{"id":10279,"date":"2019-12-16T11:56:52","date_gmt":"2019-12-16T16:56:52","guid":{"rendered":"http:\/\/www.bu.edu\/biology\/?post_type=profile&#038;p=10279"},"modified":"2026-04-29T15:28:00","modified_gmt":"2026-04-29T19:28:00","slug":"joe-larkin","status":"publish","type":"profile","link":"https:\/\/www.bu.edu\/biology\/people\/profiles\/joe-larkin\/","title":{"rendered":"Joe Larkin"},"content":{"rendered":"<p style=\"text-align: center; font-size: 16px;\"><a class=\"button-primary\" href=\"https:\/\/www.larkinlab.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">Lab Website<\/a><\/p>\n<h3>Current Research<\/h3>\n<p>Throughout evolutionary history, life has explored the laws of physics, creating remarkable new strategies to perpetuate itself. Our group seeks to understand how these strategies arise, using microbial populations as a model. We are interested in how the physical and chemical environment influences microbes, and how these microbes in turn engineer that very environment. In particular, we study how bacterial biofilms change their local conditions by producing extracellular matrix and how cell-to-cell signals drive such behaviors. We probe theoretical models of these phenomena with the goal of building toward an emergent understanding of living matter.<\/p>\n<p>Our group also has specific interest in how electrophysiology influences the behavior of bacteria, including through cell-to-cell communication, and control of both metabolism and gene expression.<\/p>\n<p>To investigate these problems, we use time-lapse imaging and custom experimental devices to observe and probe microbial behaviors in space and time.<\/p>\n<h3>Selected Publications<\/h3>\n<ul>\n<li>\n<div data-ogsc=\"black\"><span data-ogsc=\"\" data-olk-copy-source=\"MessageBody\">Brooks C, Yao M, McCool JT, Gillman A, S\u00fcel GM, Mugler A, and Larkin JW, \u201cComputational model of fractal interface formation in bacterial biofilms\u201d, Physical Review E, <a href=\"https:\/\/journals.aps.org\/pre\/abstract\/10.1103\/2zm9-r3qs\">10.1103\/2zm9-r3qs<\/a> (2025).<\/span><\/div>\n<\/li>\n<li>\n<div data-ogsc=\"black\"><span data-ogsc=\"\" data-olk-copy-source=\"MessageBody\"><\/span><span data-ogsc=\"\">Mulder OJ, Peters Kostman M, Almodaimegh A, Edge MD*, and Larkin JW*, \u201cAn agent-based model of metabolic signaling oscillations in Bacillus subtilis biofilms\u201d, PLOS Computational Biology, <a href=\"https:\/\/journals.plos.org\/ploscompbiol\/article?id=10.1371\/journal.pcbi.1013746\">10.1371\/journal.pcbi.1013746<\/a> (2025).<\/span><\/div>\n<ul>\n<li>\n<div data-ogsc=\"black\"><span data-ogsc=\"\">Featured on the <a title=\"https:\/\/journals.plos.org\/ploscompbiol\/issue?id=10.1371\/issue.pcbi.v21.i12\" id=\"OWA53b24902-783a-77f6-81e8-9ea34d3c9824\" data-auth=\"NotApplicable\" rel=\"noopener noreferrer\" target=\"_blank\" href=\"https:\/\/journals.plos.org\/ploscompbiol\/issue?id=10.1371\/issue.pcbi.v21.i12\" data-linkindex=\"2\" data-ogsc=\"\">cover<\/a>.<\/span><\/div>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<div data-ogsc=\"black\"><span data-ogsc=\"\"><\/span><span data-ogsc=\"\">Incandela JT, Hu K, Joshi P, Rosenstin JK, and Larkin JW, \u201cNon-optical, label-free electrical capacitance imaging of microorganisms\u201d, mBio, <a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.01676-25\">10.1128\/mbio.01676-25<\/a> (2025).<\/span><\/div>\n<\/li>\n<li>\n<div data-ogsc=\"black\"><span data-ogsc=\"\"><\/span><span data-ogsc=\"\">Abdelatty M, Incandela J, Hu K, Joshi P, Larkin JW, Reda S, and Rosenstein JK, \u201cElectrical Capacitance Tomography of Cell Cultures on a CMOS Microelectrode Array\u201c, IEEE Transactions on Biomedical Circuits and Systems, <a href=\"https:\/\/ieeexplore.ieee.org\/document\/10559749\">10.1109\/TBCAS.2024.3415360<\/a> (2024).<\/span><\/div>\n<\/li>\n<li>\n<div data-ogsc=\"black\"><span data-ogsc=\"\"><\/span><span data-ogsc=\"\">Hu K, Incandela J, Lian X, Larkin JW, Rosenstein JK, \u201cA 13.1 mm2 512 x 256 Multimodal CMOS Array for Spatiochemical Imaging of Bacterial Biofilms\u201d, <a href=\"https:\/\/ieeexplore.ieee.org\/document\/9772787\">10.1109\/CICC53496.2022.9772787<\/a>, IEEE CICC (2022).\u00a0<\/span><\/div>\n<\/li>\n<li>\n<div data-ogsc=\"black\"><span data-ogsc=\"\"><\/span><span data-ogsc=\"\">Yang C*, Bialecka-Fornal M.*, Weatherwax C, Larkin JW, Prindle A, Liu J, Garcia-Ojalvo J, Su\u0308el GM, \u201cEncoding membrane potential-based memory within a microbial community\u201c, Cell Systems, 10, <a href=\"https:\/\/www.cell.com\/cell-systems\/fulltext\/S2405-4712(20)30116-2\">417-423<\/a> (2020).\u00a0<\/span><\/div>\n<\/li>\n<li>Larkin J, Zhai XL, Kikuchi K, Redford SE, Prindle A, Liu J, Greenfield S, Walczak AM, Garcia-Ojalvo J, Mugler A, and S\u00fcel G, &#8220;Signal Percolation within a Bacterial Community&#8221;, <em>Cell Syst.<\/em> 7: <a href=\"https:\/\/www.cell.com\/fulltext\/S2405-4712(18)30245-X\" target=\"_blank\" rel=\"noopener noreferrer\">1-9.<\/a> (2018)<\/li>\n<\/ul>\n","protected":false},"author":10204,"template":"","_links":{"self":[{"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/profile\/10279"}],"collection":[{"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/profile"}],"about":[{"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/types\/profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/users\/10204"}],"version-history":[{"count":5,"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/profile\/10279\/revisions"}],"predecessor-version":[{"id":22791,"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/profile\/10279\/revisions\/22791"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/biology\/wp-json\/wp\/v2\/media?parent=10279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}