{"id":590,"date":"2015-03-30T14:50:42","date_gmt":"2015-03-30T18:50:42","guid":{"rendered":"https:\/\/www.bu.edu\/biology\/?post_type=profile&#038;p=590"},"modified":"2026-05-01T16:08:23","modified_gmt":"2026-05-01T20:08:23","slug":"daniel-segre","status":"publish","type":"profile","link":"https:\/\/www.bu.edu\/biology\/people\/profiles\/daniel-segre\/","title":{"rendered":"Daniel Segr\u00e8"},"content":{"rendered":"<p style=\"text-align: center; font-size: 16px;\"><a class=\"button-primary\" href=\"http:\/\/www.bu.edu\/segrelab\/\" target=\"_blank\" rel=\"noopener noreferrer\">Lab Website<\/a><a class=\"button-primary\" href=\"\/biology\/files\/2017\/12\/Segre_CV_Dec5_2017_short.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">CV<\/a><a class=\"button-primary\" href=\"https:\/\/scholar.google.com\/citations?user=gWgEdEUAAAAJ&#038;hl=en\" target=\"_blank\" rel=\"noopener noreferrer\">Google<\/a><\/p>\n<h3>Current Research<\/h3>\n<p>We develop theoretical approaches and computational models for the study of complex biological networks. We are especially interested in the dynamics and evolution of metabolism, whose complex web of small-molecule transformations underlies fundamental aspects of biological organization, from energy transduction to cell-cell communication. In addition to helping understand how biological systems function and evolve, we seek to apply our methods to the design and optimization of engineered networks for bioenergy and biomedicine applications.<\/p>\n<h3>Selected Publications<\/h3>\n<ul>\n<li><span>Daniel Sher, Daniel Segr\u00e8, Michael J. Follows: Quantitative principles of microbial metabolism shared across scales,\u00a0\u00a0<\/span><b>Nature Microbiology<\/b><span>\u00a0(2024),\u00a0<\/span><b>9<\/b><span>,\u00a01940\u20131953. [<\/span><a data-auth=\"NotApplicable\" rel=\"noopener noreferrer\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41564-024-01764-0\" title=\"https:\/\/www.nature.com\/articles\/s41564-024-01764-0\" data-linkindex=\"0\" data-ogsc=\"\" id=\"anchor-50111c3a-3641-468e-23d2-af03819eb80c\">Nature Microbiology<\/a><span>]<\/span><\/li>\n<li><span>Michael R Silverstein, Jennifer M Bhatnagar, Daniel Segr\u00e8: Metabolic complexity drives divergence in microbial communities,\u00a0<\/span><b>Nature Ecology &amp; Evolution<\/b><span>\u00a0(2024),\u00a0<\/span><b>8<\/b><span>,\u00a0pages1493\u20131504. [<\/span><a data-auth=\"NotApplicable\" rel=\"noopener noreferrer\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41559-024-02440-6\" title=\"https:\/\/www.nature.com\/articles\/s41559-024-02440-6\" data-linkindex=\"1\" data-ogsc=\"\">Nature Ecol &amp; Evol<\/a><span>][<\/span><a data-auth=\"NotApplicable\" rel=\"noopener noreferrer\" target=\"_blank\" href=\"https:\/\/www.bu.edu\/hic\/2024\/10\/07\/gsf-michael-silverstein-seeks-to-engineer-new-microbial-communities-to-mitigate-climate-change\/\" title=\"https:\/\/www.bu.edu\/hic\/2024\/10\/07\/gsf-michael-silverstein-seeks-to-engineer-new-microbial-communities-to-mitigate-climate-change\/\" data-linkindex=\"2\" data-ogsc=\"\">Hariri Institute Article<\/a><span>]<\/span><\/li>\n<li><span>Charles Jo*, David B Bernstein*, Natalie Vaisman, Horacio M Frydman, Daniel Segr\u00e8: Construction and modeling of a co-culture microplate for real-time measurement of microbial interactions,\u00a0<\/span><b>mSystems<\/b><span>\u00a0(2023),\u00a0e00017-21.\u00a0[<\/span><a data-auth=\"NotApplicable\" rel=\"noopener noreferrer\" target=\"_blank\" href=\"https:\/\/journals.asm.org\/doi\/10.1128\/msystems.00017-21\" title=\"https:\/\/journals.asm.org\/doi\/10.1128\/msystems.00017-21\" data-linkindex=\"3\" data-ogsc=\"\">mSystems<\/a><span>]<\/span><\/li>\n<li>\n<p style=\"font-weight: 400;\"><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\">Michael Silverstein, Daniel Segr\u00e8, Jennifer M. Bhatnagar: Environmental microbiome engineering for the mitigation of climate change, <strong>Global Change Biology<\/strong> (2023), 00:1\u201317. <a href=\"https:\/\/doi.org\/10.1111\/gcb.16609\" data-ogsc=\"\">https:\/\/doi.org\/10.1111\/gcb.16609<\/a>. [<\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gcb.16609\" data-ogsc=\"\"><span