parent=5247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}