{"id":85,"date":"2011-01-07T15:09:20","date_gmt":"2011-01-07T20:09:20","guid":{"rendered":"https:\/\/www.bu.edu\/bmo\/?page_id=85"},"modified":"2025-11-20T17:39:56","modified_gmt":"2025-11-20T22:39:56","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/bmo\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<div>\n<p><strong>2025<\/strong><\/p>\n<ul>\n<li><span class=\"authors-list-item \">Ayman A Abdelhakeem,<span class=\"comma\">\u00a0<\/span><\/span><span class=\"authors-list-item \">Shuaibin Chang<sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><\/sup><span class=\"comma\">, <\/span><\/span><span class=\"authors-list-item \">Anna Novoseltseva<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Mackenzie Hyman<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Ann C Mckee<sup class=\"affiliation-links\">\u00a0<\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Irving J Bigio<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">David A Boas<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \">Bertrand R Huber<span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><span class=\"authors-list-item \">Hui Wang, <a href=\"\/bmo\/files\/2025\/11\/Abdelhakeem_Ayman_Lipofuscin_Neurophotonics2025.pdf\">Quantitative analysis of lipofuscin in neurodegenerative diseases using serial sectioning two-photon microscopy and fluorescence lifetime imaging microscopy<\/a>, Neurophotonics,<\/span><\/span><span class=\"period\">\u00a0<\/span><span class=\"cit\">2025 Jul;12(3):035007.<\/span><\/li>\n<li>Aslan, M., Gray, A.J., Packard, L. <i>et al.<\/i> <a href=\"\/bmo\/files\/2025\/11\/Aslan_et_al-2025-Scientific_Reports.pdf\">Impact of uniform illumination in widefield microscopy and mesoscopy.<\/a> <i>Sci Rep<\/i> <b>15<\/b>, 25400 (2025).\n<div class=\"PAHArticleCol\" id=\"mainArticle\">\n<div id=\"divArticleContent\">\n<div class=\"panel panel-default ArticleContentPanel\">\n<div class=\"panel-body\">\n<div class=\"row ArticleContentRow\" id=\"articleCitation\">\n<div class=\"panel panel-default ArticleContentPanel\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li>Alexander J Gray, Rhiannon E Robinson, Samer A Berghol, Douglas L Rosene, Tara L Moore, and Irving J Bigio, <a href=\"\/bmo\/files\/2025\/11\/Gray_qBRM-cortical-injury_Neurophotonics2025-1.pdf\">Birefringence microscopy enables rapid, label-free quantification of myelin debris following induced cortical injury<\/a>, Neurophotonics, 2025 Dec;12(4) 045006.<\/li>\n<li>Samuel C Halvorsen, Anastasia Gkousioudi, Raymond Nicks, Victor E Alvarez, Irving J Bigio, Joseph Zaia, Thor D Stein, and Yanhang Zhang, <a href=\"\/bmo\/files\/2025\/11\/Halvorsen_biomechanics_Frontiers-Bioen_2-1597917_2025.pdf\">Cerebrovascular remodeling in aging and neorodegenerative disease progression<\/a>, Front. Bioeng. Biotechnol. 13:1597917.<\/li>\n<li>Novoseltseva A, Kureli G, Chang S,et al. <a href=\"\/bmo\/files\/2025\/11\/Novoseltseva__Imaging-myelin-degradation_AlzheimersDementia-2025.pdf\">Imaging myelin degradation in ex vivo prefrontal cortex tissue blocks in Alzheimer\u2019s disease and chronic traumatic encephalopathy.<\/a> Alzheimer\u2019s Dement. 2025;21:e70582.<\/li>\n<li>Anna Novoseltseva, Arjun Chandra, Alexander J Gray, Shuying Li, Mikayla Bradsby, and Irving J Bigio, <a href=\"\/bmo\/files\/2025\/11\/Novoseltseva_DL-paper_Neurophot-2025.pdf\">Accelerating myelin defect detection in neurodegenerative disorders: a human-in-the-loop deep learning approach with birefringence microscopy<\/a>, Neurophotonics, 2025 Dec; 12(4) 045007.<\/li>\n<li>Cheng et al. <a href=\"\/bmo\/files\/2025\/11\/Tian_Li_digital-staining_Light-Sci-Appl_2025.pdf\">Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography<\/a>, Light: Science &amp; Applications ( 2025) 14:57.<\/li>\n<\/ul>\n<p><strong>2024<\/strong><\/p>\n<ul>\n<li>Nathan Blanke, Alexander J. Gray, Rhiannon E. Robinson, Anna Novoseltseva, Douglas L. Rosene, Irving J. Bigio, <a href=\"\/bmo\/files\/2025\/11\/Blanke_Gray_Imaging-Neurosci_2024.pdf\">Practical considerations for birefringence microscopy of myelin structure: Microscope design and tissue processing for effective imaging<\/a>, Imaging Neuroscience, Volume 2, 2024.