{"id":32,"date":"2012-08-28T11:22:02","date_gmt":"2012-08-28T15:22:02","guid":{"rendered":"https:\/\/www.bu.edu\/botlab\/?page_id=32"},"modified":"2026-06-07T15:16:42","modified_gmt":"2026-06-07T19:16:42","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/botlab\/publications\/","title":{"rendered":""},"content":{"rendered":"

Peer Reviewed Publications:<\/h4>\n

2026<\/strong>
\nAarohi Mahesh Mehendale, Darren Roblyer NIH funding in the biophotonics community,<\/em> Biophotonics Discovery 3(2), 020601 (5 Jun 2026) link<\/a><\/p>\n

Diana Suciu, Thao Pham, Lina Lin Wei, Isaac Hoekstra, Pranav Yadati, Vipul C. Chitalia, Darren Roblyer, Frequency-domain broadband near-infrared spectroscopy for noninvasive monitoring of fluid volume status during hemodialysis.<\/em> Biophoton. Discovery 3(1) 015003 (4 February 2026) link<\/a><\/p>\n

2025<\/strong><\/p>\n

Darren Roblyer, Anahita Pilvar, Thao Pham, Sam Spink, Carole K. Hayakawa, Vasan Venugopalan, and Mark C. Pierce, Review of shortwave infrared imaging and spectroscopy in tissue [Invited].<\/em> Biomed. Opt. Express 16, 5028-5062 (2025) link<\/a><\/p>\n

Ariane Garrett, Ana Perez, Rivka Ayalon, John Forman, Naomi Hamburg, David Boas, Darren Roblyer, Optical methods for cuffless blood pressure measurements.<\/em> Biophoton. Discovery 3(1) 010901 (31 October 2025) link<\/a><\/p>\n

Ariane Garrett, Byungchan Kim, Nil Z. Gurel, Edbert J. Sie, Benjamin K. Wilson, Francesco Marsili, John P. Forman, Naomi M. Hamburg, David A. Boas, and Darren Roblyer, Speckle contrast optical spectroscopy for cuffless blood pressure estimation based on microvascular blood flow and volume oscillations.<\/em> Biomed. Opt. Express 16, 3004-3016 (2025) link<\/a><\/p>\n

Mahsa Parsanasab, Aarohi M. Mehendale, Kavon Karrobi, Darren M. Roblyer, Vasan Venugopalan, Structured light imaging mesoscopy: detection of embedded morphological changes in superficial tissues.<\/em> J. Biomed. Opt. 30(6) 065001 (18 June 2025), link<\/a> <\/p>\n

Aarohi Mahesh Mehendale, Mahsa Parsanasab, Kavon Karrobi, Hung Vo, Andreea M. Bujor, Vasan Venugopalan, Darren Roblyer,Structured light imaging mesoscopy: application to skin changes in sclerodermam.<\/em> Biophotonics Discovery 2(2) 025002 (18 June 2025), link<\/a> <\/p>\n

Diana Suciu, Thao Pham, Lina Lin Wei, Shripreetika Guruprasad, Darren Roblyer, Frequency domain broadband short-wave infrared spectroscopy for measurement of tissue optical properties from 685 to 1300 nm.<\/em> J. Biomed. Opt. 30(4), 045001 (2025), link<\/a> <\/p>\n

Livecchi TT, Jacques SL, Pilvar A, Roblyer D and Pierce MC, Shortwave infrared spatial frequency domain imaging for detection of changes in tissue hydration<\/em>. Frontiers in Photonics, 6:1546952 (2025), link<\/a> <\/p>\n

2024<\/strong><\/p>\n

Carlos A. G\u00f3mez, Darren Roblyer, \u201cEffects of skin tone and adipose thickness on frequency domain near infrared spectroscopy and diffuse correlation spectroscopy\u201d<\/em>, Biophotonics Discovery, 2(1), 012503 (2024), link<\/a> <\/p>\n

Shuqi Zheng, Ian Davison, Ariane Garrett, Darren Roblyer, Jerome Mertz, \u201cRobust speckle contrast imaging based on spatial covariance\u201d<\/em>, Optica, 11, 1733-1741 (2024), link<\/a> <\/p>\n

