Cynthia A. Bradham
Our research is focused on understanding secondary (dorsal-ventral) axis specification and skeletal patterning in the sea urchin. We are interested in producing a systems-level description for these processes. Sea urchin, a non-chordate deuterostome, is an ideal model organism for systems-level developmental studies. Genomic analysis has revealed that sea urchins share the diversity of signaling and […]
Brian Cleary
Our group works at the interface of the limits of algorithmic learning and the limits of biological experimentation in pursuit of the organizing principles of molecular, cellular and tissue processes. A central vision of the lab is to study cellular pathways and tissue biology at scales that appear impossible to achieve, but which in fact […]
Juan Fuxman Bass
Our lab studies the mechanisms controlling the expression of immune genes. Transcriptional regulation plays a fundamental role in proper immune development and homeostasis as well as in mounting immune responses against pathogens. Indeed, mutations in the regulatory regions of immune genes such as cytokines, receptors and signaling molecules have been associated with multiple pathologies including […]
Joseph William Larkin
Throughout evolutionary history, life has explored the laws of physics, creating remarkable new strategies to perpetuate itself. Our group seeks to understand how these strategies arise, using microbial populations as a model. We are interested in how the physical and chemical environment influences microbes, and how these microbes in turn engineer that very environment. In […]
Daniel Segre
We develop theoretical approaches and computational models for the study of complex biological networks. We are especially interested in the dynamics and evolution of metabolism, whose complex web of small-molecule transformations underlies fundamental aspects of biological organization, from energy transduction to cell-cell communication. In addition to helping understand how biological systems function and evolve, we […]
Trevor Siggers
The goal of my laboratory’s research is a systems-level understanding of immune cell responses through integrative proteomic and genomic study of transcription factors (TFs). It is our vision that a biophysical understanding of TF function combined with genome-scale data will lead to quantitative models that can describe immune signaling in healthy and disease states. We have […]
Zeba Wunderlich
Regulatory DNA encodes the gene regulatory networks that are required for virtually every process in an animal, from development to immunity. The Wunderlich lab is interested in understanding how a gene regulatory network’s tasks influence its architecture, robustness, and evolvability. To probe these questions, we use two model systems: the Drosophila early embryonic patterning system […]