<\/li>\n<li>Danielle Manolakos, Genevieve Patrick, John K. Geisse, Harold Rabinovitz, Kendall Buchanan, Preston Hoang, Eladio Rodriguez-Diaz, Irving J. Bigio, Armand B. Cognetta, <a href=\"\/bmo\/files\/2024\/02\/Dermasensor-paper-2.pdf\">Use of an elastic-scattering spectroscopy and artificial intelligence device in the assessment of lesions suggestive of skin cancer: A comparative effectiveness study,\u00a0<\/a> JAAD International, Volume 14, 52-58 (2024).<\/li>\n<\/ul>\n<p><strong>2023<\/strong><\/p>\n<ul>\n<li>\n<div class=\"citation-text\">Blanke N, Chang S, Novoseltseva A, Wang H, Boas DA, Bigio IJ. <a href=\"\/bmo\/files\/2024\/02\/BlankeChang_BOE-2023.pdf\">Multiscale label-free imaging of myelin in human brain tissue with polarization-sensitive optical coherence tomography and birefringence microscopy<\/a>. Biomed Opt Express. 2023 Oct 24;14(11):5946-5964.<\/div>\n<\/li>\n<\/ul>\n<p><strong>2022<\/strong><\/p>\n<ul>\n<li>Eladio Rodriguez-Diaz, Lisa I. Jepeal, Gy\u00f6rgy Baffy, Wai-Kit Lo, Hiroshi Mashimo MD, Ousama A&#8217;amar, Irving J. Bigio, Satish K. Singh, <a href=\"\/bmo\/files\/2023\/10\/Eladio_2021-Digestive_Diseases-Sci.pdf\">Artifical Intelligence-Based Assessment of Colorectal Polyp Histology by Elastic-Scattering Spectroscopy<\/a>, Digestive Diseases and Sciences, <span class=\"cit\">2022 67(2):613-621 (2022)<\/span><\/li>\n<\/ul>\n<p><strong>2021<\/strong><\/p>\n<ul>\n<li>Nathan Blanke, Veronica Go, Douglas L. Rosene, and Irving J. Bigio<a href=\"\/bmo\/files\/2023\/10\/Blanke_qBRM_Neurophotonics_March2021.pdf\">&#8220;Quantitative birefringence microscopy for imaging the structural integrity of CNS myelin following circumscribed cortical injury in the rhesus monkey&#8221;<\/a>, Neurophotonics, Vol 8(1) 015010-1:15 (2021).<\/li>\n<li>Eladio Rodriguez-Diaz, Samer Kaanan, Christopher Vanley, Tauseef Quereshi, and Irving J. Bigio, <a href=\"\/bmo\/files\/2023\/10\/Eladio_Concur-lung-paper_JBIO-2021.pdf\">Toward optical spectroscopy-guided lung biopsy: Demonstration of tissue-type classification&#8221;<\/a>, Journal of Biophotonics, 14(10) e202100132 (2021).<\/li>\n<li>Syeda Tabassum, Anup Tank, Fay Wang, Kavon Karrobi, Cameron Vergato, Irving J. Bigio, David J. Waxman, and Darren Roblyer, <a href=\"\/bmo\/files\/2023\/10\/Syeda_scattering-apoptosis_Neoplasia-2021.pdf\">&#8220;Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer&#8221;<\/a>, Neoplasia, 23(3):294-303. (2021)<\/li>\n<\/ul>\n<p><strong>2019<\/strong><a href=\"\/bmo\/files\/2023\/10\/Belghasem_et_al-2019-Scientific_Reports.pdf\"><\/a><\/p>\n<ul>\n<li>Mostafa E. Belghasem, Ousama A&#8217;amar, Daniel Roth, Joshua Walker, Nkiruka Arinze, Sean M. Richards, Jean M. Francis, David J. Salant, Vipul C. Chitalia, and Irving J. Bigio, <a href=\"\/bmo\/files\/2023\/10\/Belghasem_et_al-2019-Scientific_Reports.pdf\">&#8220;Towards minimally-invasive, quantitative assessment of chronic kidney diseas using optical spectroscopy&#8221;<\/a>, Nature Scientific Reports, 9:7168 (2019)<\/li>\n<li>Eladio Rodriguez-Diaz, Danielle Manolakos, Holly Christman, Michael A. Bonning, John K. Geisse, Ousama M. A&#8217;amar, David J. Leffell, and Irving J. Bigio, <a href=\"\/bmo\/files\/2023\/10\/Eladio_et_al-2019-Photochemistry_and_Photobiology.pdf\">&#8220;Optical Spectroscopy as a Method for Skin Cancer Risk Assessment&#8221;<\/a>, Photochemistry and Photobiology, 2019, 95: 1441-1445.<\/li>\n<li>Uraib Sharaha, Eladio Rodriguez-Diaz, Orli Sagi, Klaris Reisenberg, Ahmad Salman, Irving J. Bigio, and Mahmoud Huleihel, <a href=\"\/bmo\/files\/2023\/10\/Sharaha_et_al-2019-Journal_of_Biophotonics.pdf\">&#8220;Fast and reliable determination of Escherichia coli susceptibility to antibiotics: Infrared microscopy in tandem with machine learning algorithms&#8221;<\/a>, J. Biophotonics. 