Ariane Garrett, Byungchan Kim, Nil Z. Gurel, Edbert J. Sie, Benjamin K. Wilson, Francesco Marsili, John P. Forman, Naomi M. Hamburg, David A. Boas, Darren Roblyer, \u201cSpeckle contrast optical spectroscopy improves cuffless blood pressure estimation compared to photoplethysmography\u201d<\/em>, bioRxiv 2024.08.16.608163; link<\/a> <\/p>\n

Anahita Pilvar, Jorge Plutzky, Darren Roblyer, \u201cEnhanced peripheral tissue oxygenation and hemoglobin concentration after a high-fat meal measured with spatial frequency domain imaging\u201d<\/em>, Biophotonics Discovery, 1(2), 025004 (2024), link<\/a><\/p>\n

Thao Pham, Lina Lin Wei, Darren Roblyer, \u201cCross-wavelength Calibrating Method for Real-time Imaging of Tissue Optical Properties using Frequency-Domain Diffuse Optical Spectroscopy,\u201d<\/em> Biomed. Opt. Express, 15, 4963-4979 (2024) link<\/a><\/p>\n

Antenor Rodrigues, Kazuya Shingai, Carlos A. G\u00f3mez, Peter Rassam, Dmitry Rozenberg, Ewan Goligher, Laurent Brochard, Darren Roblyer, W. Darlene Reid, \u201cContinuous measurements of respiratory muscle blood \ufb02ow and oxygen consumption using non-invasive frequency domain near-infrared spectroscopy and di\ufb00use correlation spectroscopy,\u201d<\/em> Journal of Applied Physiology, , 2024 Aug 1;137(2):382-393, link<\/a><\/p>\n

Ran Tao, Janek Gr\u00f6hl, Lina Hacker, Antonio Pifferi, Darren Roblyer, Sarah E. Bohndiek, \u201cTutorial on methods for estimation of optical absorption and scattering properties of tissue,\u201d<\/em> J. Biomed. Opt. 29(6), 060801 (2024), link<\/a> <\/p>\n

Carlos A. G\u00f3mez, Laurent Brochard, Ewan C. Goligher, Dmitry Rozenberg, W. Darlene Reid, Darren Roblyer, \u201cA combined frequency domain near infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading,\u201d<\/em> J. Biomed. Opt. 29(3), 035002 (2024), link<\/a> <\/p>\n

2023<\/strong><\/p>\n

S Zhang, G Grifno, R Passaro, K Regan, S Zheng, M Hadzipasic, R Banerji, L O\u2019Connor, V Chu, S Kim, J Yang, L Shi, K Karrobi*, Darren Roblyer, M Grinstaff, H Nia, “Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission,”<\/em> Nat. Biomed. Eng (2023), link<\/a><\/p>\n

Samuel S. Spink, Anahita Pilvar, Lina Lin Wei, Jodee Frias, Kylee Anders, Sabrina T. Franco, Olivia Claire Rose, Megan Freeman, Grace Bag, Huiru Huang, Darren Roblyer, “Shortwave infrared diffuse optical wearable probe for quantification of water and lipid content in emulsion phantoms using deep learning,”<\/em> J. Biomed. Opt. 28(9) 094808 (12 June 2023), link<\/a><\/p>\n

Anahita Pilvar, Declan W. Smith, Jorge Plutzky, Darren Roblyer, “Feasibility of postprandial optical scattering of lipoproteins in blood as an optical marker of cardiovascular disease risk: modeling and experimental validation,”<\/em> J. Biomed. Opt. 28(6), 065002 (2023), link<\/a><\/p>\n

Anahita Pilvar, Aarohi M. Mehendale, Kavon Karrobi, Fatima El-Adili, Andreea Bujor, and Darren Roblyer, “Spatial frequency domain imaging for the assessment of scleroderma skin involvement,”<\/em> Biomed. Opt. Express 14, 2955-2968 (2023), link<\/a><\/p>\n

Ariane Garrett, Byungchan Kim, Edbert J. Sie, Nil Z. Gurel, Francesco Marsili, David A. Boas, and Darren Roblyer, “Simultaneous photoplethysmography and blood flow measurements towards the estimation of blood pressure using speckle contrast optical spectroscopy”<\/em>, Biomed. Opt. Express 14, 1594-1607 (2023), link<\/a><\/p>\n

