{"id":3537,"date":"2012-09-19T10:28:22","date_gmt":"2012-09-19T14:28:22","guid":{"rendered":"https:\/\/www.bu.edu\/bioinformatics\/?page_id=3537"},"modified":"2025-09-08T15:31:32","modified_gmt":"2025-09-08T19:31:32","slug":"faculty-research","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/bioinformatics\/research\/faculty-research\/","title":{"rendered":"Faculty Research"},"content":{"rendered":"

The Graduate Program in Bioinformatics offers unique interdisciplinary training in the science, engineering, medicine and ethics of twenty-first-century systems biology. The Program is University-wide and includes Faculty from the Colleges of Engineering, Arts and Sciences, components of the Medical campus including the National Emerging Infectious Disease Laboratory (NEIDL), and adjunct faculty from major biotechnology companies, the Broad Institute, Harvard Medical School\u00a0 and the National Institutes of Health. View the full list of Faculty \u203a<\/a><\/p>\n

\n

SPOTLIGHT
\nDaniel Segr\u00e8, Ph.D.<\/strong>
\n\"Segre\"<\/a>Professor, Bioinformatics
\nProfessor, Biology,<\/em> Biomedical Engineering, Physics<\/em>
\nDirector, BU Microbiome Initiative, Co-Director, BU ARC on Systems Biology of Microbiomes<\/em><\/p>\n

Dr. Segr\u00e8\u2019s laboratory research<\/a> interests focus on the evolutionary dynamics of biological networks, in particular in the interplay between response to genetic and environmental perturbations, genomic-level functional organization, and optimal adaptation. His research lab is especially interested in developing constraint-based models to study the regulatory and evolutionary dynamics of metabolic networks across different organisms, cell types, and interacting cell populations.<\/p>\n

Research Interests<\/b>
\n\u2022 Computational Systems Biology
\n\u2022 Evolutionary Dynamics of Biochemical Networks
\n\u2022 Microbial Metabolism
\n\u2022 Origins of Life and Bioenergetics<\/p>\n

\n

SPOTLIGHT
\nJosh Campbell, Ph.D.<\/strong><\/p>\n

\"\"Assistant Professor, Division of Computational Biomedicine<\/em>
\nAssistant Professor, Bioinformatics<\/em>
\nBioinformatics Program Director<\/em><\/p>\n

Research Interests<\/b>
\n\u2022 Computational biology and bioinformatics
\n\u2022 Identifying early drivers of lung cancer
\n\u2022 Therapeutic development and pathogenesis of COPD<\/p>\n

 <\/p>\n

Dr. Campbell’s laboratory’s research focus is to understand the effect of carcinogenic exposures on the airway, elucidate the mechanisms that cause the development of pre-cancerous lesions in the lung, and to uncover the biological underpinnings of cancer disparities. Dr. Campbell is also an alumnus of\u00a0 our PhD\u00a0Graduate Program Bioinformatics.<\/span><\/p>\n

\n

SPOTLIGHT
\nKirill Korolev, Ph.D.<\/strong>
\n\"Korolev\"<\/a>Associate Professor, Bioinformatics
\nAssociate Professor, Physics<\/em><\/p>\n

Research Interests<\/b>
\n\u2022 Evolutionary Dynamics of Cancer
\n\u2022 Early Warning Signals of Population Collapse
\n\u2022 Evolution of Microbial Populations<\/p>\n

Korolev Research Group\u203a<\/a><\/p>\n

 <\/p>\n

\n

SPOTLIGHT
\nAvrum Spira, M.D., M.Sc.<\/strong>
\n\"Spira\"<\/a>Professor of Medicine, Pathology and Laboratory Medicine<\/em>
\nProfessor of Bioinformatics<\/em>
\nDirector, Boston University \u2013 Boston Medical Center Cancer Center<\/em>
\nChief, Division of Computational Biomedicine<\/em>
\n Director, Translational Bioinformatics Program, Clinical and Translational Science Institute<\/em><\/p>\n

Dr. Spira\u2019s laboratory research<\/a> interests focus on applying high-throughput genomic and bioinformatics tools\u00a0(including microarrays and RNA-seq)\u00a0to the translational study of lung cancer and Chronic Obstructive Lung Disease (COPD).\u00a0 The primary research focus of\u00a0his lab is to determine how cigarette smoking affects intra-thoracic (lobar bronchi and lung parenchyma) and extra-thoracic (mouth and nasal) airway epithelial cell gene expression and to use this information to develop non-invasive genomic biomarkers for lung cancer (and other smoking-related lung diseases)\u00a0that can identify that subset of smokers\u00a0at risk and potentially guide therapeutic and preventive strategies for these diseases.\u00a0 With a $13.6 million grant from the Department of Defense awarded in 2011, Dr. Spira is carrying the research forward as leader of a five-year study called Detecting Early Lung Cancer Among Military Personnel<\/em> (DECAMP). Dr. Spira is also an alumnus of\u00a0 our MS\u00a0Graduate Program Bioinformatics.<\/span><\/p>\n

Research Interests<\/b>
\n\u2022 Lung Cancer and COPD Genomics
\n\u2022 Smoking and Airway Gene Expression
\n\u2022 Bioinformatics
\n\u2022 Critical Care Medicine
\n\u2022 Pulmonary Medicine<\/p>\n

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The Graduate Program in Bioinformatics offers unique interdisciplinary training in the science, engineering, medicine and ethics of twenty-first-century systems biology. The Program is University-wide and includes Faculty from the Colleges of Engineering, Arts and Sciences, components of the Medical campus including the National Emerging Infectious Disease Laboratory (NEIDL), and adjunct faculty from major biotechnology companies, […]<\/p>\n","protected":false},"author":6157,"featured_media":0,"parent":2200,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/bioinformatics\/wp-json\/wp\/v2\/pages\/3537"}],"collection":[{"href":"https:\/\/www.bu.edu\/bioinformatics\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/bioinformatics\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/bioinformatics\/wp-json\/wp\/v2\/users\/6157"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/bioinformatics\/wp-json\/wp\/v2\/comments?post=3537"}],"version-history":[{"count":50,"href":"https:\/\/www.bu.edu\/bioinformatics\/wp-json\/wp\/v2\/pages\/3537\/revisions"}],"predecessor-version":[{"id":10091,"href":"https:\/\/www.bu.edu\/bioinformatics\/wp-json\/wp\/v2\/pages\/3537\/revisions\/10091"}],"up":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/bioinformatics\/wp-json\/wp\/v2\/pages\/2200"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/bioinformatics\/wp-json\/wp\/v2\/media?parent=3537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}