2019 12(7):e201800478.<\/li>\n<\/ul>\n<p><strong>2018<\/strong><\/p>\n<ul>\n<li>Ying Zhu, Tom Fearn, D. Wayne Chicken, Martin R. Austwick, Santosh K. Somasundaram, Charles A. Mosse, Benjamin Clark, Irving J. Bigio, Mohammed R.S. Keshtgar, and Stephen G. Bown, <a href=\"\/bmo\/files\/2023\/10\/Ying-Zhu_ESS-classification-of-nodes_JBO-2018.pdf\">&#8220;Elastic scattering spectroscopy for early detection of breast cancer: partially supervised Baysean image classification of scanned sentinal lymph nodes&#8221;<\/a>, J. Biomedical Optics 23(8), 085004 (2018).<\/li>\n<\/ul>\n<p><strong>2017<\/strong><\/p>\n<ul>\n<li>Gregory A. Grillone, MD, FACS, Zimmern Wang, MD, Gintas P. Krisciunas, MPH, MA, Angela C. Tsai, MD, Vishnu R. Kannabiran, MD, Robert W. Pistey, MD, Qing Zhao, MD, PhD; Eladio Rodriguez-Diaz, PhD, Ousama M. A\u2019Amar, PhD, Irving J. Bigio, PhD,<a href=\"\/bmo\/files\/2023\/10\/Grillone_et_al-2017-The_Laryngoscope.pdf\">&#8220;The Color of Cancer: Margin Guidance for Oral Cancer Resection Using Elastic Scattering Spectroscopy&#8221;<\/a>, Laryngoscope, 127: S1-S9, 2017.<\/li>\n<li>Juliane Nguyen, Shaolie S. Hossain, Johann R.N. Cooke, Jason A. Ellis, Michael B. Deci, Charles W. Emala, Jeffrey N. Bruce, Irving J. Bigio, Robert M Straubinger, Shaliendra Joshi, <a href=\"\/bmo\/files\/2023\/10\/Joshi_FLow-arrest-micelles_J-neuro-onc2017.pdf\">&#8220;Flow arrect intra-areterial delivery of small TAT-decorated and neutral micelles to gliomas&#8221;,<\/a> J Neurooncol. (2017) 133(1):77-85.<\/li>\n<li>Ahmad Salman, Uraib Sharaha, Eladio Rodriguez-Diaz, Elad Shufan, Klaris Riesenberg, Irving J. Bigio, and Mahmoud Huleihel, <a href=\"\/bmo\/files\/2023\/10\/Salman_antibiot-resist_Analyst-2017.pdf\">Detection of antibiotic resistant Escherichia Coli bacteria using infrared microscopy and advanced multivariate analysis<\/a>, Analyst, 2017, 142, 2136-2144.<\/li>\n<li>Uraib Sharaha, Eladio Rodriguez-Diaz, Klaris Riesenberg, Irving J. Bigio, Mahmoud Huleihel, and Ahmad Salman, <a href=\"\/bmo\/files\/2023\/10\/Salman_Analyt-Chem_2017.pdf\">&#8220;Using Infrared Spectroscopy and Multivariate Analysis to Detect Antibiotics&#8217; Resistant Escherichia coli Bacteria&#8221;<\/a>, Analytical Chemistry, 2017, 89, 8782-8790.<\/li>\n<\/ul>\n<p style=\"font-weight: bold;\">2016<\/p>\n<ul>\n<li>Joseph Angelo, Christina R. Vargas, Bernard T. Lee, Irving J. Bigio, Sylvain Gioux,\u00a0<a href=\"\/bmo\/files\/2023\/10\/Angelo_LUT-paper_JBO_2016.pdf\">\u201cUltrafast optical property map generation using lookup tables,\u201d<\/a> Opt. 21(11), 110501 (2016),<\/li>\n<li><a href=\"https:\/\/www.osapublishing.org\/abstract.cfm?uri=BRAIN-2016-JW3A.27\">Badreddine, Ali H., Jordan, T., and Bigio, I. J., &#8220;Real-time imaging of action potentials in nerves using changes in birefringence,&#8221;<\/a> , Biomed. Opt. Express<em>\u00a07, 1966\u20131973 (2016).<\/em><a href=\"\/bmo\/files\/2023\/10\/Angelo_LUT-paper_JBO_2016.pdf\"><\/a><\/li>\n<li>Jason A. Ellis, Johann Cooke, Rajinder P. Singh-Moon, Mei Wang, Mei Wang, Jeffrey N. Bruce, Charles W. Emala, Irving J. Bigio, and Shaliendra Joshi, <a href=\"\/bmo\/files\/2023\/10\/Joshi_IA-MTX-safety_J-Neurooncol2016.pdf\">&#8220;Safety, feasibility, and optimization of intra-arterial mitoxantrone delivery to gliomas&#8221;<\/a>, J Neurooncol (2016) 130(3):449-454.<\/li>\n<li>Juliane Nguyen, Johann R.N. Cooke, Jason A. Ellis, Michael Deci, Charles W. Emala, Jeffrey N. Bruce, Irving J. Bigio, Robert M. Straubinger, Shaliendra Joshi, <a href=\"\/bmo\/files\/2023\/10\/Joshi_Cation-lipid-micel_Neuroonc-2016.pdf\">&#8220;Cationizable lipid micelles as vehicles for intraarterial glioma treatment&#8221;<\/a>, J Neurooncol. (2016) 128:21-28.<\/li>\n<\/ul>\n<p style=\"font-weight: bold;\">2015<a href=\"\/bmo\/files\/2023\/10\/Belghasem_et_al-2019-Scientific_Reports.pdf\"><\/a><\/p>\n<ul>\n<li><a href=\"https:\/\/www.osapublishing.org\/boe\/abstract.cfm?uri=boe-6-10-4165\">Badreddine, Ali H., Schoener, K.