Kavon Karrobi, Anup Tank, Mohammad Ahsan Fuzail, Madhumathi Kalidoss, Karissa Tilbury, Muhammad Zaman, Jacopo Ferruzzi, Darren Roblyer, \u201cFluorescence Lifetime Imaging Microscopy (FLIM) reveals spatial\u2011metabolic changes in 3D breast cancer spheroids\u201d<\/em>, Scientific Reports, 13:3624 (2023), link<\/a><\/p>\n

2022<\/strong><\/p>\n

Anahita Pilvar, Jorge Plutzky, Mark C. Pierce, Darren Roblyer, \u201cShortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties\u201d<\/em>, Journal of Biomedical Optics, 27(6), 066003 (2022), link<\/a><\/p>\n

Cameron Vergato, Kshama A. Doshi, Darren Roblyer, David J. Waxman, \u201cType-I interferon signaling is essential for robust metronomic chemo-immunogenic tumor regression in murine breast cancer\u201d<\/em>, Cancer Research Communications (2022), 2 (4): 246-257, link<\/a><\/p>\n

Tank, A., Vergato, C., Waxman, D.J., Darren Roblyer, \u201cSpatial frequency domain imaging for monitoring immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model.\u201d<\/em> Sci Rep 12, 5864 (2022). link<\/a><\/p>\n

2021<\/strong><\/p>\n

Kang, W., Ferruzzi, J., Spatarelu, C.-P., Han, Y.L., Sharma, Y., Koehler, S.A.,Mitchel, J.A., Khan, A., Butler, J.P., Darren Roblyer, Zaman, M.H., Park, J.-A., Guo, M., Chen, Z., Pegoraro,A.F., Fredberg, J.J., “A novel jamming phase diagram links tumor invasion to non-equilibrium phaseseparation,”<\/em> iSCIENCE (2021) link<\/a><\/p>\n

Samer Bou Jawde, Kavon Karrobi*, Darren Roblyer, Francesco Vicario, Jacob Herrmann, Dylan Casey, Kenneth R. Lutchen, Dimitrije Stamenovi\u0107, Jason H. T. Bates, B\u00e9la Suki, “Inflation instability in the lung: an analytical model of a thick-walled alveolus with wavy fibres under large deformations,”<\/em> J. R. Soc. Interface 18: 20210594. (2021) link<\/a><\/p>\n

Raeef Istfan, Carlos A. G\u00f3mez, Matthew Applegate, Dmitry Rozenberg, W. Darlene Reid, Darren Roblyer, “Hemodynamics of the sternocleidomastoid measured with frequency domain near-infrared spectroscopy towards non-invasive monitoring during mechanical ventilation,”<\/em> Biomedical Optics Express 12, 4147-4162 (2021) link<\/a><\/p>\n

Samuel S. Spink, Fei Teng, Vivian Pera, Hannah M. Peterson, Tim Cormier, Alexis Sauer-Budge, David Chargin, Sam Brookfield, Adam Eggebrecht, Naomi Ko, Darren Roblyer, \u201cA high optode-density wearable diffuse optical probe for monitoring paced breathing hemodynamics in breast tissue,\u201d<\/em> Journal of Biomedical Optics, 26(6) 062708 (2 June 2021) link<\/a><\/p>\n

M Applegate, R Amelard, C Gomez, Darren Roblyer, “Real-time handheld probe tracking and image formation using digital frequency-domain diffuse optical spectroscopy,”<\/em> IEEE Transactions on Biomedical Engineering link<\/a><\/p>\n

M Applegate, C G\u00f3mez, Darren Roblyer, “Modulation frequency selection and efficient look-up table inversion for frequency domain diffuse optical spectroscopy,”<\/em> Journal of Biomedical Optics. 26(3) 036007 (25 March 2021) link<\/a><\/p>\n

S Tabassum, A Tank, F Wang, K Karrobi, C Vergato, IJ Bigio, DJ Waxman, Darren Roblyer \u201cOptical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer.\u201d<\/em> Neoplasia, 23(3), 294-303 (2021) link<\/a><\/p>\n

