Samagya Banskota
Precision genome editing technologies can potentially treat the root causes of several genetic diseases by making precise and targeted edits to the DNA. However, safe and effective delivery methods are needed to translate this potential into a therapeutic reality. My lab’s research interests lie in the intersection of synthetic biology, protein engineering, drug delivery, and […]
Cynthia A. Bradham
Our research is focused on understanding secondary (dorsal-ventral) axis specification and skeletal patterning in the sea urchin. We are interested in producing a systems-level description for these processes. Sea urchin, a non-chordate deuterostome, is an ideal model organism for systems-level developmental studies. Genomic analysis has revealed that sea urchins share the diversity of signaling and […]
Christopher Chen
One of the world’s leading experts on regenerative medicine, Chen investigates tissue engineering and mechanobiology, which combines engineering and biology to study how physical forces and changes in cell or tissue mechanics affect development, physiology, and disease. In particular, Chen is studying the cooperation between adhesive, mechanical, and biochemical signaling in the regulation of angiogenesis […]
Brian Cleary
Our group works at the interface of the limits of algorithmic learning and the limits of biological experimentation in pursuit of the organizing principles of molecular, cellular and tissue processes. A central vision of the lab is to study cellular pathways and tissue biology at scales that appear impossible to achieve, but which in fact […]
Douglas Densmore
A computer engineer, Densmore’s research focuses on the development of tools for the specification, design, and assembly of synthetic biological systems, drawing upon his experience with embedded system-level design and electronic design automation. He is also the director of the Cross-disciplinary Integration of Design Automation Research group at the University, where his research team develops computational and […]
Mary Dunlop
The Dunlop Lab uses approaches from Synthetic Biology and Systems Biology to quantitatively understand and engineer cellular processes. We are especially interested in how microbes use feedback, and also in engineering novel feedback loops. We use both experimental and theoretical approaches to study these complex biological systems.
Juan Fuxman Bass
Our lab studies the mechanisms controlling the expression of immune genes. Transcriptional regulation plays a fundamental role in proper immune development and homeostasis as well as in mounting immune responses against pathogens. Indeed, mutations in the regulatory regions of immune genes such as cytokines, receptors and signaling molecules have been associated with multiple pathologies including […]
Alexander Green
The Green lab applies the principles of self-assembly to develop new techniques for programming and probing biology. We use in silico tools to design RNA molecules from scratch that respond to stimuli and execute biomolecular programs in living cells. We engineer nucleic acids that sense and amplify molecular cues to develop diagnostic assays that are […]
Liang Hao
Precision medicine has transformative impact in managing heterogeneous disorders including cancer, metabolic, and neurological diseases. At the living interface of precision engineering and health, the Hao laboratory will develop molecular and cellular tools to precisely track and control disease biology in intact organisms. Our specific research interests include (1) noninvasive disease detection and treatment monitoring […]
Miguel Jimenez
The capacity of living cells to continuously monitor and act on their environment with molecular specificity is unmatched by any sensor or actuator developed by humans. We have shown that it is possible to use genetically engineered microorganisms as the sensing and actuation elements in electronic and mechanical devices. These integrated microbial devices outperform traditional […]