\u00a0J., and Bigio, I. J., &#8220;Elucidating the temporal dynamics of optical birefringence changes in crustacean nerves.,&#8221;<\/a> Biomed. Opt. Express<em> 6, 4165\u201378 (2015).<\/em><\/li>\n<\/ul>\n<p style=\"font-weight: bold;\">2014<\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2014\/09\/Raj_SFDI-drug-delivery_JBO-Sept2014.pdf\">Singh-Moon, Rajinder P., Roblyer, Darren M., Bigio, Irving J., Joshi, Shailendra, &#8220;Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging,&#8221;<\/a> Journla of Biomedical Optics 19(9), 096003 (September 2014).<\/li>\n<li><a href=\"\/bmo\/files\/2014\/07\/Calabro_JBO-online-published_July2014.pdf\"> Calabro, Katherine W.,<br \/>\nBigio, Irving J., &#8220;Influence of the phase function in generalized diffuse reflectance models: review of current formalisms and novel observations,&#8221;<\/a> Journal of Biomedical Optics 19(7), 075005 (July 2014).<\/li>\n<\/ul>\n<p style=\"font-weight: bold;\">2013<\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2014\/01\/Laser-in-Medical-science-Prostate.pdf\"> A\u2019Amar, O. M., Liou, L., Rodriguez-Diaz, E., De las Morenas, A, Bigio, I. J. , &#8220;Comparison of elastic scattering spectroscopy with histology in ex vivo prostate glands: potential application for opticallyguided biopsy and directed treatment,&#8221; <\/a> Lasers Med Sci (2013) 28:1323\u20131329.<\/li>\n<li><a href=\"\/bmo\/files\/2014\/01\/Throid-IEEE-Biomedical-Transactions.pdf\"> J. Rosen, H. Suh, N. Giordano, O. A\u2019amar, E. Rodriguez-Diaz, I. Bigio, and S. Lee , &#8220;Preoperative Discrimination of Benign from Malignant Disease in Thyroid Nodules with Indeterminate Cytology Using Elastic Light-Scattering Spectroscopy,&#8221; <\/a> IEEE transactions on bio-medical engineering, Jun. 2013.<\/li>\n<\/ul>\n<p style=\"font-weight: bold;\">2012<\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2012\/09\/Ergin_Joshi_JBO-MAY2012.pdf\">Ergin, A., Wang, M., Zhang, J., Bigio, I.J., &amp; Joshi, S., &#8220;Noninvasive <em>in vivo<\/em> optical assessment of blood brain barrier permeability and brain tissue drug deposition in rabbits,&#8221; <\/a> Journal of Biomedical Optics 17(5), May 2012.<\/li>\n<\/ul>\n<p style=\"font-weight: bold;\">2011<\/p>\n<ul>\n<li><a href=\"..\/files\/2011\/11\/Austwick-et-al-JIOHS-Vol4-No2-2011-97-11.pdf\">Austwick, M.R., Woodhams, J.H., Chalau, V., Mosse, C. a, Eliot, C., Lovat, L., Macrobert, A.J., Bigio, I.J. &amp; Bown, S.G., \u201cOptical Measurement of Photosensitizer Concentration in Vivo,\u201d<\/a> Journal of Innovative Optical Health Sciences, vol. 04, 2011, p. 97.<\/li>\n<li><a href=\"..\/files\/2011\/11\/Mulvey_Apoptosis-JBO-Part-2.pdf\">Mulvey, C.S., Zhang, K., Bobby Liu, W.-H., Waxman, D.J. &amp; Bigio, I.J., \u201cWavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, Part 2: early spectral changes during apoptosis are linked to apoptotic volume decrease.,\u201d<\/a> Journal of biomedical optics, vol. 16, Nov. 2011, p. 117002.<\/li>\n<li><a href=\"..\/files\/2011\/11\/Mulvey_Apoptosis-JBO-Part-1.pdf\">Mulvey, C.S., Zhang, K., Liu, W.-H.B., Waxman, D.J. &amp; Bigio, I.J., \u201cWavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, Part 1: early and late spectral changes are indicative of the presence of apoptosis in cell cultures.,\u201d<\/a> Journal of biomedical optics, vol. 16, Nov. 2011, p. 117001.<\/li>\n<li><a href=\"..\/files\/2011\/11\/Eladio-JBO-SVMER.pdf\">Rodriguez-Diaz, E., Castanon, D. a, Singh, S.K. &amp; Bigio, I.J., \u201cSpectral classifier design with ensemble classifiers and misclassification-rejection: application to elastic-scattering spectroscopy for detection of colonic neoplasia.,\u201d<\/a> Journal of biomedical optics, vol. 16, Jun. 2011, p. 067009.<\/li>\n<li><a href=\"..\/files\/2011\/11\/Rosen_Annals-Surg-Onc_ESS-thyroid_5_2011.pdf\">Suh, H., A\u2019amar, O., Rodriguez-Diaz, E., Lee, S., Bigio, I. &amp; Rosen, J.E., \u201cElastic light-scattering spectroscopy for discrimination of benign from malignant disease in thyroid nodules.,\u201d<\/a> Annals of surgical oncology, vol. 18, May. 2011, pp. 1300-5.