Trevor Siggers

The goal of my laboratory’s research is a systems-level understanding of immune cell responses through integrative proteomic and genomic study of transcription factors (TFs). It is our vision that a biophysical understanding of TF function combined with genome-scale data will lead to quantitative models that can describe immune signaling in healthy and disease states. We have current projects investigating the interferon regulatory factors (IRF) proteins that regulate the anti-viral response, the type II nuclear receptors that coordinate metabolism and inflammation, and the macrophage lineage factors PU.1 and IRF8. My lab also works to develop new high-throughput proteomic approaches to study TF complexes that regulate genes.