M Applegate, S Spink, Darren Roblyer \u201cDual-DMD hyperspectral spatial frequency domain imaging (SFDI) using dispersed broadband illumination with a demonstration of blood stain spectral monitoring.\u201d<\/em> Biomedical Optics Express, 12, 676-688 (2021) link<\/a> <\/p>\n

2020<\/strong><\/p>\n

Y Zhao, A Pilvar, A Tank, H Petterson, J Jiang, JC Aster, JP Dumas, MC Pierce, Darren Roblyer, \u201cShortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content.\u201d<\/em> Nature Communications 11, 5355 (2020). link<\/a><\/p>\n

Sunil S, Evren Erdener S, Cheng X, Kura S, Tang J, Jiang J, Karrobi K, K\u0131l\u0131\u00e7 K, Darren Roblyer, Boas DA. \u201cStroke core revealed by tissue scattering using spatial frequency domain imaging\u201d.<\/em> Neuroimage Clin. 2020 Dec 20;29:102539. PMID: 33385882. link<\/a><\/p>\n

Stephen J. DeCamp, Victor M. K. Tsuda, Jacopo Ferruzzi, Stephan A. Koehler, John T. Giblin, Darren Roblyer, Muhammad H. Zaman, Scott T. Weiss, Ay\u015fe K\u0131l\u0131\u00e7, Margherita De Marzio, Chan Young Park, Nicolas Chiu Ogassavara, Jennifer A. Mitchel, James P. Butler & Jeffrey J. Fredberg \u201cEpithelial layer unjamming shifts energy metabolism toward glycolysis\u201d<\/em>. Scientific Reports 10, 18302 (2020). link<\/a><\/p>\n

Darren Roblyer, “Perspective on the increasing role of optical wearables and remote patient monitoring in the COVID-19 era and beyond,”<\/em> J. Biomed. Opt. 25(10) 102703 (21 October 2020). link<\/a><\/p>\n

Hannah M. Peterson, Anup Tank, David S. Geller, Rui Yang, Richard Gorlick, Bang H. Hoang, Darren Roblyer, “Characterization of bony anatomic regions in pediatric and adult healthy volunteers using diffuse optical spectroscopic imaging,”<\/em> Journal of Biomedical Optics 25(8), 086002 (2020). link<\/a><\/p>\n

MB Applegate, R Istfan, S Spink, A Tank, and Darren Roblyer “Recent advances in high speed diffuse optical imaging in biomedicine,”<\/em> APL Photonics, 5, 040802 (2020). link<\/a><\/p>\n

Anup Tank, Hannah M. Peterson, Vivian Pera, Syeda Tabassum, Anais Leproux, Thomas O\u2019Sullivan, Eric Jones, Howard Cabral, Naomi Ko, Rita S. Mehta, Bruce J. Tromberg, Darren Roblyer “Diffuse optical spectroscopic imaging reveals distinct early breast tumor hemodynamic responses to metronomic and maximum tolerated dose regimens,”<\/em> Breast Cancer Research 22, 29 (2020). link<\/a><\/p>\n

MB Applegate, K Karrobi, JP Angelo Jr., WM Austin, S Tabassum, E Agu\u00e9nounon, K Tilbury, R Saager, S Gioux, Darren Roblyer, “OpenSFDI: an open-source guide for constructing a spatial frequency domain imaging system,”<\/em> Journal of Biomedical Optics, 25(1) 016002 (2020) link<\/a><\/p>\n

2019<\/strong><\/p>\n

J Ferruzzi,M Sun, A Gkousioudi, A Pilvar, Darren Roblyer, Y Zhang, MH Zaman, \u201cCompressive Remodeling Alters Fluid Transport Properties of Collagen Networks \u2013 Implications for Tumor Growth,\u201d<\/em> Scientific Reports, 9, 17151 (2019) link<\/a><\/p>\n

K Karrobi, A Tank, V Pera, Darren Roblyer, \u201cDiffuse and nonlinear imaging of multiscale vascular parameters for in vivo monitoring of preclinical mammary tumors,\u201d<\/em> Journal of Biophotonics, (2019) link<\/a><\/p>\n