<\/li>\n<li><a href=\"..\/files\/2011\/11\/Eladio-tools-paper.pdf\">Rodriguez-Diaz, E., Bigio, I.J. &amp; Singh, S.K., \u201cIntegrated Optical Tools for Minimally Invasive Diagnosis and Treatment At Gastrointestinal Endoscopy.,\u201d<\/a> Robotics and computer-integrated manufacturing, vol. 27, Apr. 2011, pp. 249-256.<\/li>\n<li><a href=\"\/bmo\/files\/2011\/10\/NEON_IVICG_Oct2011_fulltext.pdf\">A. Ergin, M. Wang, J.Y. Zhang, J.N. Bruce, R. L. Fine, I. J. Bigio, S. Joshi, &#8220;The feasibility of real-time in vivo optical detection of blood-brain barrier disruption with indocyanine green,&#8221;<\/a> Journal of Neuro-Oncology (2011)<\/li>\n<li><a href=\"\/bmo\/files\/2011\/10\/Neurosurgery_Sept2011.pdf\">S. Joshi, R. Reif, M. Wang, J. Zhang, A. Ergin, J. N. Bruce, R. L. Fine, I. J. Bigio, &#8220;Intra-arterial Mitoxantrone Delivery in Rabbits: An Optical Pharmocokinetic Study,&#8221; <\/a>Neurosurgery 69: 706-712 (2011)<\/li>\n<li><a href=\"\/bmo\/files\/2011\/02\/Gender-Variations-in-the-Optical-Properties-of-Skin-in-Murine-Animal-Models.pdf\">K. Calabro, A. Curtis, J.-R. Galarneau, T. Krucker, I. J. Bigio, &#8220;Gender Variation in the optical properties of skin in murine animal models,&#8221;<\/a> Journal of Biomedical Optics\u00a016 (1), 011008 (2011)<\/li>\n<\/ul>\n<p style=\"font-weight: bold;\">2010<\/p>\n<div id=\"_mcePaste\">\n<ul>\n<li><a href=\"..\/files\/2011\/11\/Keshtgar-BJS-paper_scanning-nodes.pdf\">Keshtgar, M.R.S., Chicken, D.W., Austwick, M.R., Somasundaram, S.K., Mosse, C. a, Zhu, Y., Bigio, I.J. &amp; Bown, S.G., \u201cOptical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer.,\u201d<\/a> The British journal of surgery, vol. 97, Aug. 2010, pp. 1232-9.<\/li>\n<li><a href=\"..\/files\/2011\/11\/Austwick-scanning-node_JBO-2010.pdf\">Austwick, M.R., Clark, B., Mosse, C. a, Johnson, K., Chicken, D.W., Somasundaram, S.K., Calabro, K.W., Zhu, Y., Falzon, M., Kocjan, G., Fearn, T., Bown, S.G., Bigio, I.J. &amp; Keshtgar, M.R.S., \u201cScanning elastic scattering spectroscopy detects metastatic breast cancer in sentinel lymph nodes.,\u201d<\/a> Journal of biomedical optics, vol. 15, 2010, p. 047001.<\/li>\n<li><a href=\"\/bmo\/files\/2011\/03\/Inconsistent-blood-brain-barrier-disruption.pdf\">S. Joshi, A. Ergin, M. Wang, R. Reif, J. Zhang, J.N. Bruce, I. J. Bigio, &#8220;Inconsistent blood brain barrier disruption by intraarterial mannitol in rabbits: implications for chemotherapy,&#8221; <\/a>Journal of Neuro-Oncology (2010)<\/li>\n<li><a href=\"\/bmo\/files\/2011\/02\/Temporal-Variations-of-Skin-Pigmentation-in-c57Bl6-Mice.pdf\">A. Curtis, K. Calabro, J.-R. Galarneau, I. J. Bigio,\u00a0T. Krucker, &#8220;Temporal Variations of Skin Pigmentation\u00a0in C57Bl\/6 Mice Affect Optical Bioluminescence\u00a0Quantitation,&#8221;<\/a> Molecular Imaging and Biology (2010)<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p><strong>2009<\/strong><\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2011\/01\/Ying_EROS_JBO.pdf\">Y. Zhu, T. Fearn, G. Mackenzie, B. Clark, J. M. Dunn, I. S. Bigio, S. G. Brown, L. B. Lovat, &#8220;Elastic scattering spectroscopy for detection of cancer risk in Barrett\u2019s esophagus: experimental and clinical validation of error removal by orthogonal subtraction for increasing accuracy,&#8221;<\/a> Journal of Biomedical Optics\u00a014\u00a0(4), 044022 (2009)<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/Mulvey_JBO-2_paper.pdf\">Christine S. Mulvey, Carly A. Sherwood, Irving J. Bigio, &#8220;Wavelength-dependent backscattering measurements for quantitative real-time monitoring of apoptosis in living cells,&#8221;<\/a>Journal of Biomedical Optics 14 (6), 064013 (2009)<\/li>\n<\/ul>\n<p><strong>2008<\/strong><\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2011\/01\/Georgescu-2008.pdf\">R. Georgescu, D. Khismatullin, R. G. Holt, J. L. Castagner, O. A&#8217;Amar and I. J. Bigio, &#8220;Design of a system to measure light scattering from individual cells excited by an acoustic wave,&#8221;<\/a> Opt. Expr.16(6), 3496-3503 (2008)<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/Reif-JBO-010502-2008.pdf\">R. Reif, M. S. Amorosino, K. W. Calabro, O. A&#8217;Amar, S. K. Singh and I. J. Bigio, &#8220;Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures,&#8221;<\/a> J. Biomed. Opt.