data-ogsc=\"rgb(11, 122, 187)\" data-ogsb=\"white\">GCB<\/span><\/a><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\">]<\/span><\/p>\n<\/li>\n<li>\n<p style=\"font-weight: 400;\"><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\"><\/span><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\">Elena J. Forchielli, Daniel J. Sher, Daniel Segr\u00e8: Metabolic phenotyping of marine heterotrophs on refactored media reveals diverse metabolic adaptations and lifestyle strategies,\u00a0<strong>mSystems<\/strong>\u00a0(2022) e00070-22 [<\/span><a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/msystems.00070-22\" data-ogsc=\"\"><span data-ogsc=\"rgb(11, 122, 187)\" data-ogsb=\"white\">mSystems<\/span><\/a><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\">]<\/span><\/p>\n<\/li>\n<li>\n<p style=\"font-weight: 400;\"><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\"><\/span><span data-ogsc=\"rgb(37, 67, 0)\">Ilija Dukovski, Djordje Baji\u0107, Jeremy M Chac\u00f3n, Michael Quintin, Jean CC Vila, Snorre Sulheim, Alan R Pacheco, David B Bernstein, William J Rieh, Kirill S Korolev, Alvaro Sanchez, William R Harcombe, Daniel Segr\u00e8: A metabolic modeling platform for the computation of microbial ecosystems in time and space (COMETS),\u00a0<strong>Nature Protocols<\/strong>\u00a0(2021) <a href=\"https:\/\/doi.org\/10.1038\/s41596-021-00593-3\" data-ogsc=\"\">https:\/\/doi.org\/10.1038\/s41596-021-00593-3<\/a>. [<a href=\"https:\/\/www.nature.com\/articles\/s41596-021-00593-3\" data-ogsc=\"\">Nature Protocols<\/a>][<a href=\"https:\/\/t.co\/B56rp7DRXA?amp=1\" data-ogsc=\"\">Read PDF<\/a>]<\/span><\/p>\n<\/li>\n<li>\n<p style=\"font-weight: 400;\"><span data-ogsc=\"rgb(37, 67, 0)\"><\/span><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\">Alan R Pacheco, Melisa Osborne &amp; Daniel Segr\u00e8: Non-additive microbial community responses to environmental complexity,\u00a0<strong>Nature Communications\u00a0<\/strong>(2021) 12, 2365. [<\/span><span data-ogsc=\"black\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-021-22426-3\" data-ogsc=\"\">Nature Comm<\/a><\/span><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\">] [<\/span><span data-ogsc=\"black\"><a href=\"https:\/\/www.bu.edu\/articles\/2021\/moving-beyond-synthetic-biology-synthetic-ecology-seeks-to-boost-health-by-engineering-the-environment\/\" data-ogsc=\"\">The Brink news<\/a><\/span><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\">]<\/span><\/p>\n<\/li>\n<li>\n<p style=\"font-weight: 400;\"><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\"><\/span><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\">Joshua E. Goldford, Hyman Hartman, Robert Marsland III,\u00a0Daniel Segr\u00e8:\u00a0Environmental boundary conditions for the origin of life converge to an organo-sulfur metabolism,\u00a0<strong>Nature Ecology &amp; Evolution<\/strong>\u00a0(2019), doi:10.1038\/s41559-019-1018-8 [<\/span><span data-ogsc=\"black\"><a href=\"https:\/\/www.nature.com\/articles\/s41559-019-1018-8\" data-ogsc=\"\">Nature Ecol. &amp; Evol.<\/a><\/span><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\">][<\/span><span data-ogsc=\"black\"><a href=\"https:\/\/rdcu.be\/bWBls\" data-ogsc=\"\">SharedIt<\/a><\/span><span data-ogsc=\"rgb(37, 67, 0)\" data-ogsb=\"white\">]<\/span><\/p>\n<\/li>\n<\/ul>\n","protected":false},"author":8774,"template":"","_links":{"self":[{"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/profile\/590"}],"collection":[{"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/profile"}],"about":[{"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/types\/profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/users\/8774"}],"version-history":[{"count":23,"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/profile\/590\/revisions"}],"predecessor-version":[{"id":22843,"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/profile\/590\/revisions\/22843"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/media?parent=590"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}