B Bungart, Y Cao, T Yang-Tran, S Gorsky, L Lan, Darren Roblyer, M O.Kock, L Cheng, T Masterson, Ji-Xin Cheng \u201cCylindrical illumination with angular coupling for whole-prostate photoacoustic tomography\u201d<\/em>, Biomedical Optics Express, 10(3), 1405-1419 (2019) link<\/a><\/p>\n

2018<\/strong><\/p>\n

Y Zhao, Y Deng, F Bao, Darren Roblyer , \u201cA deep learning model for ultrafast multi-frequency optical property extractions for Spatial Frequency Domain Imaging (SFDI),\u201d<\/em> Optics Letters, 15;43(22):5669-5672.(2018) link<\/a><\/p>\n

Y Zhao*, M Applegate*, R Istfan, A Pande, Darren Roblyer , \u201cQuantitative real-time pulse oximetry with ultrafast frequency-domain diffuse optics and deep neural network processing,\u201d<\/em> Biomedical Optics Express, 9(12), 5997-6008 (2018). *shared first-authors link<\/a><\/p>\n

JM Cochran, DR Busch, A Leproux, Z Zhang, TD O\u2019Sullivan, AE Cerussi, PM Carpenter, R Mehta, Darren Roblyer, W Yang, KD Paulsen, B Pogue, S Jiang, PA Kaufman, SH Chung, M Schnall, BS Snyder, N Hylton, SA Carp, SJ Isakoff, D Mankoff, B Tromberg, AG Yodh, \u201cTissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment,\u201d<\/em> Journal of Biomedical Optics, 24(2), 0212025 (2018). link<\/a><\/p>\n

CK Hayakawa, K Karrobi, V Pera, Darren Roblyer, V Venugopalan, \u201cOptical sampling depth in the spatial frequency domain,\u201d<\/em> Journal of Biomedical Optics, 23(8), 085005 (2018). link<\/a><\/p>\n

S Tabassum, V Pera, G Greening, T Muldoon, Darren Roblyer, \u201cTwo-layer inverse model for improved longitudinal preclinical tumor imaging in the spatial frequency domain,\u201d<\/em> Journal of Biomedical Optics, 23(7), 076011 (2018). link<\/a><\/p>\n

V Pera, K Karrobi, S Tabassum, F Teng, Darren Roblyer, \u201cOptical property uncertainty estimates for spatial frequency domain imaging,\u201d<\/em> Biomedical Optics Express, 9(2), 661-678 (2018) link<\/a><\/p>\n

M Applegate, Darren Roblyer, \u201cMulti-distance diffuse optical spectroscopy with a single optode via hypotrochoidal scanning,\u201d<\/em> Optics Letters, 43(4), 747-750 (2018) link<\/a><\/p>\n

2017<\/strong><\/p>\n

H Peterson, B.H. Hong, D Geller, R Yang, R Gorlick, J Berger, J Tingling, M Roth, J Gill, Darren Roblyer, \u201cIn vivo, non-invasive functional measurements of bone sarcoma using diffuse optical spectroscopic imaging,\u201d<\/em> Journal of Biomedical Optics, 22(12), 121612 (2017) link<\/a><\/p>\n

M Applegate, Darren Roblyer, \u201cHigh-speed Spatial Frequency Domain Imaging (SFDI) with temporally modulated light,\u201d<\/em> Journal of Biomedical Optics, 22(7), 076019 (2017) link<\/a><\/p>\n

A Leproux, TD. O\u2019Sullivan, A Cerussi, Durkin A,Hill B, Hylton N, Yodh A, Carp S, Boas D, Jiang S, Pogue B, Darren Roblyer, Tromberg, B \u201cPerformance assessment of diffuse optical spectroscopic imaging instruments in a two-year, multicenter breast cancer trial,\u201d<\/em> Journal of Biomedical Optics, 22(12), 021604 (August 17, 2017) link<\/a><\/p>\n

A. Torjesen, R Istfan, Darren Roblyer, \u201cUltrafast wavelength multiplexed broad bandwidth digital diffuse optical spectroscopy for in vivo extraction of tissue optical properties,\u201d<\/em> Journal of Biomedical Optics, 22(3), 036009 (2017)\u00a0link<\/a><\/p>\n