\u00a013(1), 010502 (2008)<\/li>\n<\/ul>\n<p><strong>2007<\/strong><\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2011\/01\/CLASS-PNAS-paper-10_07.pdf\">I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, and L. T. Perelman, &#8220;Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,&#8221;<\/a> PNAS\u00a0104\u00a0(44), 17255-17260 (2007)<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/Fang-AO_April_2006.pdf\">H. Fang, L. Qiu, E. Vitkin, M. M. Zaman, C. Andersson, S. Salahuddin, L. M. Kimerer, P. B. Cipolloni, M. D. Modell, B. S. Turner, S. E. Keates, I. Bigio, I. Itzkan, S. D. Freedman, R. Bansil, E. B. Hanlon, and L. T. Perelman, &#8220;Confocal light absorption and scattering spectroscopic microscopy,&#8221;<\/a> Applied Optics\u00a046(10), 1760-1769 (2007)<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/Mulvey-2007.pdf\">C. S. Mulvey, A. L. Curtis, S. K. Singh and I. J. Bigio, &#8220;Elastic scattering spectroscopy as a diagnostic tool for apoptosis in cell cultures,&#8221;<\/a> IEEE J. of Sel. Top. in Quant. Elect.\u00a013(6), 1663-1670 (2007)<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/Reif-AO-2007.pdf\">R. Reif, O. A&#8217;Amar and I. J. Bigio, &#8220;Analytical model of light reflectance for the extraction of the optical properties in small volumes of turbid media,&#8221;<\/a> Applied Optics\u00a046(29), 7317-7328 (2007)<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/Reif-JBO-034036-2007.pdf\">R. Reif, M. Wang, S. Joshi, O. A&#8217;Amar and I. J. Bigio, &#8220;Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue,&#8221;<\/a> J. Biomed. Opt.\u00a012(3), 034036 (2007)<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/Nephelometer_paper2_AO.pdf\">JL Castagner and IJ Bigio, &#8220;Particle sizing with a fast polar nephelometer,&#8221;<\/a>Applied Optics\u00a046:\u00a0No. 4, 527-532 (2007)<\/li>\n<\/ul>\n<p><strong>2006<\/strong><\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2011\/01\/J_L_nephelometer_AO_04_06.pdf\">Jean-Luc Castagner and Irving J. Bigio, &#8220;Polar nephelometer based on a rotational\u00a0confocal imaging setup&#8221;<\/a> Applied Optics\u00a045:\u00a0No. 10, 2232-2239 (2006)<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/LovatGut2006ESS.pdf\">L B Lovat, K Johnson, G D Mackenzie, B R Clark, M R Novelli, S Davies, M O\u2019Donovan, C Selvasekar, S M Thorpe, D Pickard, R Fitzgerald, T Fearn, J Bigio and SG Bown, &#8220;Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett\u2019s oesophagus&#8221;<\/a> Gut\u00a02006;55:1078-1083 (2006).<\/li>\n<li><a href=\"..\/files\/2011\/11\/Hopper_Oral-Cancer_2006.pdf\">Sharwani, a, Jerjes, W., Salih, V., Swinson, B., Bigio, I.J., El-Maaytah, M. &amp; Hopper, C., \u201cAssessment of oral premalignancy using elastic scattering spectroscopy.,\u201d<\/a> Oral oncology, vol. 42, Apr. 2006, pp. 343-9.<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/Dahr-GI-Endoscopy-colon-paper.pdf\">Anjan Dhar, DM, MRCP, Kristie S. Johnson, DPhil, Marco R. Novelli, PhD, FRCPath, Stephen G. Bown, MD, FRCP, Irving J. Bigio, PhD, Laurence B. Lovat, PhD, FRCP, Stuart L. Bloom, DM, FRCPPDF\u00a0\u00a0 &#8220;Elastic scattering spectroscopy for the diagnosis of colonic lesions:\u00a0 initial results of a novel optical biopsy technique&#8221;<\/a>GASTROINTESTINAL ENDOSCOPY,\u00a0Vol. 63 No. 2, 2579-261 (2006).<\/li>\n<\/ul>\n<p><strong>2004<\/strong><\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2011\/01\/Bigio-Bown-1.pdf\">IJ Bigio and SG Bown, &#8220;Spectroscopic sensing of cancer and cancer chemotherapy, current status of translational research,&#8221;<\/a> Cancer Biology and Therapy 3,\u00a0No. 3, 259-267 (2004).