Brian Cleary
Our group works at the interface of the limits of algorithmic learning and the limits of biological experimentation in pursuit of the organizing principles of molecular, cellular and tissue processes. A central vision of the lab is to study cellular pathways and tissue biology at scales that appear impossible to achieve, but which in fact […]
Ana Fiszbein
My lab studies how transcription and RNA splicing are coordinated to control gene expression, and how these mechanisms can be harnessed therapeutically. We investigate how promoters, transcription factors, transcription and splicing dynamics, and splicing factors shape alternative RNA processing and protein isoform production across development, cancer, aging, neurodegeneration, and genetic diseases. By combining functional genomics, […]
Pawel Przytycki
It is becoming increasingly clear that complex genetic diseases manifest differently in each person, tissue, and even cell, and that many of these differences are driven by subtle changes in gene regulation. Vast amounts of multi-modal data are therefore needed to understand how these diseases function and progress. As the scale and complexity of data […]