F Teng, T Cormier, A Sauer-Budge, R Chaudhury, V Pera, D Chargin, S Brookfield, N Yu Ko, Darren Roblyer, \u201cWearable near-infrared optical probe for continuous monitoring during breast cancer neoadjuvant chemotherapy infusions,\u201d<\/em> Journal of Biomedical Optics, 22(1), 014001 (Jan 13, 2017)\u00a0link<\/a><\/p>\n

2016<\/strong><\/p>\n

S Tabassum, Y Zhao, R Istfan, J Wu, DJ Waxman, Darren Roblyer, \u201cFeasibility of spatial frequency domain imaging (SFDI) for optically characterizing a preclinical oncology model,\u201d<\/em> Biomedical Optics Express 7(10), 4154-4170 (2016)\u00a0link<\/a><\/span><\/p>\n

B Tromberg, Z Zhang, A Leproux, TD. O\u2019Sullivan, A Cerussi, P Carpenter, R Mehta, Darren Roblyer, W Yang , KD Paulsen, BW Pogue, S Jiang, P Kaufman, A Yodh, S Chung, M Schnall, B Snyder, N Hylton, D Boas, S Carp, S Isakoff, D Mankoff, \u201cPredicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging (DOSI),\u201d<\/em> Cancer Research, 2016 \u00a0link<\/a><\/p>\n

Y Zhao, S Tabassum, S Piracha, M Sobhana Nandhu, M Viapiano, and Darren Roblyer,“Angle correction for small animal tumor imaging with spatial frequency domain imaging (SFDI),”<\/em> Biomedical Optics Express 7(6), 2373-2384 (2016)\u00a0link<\/a><\/p>\n

2015<\/strong><\/p>\n

P Diep, S Pannem, J Sweer, J Lo, M Snyder, G Stueber, Y Zhao, S Tabassum, R Istfan, J Wu, S Erramilli, Darren Roblyer, \u201cThree-dimensional printed optical phantoms with customized absorption and scattering properties,”<\/em> Biomedical Optics Express, 2015 Oct; 6(11)\u00a0link<\/a><\/p>\n

Y Zhao, Darren Roblyer, \u201cSpatial mapping of fluorophore quantum yield in diffusive media,\u201d<\/em> Journal of Biomedical Optics, 2015 Aug; 20(8) 086013.\u00a0link<\/a><\/p>\n

2014<\/strong><\/p>\n

J Jung, R Istfan, Darren Roblyer, \u201cNote: A simple broad bandwidth undersampling frequency-domain digital diffuse optical spectroscopy system,\u201d<\/em> Review of Scientific Instruments, 2014 July; 85 link<\/a><\/p>\n

R.P. Singh-Moon, Darren Roblyer, I.J. Bigio, S.Joshia, \u201cSpatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency domain imaging,\u201d<\/em> Journal of Biomedical Optics, 2014 Aug; 19(9) link<\/a><\/p>\n

G Greening, R Istfan, L Higgins, K Balachandran, Darren Roblyer, M Pierce, TJ Muldoon, \u201cCharacterization of thin poly(dimethylsiloxane)-based tissue-simulating phantoms with tunable reduced scattering and absorption coefficients in the visible to near-infrared domain,\u201d<\/em> Journal of Biomedical Optics, 2014 Sept; 19(11) 115002<\/span> link<\/a><\/p>\n

2013<\/strong><\/p>\n

Darren Roblyer, T O\u2019Sullivan, R.V. Warren, BJ Tromberg, \u201cFeasibility of direct digital sampling for disuse optical frequency domain spectroscopy in tissue,\u201d<\/em> Meas. Sci. Techn., 2013 March; 24(4)\u00a0pdf<\/a><\/p>\n

T O\u2019Sullivan, A Leproux, J Chen, S Bahri, A Matlock, Darren Roblyer ,CE. McLaren, W Chen, A Cerussi, M Su, BJ Tromberg, \u201cOptical imaging correlates with magnetic resonance imaging breast density and reveals composition changes during neoadjuvant chemotherapy,\u201d<\/em> Breast Cancer Research, 2013 Feb; 15<\/p>\n