<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/Aamar-Ley-Bigio-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">O A&#8217;Amar, RD Ley, IJ Bigio, &#8220;Comparison between UV-visible and NIR elastic-scattering spectroscopy of chemically induced melanomas in an animal model,&#8221; <\/a>Journal of Biomedical optics\u00a09(6): 1320-1326 (2004).<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/Johnson-Chicken-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">KS Johnson, DW Chicken, DCO Pickard, AC Lee, G Briggs, M Falzon, IJ Bigio, MR Keshtgar, SG Bown, &#8220;Elastic scattering spectroscopy for intraoperative determination of sentinel lymph node status in the breast,&#8221; <\/a>Journal of Biomedical optics\u00a09(6): 1122-1128 (2004).O A&#8217;Amar, MS Hirsch, IJ Bigio, &#8220;Optimizing the probe geometry of elastic scattering spectroscopy for the diagnosis of prostate cancer&#8221;,\u00a0 Biomedical Optics conference of the Optical Society of America in Miami Beach, Florida (2004).<\/li>\n<\/ul>\n<p><strong>2003<\/strong><\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2011\/01\/Bigio-Aamar-Hirsch-2003.pdf\">IJ Bigio, O A&#8217;Amar, MS Hirsch, &#8220;Elastic scattering spectroscopy for detection of prostate cancer: preliminary feasibility study&#8221;<\/a>, Diagnostic Optical Spectroscopy in Biomedicine II,\u00a0Proc. SPIE5141: 142-146 (2003).<\/li>\n<\/ul>\n<p><strong>2002<\/strong><\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2011\/01\/Fluorescence_Aamar_Bigio_2002.pdf\">Ousama M A\u2019Amar and Irving J Bigio, \u201cCorrection of fluorescence spectra using data from elastic scattering spectroscopy and a modified Beer&#8217;s law.\u201d<\/a>Optical Society of America Topical Meetings, Miami (2002).<\/li>\n<\/ul>\n<p><strong> <\/strong><\/p>\n<p><strong>2001<\/strong><\/p>\n<ul>\n<li>O A&#8217;Amar, R Ley, P Ripley, I Bigio,\u00a0&#8220;In-vivo diagnosis of chemically induced melanoma in an animal model using UV-visible and NIR elastic-scattering spectroscopy: preliminary testing,&#8221; Proc. SPIE: Biomedical Diagnostic, Guidance and Surgical-Assist Systems,\u00a0Proc. SPIE\u00a04254: 144-150 (2001).<\/li>\n<\/ul>\n<p><strong>2000<\/strong><\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2011\/01\/Bigio-Bown-Kelley-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">I. J. Bigio, S.G. Bown, G. Briggs, S. Lakhani, D. Pickard, P.M. Ripley, I.G. Rose and C. Saunders\u00a0\u00a0&#8220;Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results&#8221;<\/a> Journal of Biomedical Optics\u00a05:\u00a0221-228 (2000)<\/li>\n<\/ul>\n<p><strong>1999<\/strong><\/p>\n<ul>\n<li>E Bossu, JJ Padilla, O\u00a0A&#8217;Amar, RM Parache, D\u00a0Notter, C Vigneron, F Guillemin, &#8220;Determination of endogenous porphyrins and the maximal HpD tumor\/normal skin ratio in SKH-1 hairless mice by light induced fluorescence spectroscopy,&#8221;\u00a0Artificial Cells Blood Substitutes and Immobilization Biotechnology\u00a027(2): 109-117 (1999).<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/mourant-johnson-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Judith R. Mourant, Tamara M. Johnson, Gerrit Los, Irving J. Bigio,\u00a0&#8220;Noninvasive measurement of chemotherapy drug concentrations in tissue: preliminary demonstrations of in vivo measurements&#8221;<\/a> Journal of Physics in Medicine and Biology\u00a044:1397-1417 (1999)<\/li>\n<\/ul>\n<p><strong>1998<\/strong><\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2011\/01\/Rezzoug-Bezdetnaya-Aamar-1998.pdf\">H Rezzoug, L Bezdetnaya, O\u00a0A&#8217;Amar, M Barberi-Heyob, JL Merlin, F. Guillemin, &#8220;Parameters affecting photodynamic activity of Foscan\u00ae or meta-tetra (hydroxyphenyl) chlorin (mTHPC) in vitro and in vivo,&#8221;<\/a> Lasers in Medical Science\u00a013(2): 119-125 (1998).<\/li>\n<\/ul>\n<p><strong>1997<\/strong><\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2011\/01\/bigio-mourant-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Irving J. Bigio, Judith R. Mourant\u00a0\u00a0&#8220;Ultraviolet and visible spectroscopies for tissue diagnostics: fluorescence spectroscopy and elastic-scattering spectroscopy&#8221;<\/a> Journal of Physics in Medicine and Biology\u00a042:\u00a0803-814 (1997)<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/Hielscher-mourant-bigio-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">A.H. Hielscher, J.R. Mourant, I. J. Bigio,\u00a0&#8220;Influence of particle size and concentration on the diffuse backscattering of polarized light from tissue phantoms and biological cell suspensions&#8221;<\/a> Applied Optics\u00a036:\u00a0125-135 (1997)<a href=\"\/bmo\/files\/2011\/01\/mourant-fuselier-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">J. R. Mourant, T. Fuselier, J. Boyer, T. Johnson, I. J. Bigio,\u00a0\u00a0&#8220;Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms&#8221;<\/a> Applied Optics36:\u00a0949-957 (1997)<\/li>\n<li>E Bossu, O\u00a0A&#8217;Amar, RM Parache, D\u00a0Notter, P Labrude, C Vigneron, F Guillemin, &#8220;Determination of the maximal tumor\/normal skin ratio after HpD or m-THPC administration in hairless mouse (Skh-1) by fluorescence spectroscopy, a non invasive method,&#8221;\u00a0Anti-Cancer Drugs\u00a08: 67-72 (1997).<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/Appl_Opt_Aug97_abs_meas.pdf\">Judith R. Mourant, Irving J. Bigio, Darren A. Jack, Tamara M. Johnson, and Heather D. Miller,\u00a0\u00a0&#8220;Measuring absorption coefficients in small volumes of highly scattering media: source-detector separations for which path lengths do not depend on scattering properties,&#8221; <\/a>Applied Optics\u00a036: 5655-5661 (1997).<\/li>\n<\/ul>\n<p><strong>1996<\/strong><\/p>\n<ul>\n<li><a href=\"\/bmo\/files\/2011\/01\/Bigio_Opt_Lett_96.pdf\">Judith R. Mourant, James Boyer, Andreas H. Hielscher, and Irving J. Bigio &#8220;Influence of the scattering phase function on light transport measurements in turbid media performed with small source\u2013detector separations&#8221;<\/a> Optics Letters\u00a021: 546-548 (1996).<\/li>\n<li><a href=\"\/bmo\/files\/2011\/01\/GI-paper-JBO_1996.pdf\">Judith R. Mourant, Irving J. Bigio, James Boyer, Tamara M. Johnson, JoAnne Lacey, Anthony G. Bohorfoush, and Mark Mellow,\u00a0 &#8220;Elastic Scattering Spectroscopy as a Diagnostic Tool for Differentiating Pathologies in the Gastrointestinal Tract: Preliminary Testing&#8221;,<\/a> Journal of Biomedical Optics\u00a01: 192-199 (1996).<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>2025 Ayman A Abdelhakeem,\u00a0Shuaibin Chang\u00a0, Anna Novoseltseva,\u00a0Mackenzie Hyman,\u00a0Ann C Mckee\u00a0,\u00a0Irving J Bigio,\u00a0David A Boas,\u00a0Bertrand R Huber,\u00a0Hui Wang, Quantitative analysis of lipofuscin in neurodegenerative diseases using serial sectioning two-photon microscopy and fluorescence lifetime imaging microscopy, Neurophotonics,\u00a02025 Jul;12(3):035007. Aslan, M., Gray, A.J., Packard, L. et al. Impact of uniform illumination in widefield microscopy and mesoscopy. Sci Rep [&hellip;]<\/p>\n","protected":false},"author":4139,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/bmo\/wp-json\/wp\/v2\/pages\/85"}],"collection":[{"href":"https:\/\/www.bu.edu\/bmo\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/bmo\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/bmo\/wp-json\/wp\/v2\/users\/4139"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/bmo\/wp-json\/wp\/v2\/comments?post=85"}],"version-history":[{"count":50,"href":"https:\/\/www.bu.edu\/bmo\/wp-json\/wp\/v2\/pages\/85\/revisions"}],"predecessor-version":[{"id":600,"href":"https:\/\/www.bu.edu\/bmo\/wp-json\/wp\/v2\/pages\/85\/revisions\/600"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/bmo\/wp-json\/wp\/v2\/media?parent=85"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}