2012<\/strong><\/p>\n

Darren Roblyer*, Ueda S*, Cerussi A, Durkin A, Leproux A, Santoro Y, Xu S, O\u2019Sullivan T, Hsiang D, Mehta R, Butler J, Tromberg BJ. \u201cBaseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,\u201d<\/em>\u00a0Cancer Research. , 2012 July; *shared first authorship\u00a0pdf<\/a><\/p>\n

A. Cerussi ,R. Warren,\u00a0<\/span>B. Hill,\u00a0<\/span>Darren Roblyer, A. Leproux,\u00a0<\/span>A.F. Durkin,\u00a0<\/span>T.D. O\u2019Sullivan,\u00a0<\/span>S. Keene,\u00a0<\/span>H.Haghany,\u00a0<\/span>T.Quang,\u00a0<\/span>W.M. Mantulin, and\u00a0<\/span>B.J. Tromberg, \u201cTissue phantoms in multicenter clinical trials for diffuse optical technologies,\u201d<\/em>, Biomedical Optics Express, 2012 April; 3(5)<\/p>\n

2011<\/strong><\/p>\n

Darren Roblyer*, S. Ueda*, A. Cerussi, Tanamai W., A. Durkin, R. Metha, D. Hsiang, J. Butler, C.E. McLaren, W. Chen, B. Tromberg. \u201cIn Vivo Optical Imaging of Breast Cancer Oxyhemoglobin Flare Correlates with Neoadjuvant Chemotherapy Response One Day after Starting Treatment,\u201d<\/em>\u00a0Proceedings of the National Academy of Sciences, United States of America. 108 (35). (2011 Aug) *shared first authorship\u00a0pdf<\/a><\/p>\n

T. Muldoon,\u00a0Darren Roblyer, M.D. Williams, V.M. Stepanek, R. Richards-Kortum, A.M. Gillenwater. \u201cNonivasive imaging of oral neoplasia with a high-resolution fiber-optics microendoscope,\u201d<\/em>\u00a0Head and Neck. (16). (2011 Mar)\u00a0pdf<\/a><\/p>\n

2010<\/strong><\/p>\n

Darren Roblyer, C. Kurachi , V. Stepanek , R. Schwarz, M. Williams , A. El-Naggar , J. Jack Lee , A. Gillenwater, R. Richards-Kortum. \u201cComparison of Multispectral Widefield Optical Imaging Modalities to Maximize Image Contrast for Objective Discrimination of Oral Neoplasia,\u201d<\/em>\u00a0Journal of Biomedical Optics. 15 (6). (2010 Nov-Dec)\u00a0pdf<\/a><\/p>\n

T. Muldoon , N.Thekkek , Darren Roblyer, D. Maru , N. Harpaz , J. Potack , S. Anandasabapathy , R. Richards-Kortum, \u201cEvaluation of Quantitative Image Analysis Criteria for the High-Resolution Micro-Endoscopic Detection of Neoplasia in Barrett’s Esophagus,\u201d<\/em> Journal of Biomedical Optics, 2010 Mar-Apr;15(2).<\/p>\n

Mohammed Rahman, N. Ingole, Darren Roblyer, V. Stepanek, R. Richards-Kortum, A.Gillenwater, S. Shastri, and P. Chaturvedi, “Evaluation of A Low-Cost, Portable Imaging System for Early Detection of Oral Cancer,”<\/em> Head and Neck Oncology, 2010 Feb;2(10).<\/span><\/p>\n

2009<\/strong><\/p>\n

Darren Roblyer , C. Kurachi , V. Stepanek , M. Williams , A. El-Naggar , J. Jack Lee , A. Gillenwater, R. Richards-Kortum. \u201cObjective Detection and Delineation of Oral Neoplasia Using Autofluorescence Imaging,\u201d<\/em>\u00a0Journal of Cancer Prevention Research. 2 (5): 423-31. (2009 May)\u00a0pdf<\/a><\/p>\n

2008<\/strong><\/p>\n

Darren Roblyer, Sokolov KV, El-Naggar A, Williams M , Kurachi C , Gillenwater A, Rebecca Richards-Kortum. \u201cA Multispectral Optical Imaging Device for In Vivo Detection of Oral Neoplasia,\u201d<\/em> Journal of Biomedical Optics. 13 (2). (2008 Mar-Apr)\u00a0pdf<\/a><\/p>\n

Javier, David*; Nitin, Nitin*; Darren Roblyer; Richards-Kortum, Rebecca, \u201cMetal based nanorods as molecular specific contras agents for reflectance imaging in 3D tissues,\u201d<\/em> Nanophotonics. 2008 April;2<\/p>\n

2007<\/strong><\/p>\n

Darren Roblyer, Park SY, Richards-Kortum R, Adewole I, Follen M, \u201cObjective Screening for Cervical Cancer in Developing Nations: Lessons from Nigeria,\u201d<\/em> Gynecologic Oncology. 2007 Oct;107(1 Suppl 1)<\/p>\n

Nitin Nitin , David Javier , Darren Roblyer, Rebecca Richards-Kortum, \u201cWidefield and High Resolution Reflectance Imaging of Gold and Silver Nanospheres,\u201d<\/em> Journal of Biomedical Optics. 2007 Sep-Oct;12(5)<\/p>\n

Book Chapters:<\/h4>\n

Y. Zhao, A. Pilvar, M. C. Pierce, and Darren Roblyer, \u201cShort-Wave Infrared Meso-Patterned Imaging for Quantitative and Label-Free Tissue Characterization,\u201d<\/em> in Short-Wavelength Infrared Windows for Biomedical Applications, L. A. Sordillo and P. P. Sordillo, Eds., SPIE Press, Bellingham, Washington, pp. 141\u2013159 (2022) DOI: 10.1117\/3.2604326.ch4.<\/p>\n

J. Ferruzzi, Y. Zhang, Darren Roblyer and M. H. Zaman, \u201cChapter: Multi-scale Mechanics of Collagen Networks: Biomechanical Basis of Matrix Remodeling in Cancer\u201d,<\/em> Multi-scale Extracellular Matrix Mechanics and Mechanobiology, Yanhang Zhang (Editor), Springer Nature, 2019<\/p>\n

M Wall, T Heaster, K Tilbury, WJ Choi, Darren Roblyer, R Wang, M Skala, J.T.C. Liu, \u201cChapter 5: Metabolic Imaging Approaches: Optical Imaging,\u201d<\/em> Imaging and Metabolism, Jason S. Lewis and Kayvan R. Keshari (Editors), Springer Nature, 2018<\/p>\n

Darren Roblyer, R. Schwarz, R. Richards-Kortum, \u201cFluorescence Spectroscopy,\u201d<\/em>\u00a0Handbook of Biomedical Optics, D. Boas, C. Pitris, N. Ramanujam (Editors), Taylor and Francis, 2011.<\/p>\n

Darren Roblyer, A Cerussi, B.J.Tromberg, \u201cDiffuse Optical Spectroscopic Imaging of Breast Cancer,\u201d<\/em> McGraw-Hill Series in Biophotonics,\u00a0James Tunnel (Editor), McGraw-Hill, 2011.<\/p>\n","protected":false},"excerpt":{"rendered":"

Peer Reviewed Publications: 2026 Aarohi Mahesh Mehendale, Darren Roblyer NIH funding in the biophotonics community, Biophotonics Discovery 3(2), 020601 (5 Jun 2026) link Diana Suciu, Thao Pham, Lina Lin Wei, Isaac Hoekstra, Pranav Yadati, Vipul C. Chitalia, Darren Roblyer, Frequency-domain broadband near-infrared spectroscopy for noninvasive monitoring of fluid volume status during hemodialysis. Biophoton. Discovery 3(1) […]<\/p>\n","protected":false},"author":6429,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/botlab\/wp-json\/wp\/v2\/pages\/32"}],"collection":[{"href":"https:\/\/www.bu.edu\/botlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/botlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/botlab\/wp-json\/wp\/v2\/users\/6429"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/botlab\/wp-json\/wp\/v2\/comments?post=32"}],"version-history":[{"count":50,"href":"https:\/\/www.bu.edu\/botlab\/wp-json\/wp\/v2\/pages\/32\/revisions"}],"predecessor-version":[{"id":1200,"href":"https:\/\/www.bu.edu\/botlab\/wp-json\/wp\/v2\/pages\/32\/revisions\/1200"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/botlab\/wp-json\/wp\/v2\/media?parent=32"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}