{"id":967,"date":"2005-07-01T10:22:00","date_gmt":"2005-07-01T14:22:00","guid":{"rendered":"http:\/\/jaydub.cms-devl.bu.edu\/aodhealth\/2005\/01\/01\/inherited-differences-in-metabolism-influence-risk-of-alcohol-dependence\/"},"modified":"2017-01-31T11:47:12","modified_gmt":"2017-01-31T16:47:12","slug":"inherited-differences-in-metabolism-influence-risk-of-alcohol-dependence","status":"publish","type":"post","link":"https:\/\/www.bu.edu\/aodhealth\/2005\/07\/01\/inherited-differences-in-metabolism-influence-risk-of-alcohol-dependence\/","title":{"rendered":"Inherited   Differences in Metabolism Influence Risk of Alcohol Dependence"},"content":{"rendered":"<div class=\"research-summary-body\">\n                    <!-- InstanceBeginEditable name=\"contents\" -->  <\/p>\n<p>About 50%<br \/>\n  of a person&#8217;s risk for alcohol dependence is determined<br \/>\n  by genetics. Emerging research suggests that this propensity<br \/>\n  toward dependence may result from inherited differences<br \/>\n  in metabolism. <\/p>\n<ul>\n<li>Chai<br \/>\n  and colleagues genotyped 24 Korean men with the early-onset,<br \/>\n  familial form of alcoholism (Type II), 48 with late-onset<br \/>\n  alcoholism (Type I), and 38 healthy controls. They found<br \/>\n  that                           <\/li>\n<\/ul>\n<ul>\n<ul style=\"margin-bottom: 0\">\n<li>high-active<br \/>\n  forms of the alcohol dehydrogenases ADH2 and ADH3,<br \/>\n  which convert ethanol to acetate and acetaldehyde<br \/>\n  (a toxin that causes flushing and other unpleasant<br \/>\n  symptoms) were significantly more common in healthy<br \/>\n  controls and men with late-onset alcoholism than in<br \/>\n  men with early-onset familial alcoholism; <\/li>\n<li>active<br \/>\n  forms of aldehyde dehydrogenase ALDH2, which clears<br \/>\n  the toxin acetaldehyde, were significantly less common<br \/>\n  in healthy controls than in men with either type of<br \/>\n  alcoholism. <\/li>\n<\/ul>\n<\/ul>\n<ul>\n<li>Guindalini<br \/>\n  et al genotyped 92 patients with alcoholism and 92 healthy<br \/>\n  subjects, and reported that<\/li>\n<\/ul>\n<ul>\n<ul style=\"margin-bottom: 0\">\n<li>the<br \/>\n  healthy subjects were significantly more likely to<br \/>\n  have 2 alleles associated with more active (and protective)<br \/>\n  forms of the alcohol dehydrogenase ADH4 than were<br \/>\n  patients with alcoholism.<\/li>\n<\/ul>\n<\/ul>\n<p><!-- InstanceEndEditable --><\/p>\n<div class=\"research-summary-footnotes-1\">\n\t\t\t\t\t\t<!-- InstanceBeginEditable name=\"footnotes-1\" --><!-- InstanceEndEditable -->\n\t\t\t\t\t<\/div>\n<h2 class=\"research-summary-comments\">Comments:<\/h2>\n<p>\t\t\t\t\t<!-- InstanceBeginEditable name=\"comments\" -->  <\/p>\n<p>A<br \/>\n  metabolic predisposition to produce and accumulate acetaldehyde<br \/>\n  is protective against alcohol dependence, and these studies<br \/>\n  have isolated specific genetic targets. After further<br \/>\n  verification in larger samples, these findings hold great<br \/>\n  promise for genetic testing and targeted prevention, medication<br \/>\n  development, and even genetic therapy. <\/p>\n<p>  <!-- InstanceEndEditable --><br \/>\n                    <cite><br \/>\n\t\t\t\t\t\t<!-- InstanceBeginEditable name=\"name\" -->  Peter<br \/>\n  D. Friedmann, MD, MPH<!-- InstanceEndEditable --><br \/>\n\t\t\t\t\t<\/cite><\/p>\n<div class=\"research-summary-footnotes\">\n\t\t\t\t\t<!-- InstanceBeginEditable name=\"footnotes\" --><!-- InstanceEndEditable -->\n\t\t\t\t\t<\/div>\n<h2>Reference:<\/h2>\n<p>\t\t\t\t\t<!-- InstanceBeginEditable name=\"reference\" -->  <\/p>\n<p>Chai<br \/>\n  YG, Oh DY, Chung EK, et al. <a href=\"http:\/\/ajp.psychiatryonline.org\/cgi\/content\/abstract\/162\/5\/1003?maxtoshow=&amp;HITS=10&amp;hits=10&amp;RESULTFORMAT=1&amp;author1=chai&amp;andorexacttitle=and&amp;andorexacttitleabs=and&amp;andorexactfulltext=and&amp;searchid=1120224287670_1934&amp;stored_search=&amp;FIRSTINDEX=0&amp;sortspec=relevance&amp;journalcode=ajp\" target=\"_blank\">Alcohol and aldehyde dehydrogenase<br \/>\n  polymorphisms in men with type I and type II alcoholism<\/a>.<br \/>\n  <em>Am J Psychiatry. <\/em> 2005;162(5):1003-1005. <\/p>\n<p>Guindalini<br \/>\n  C, Scivoletto S, Ferreira RGM, et al. <a href=\"http:\/\/ajp.psychiatryonline.org\/cgi\/content\/abstract\/162\/5\/1005?maxtoshow=&amp;HITS=10&amp;hits=10&amp;RESULTFORMAT=&amp;author1=Guindalini&amp;andorexactfulltext=and&amp;searchid=1120057972556_2181&amp;stored_search=&amp;FIRSTINDEX=0&amp;sortspec=relevance&amp;resourcetype=1&amp;journalcode=ajp\" target=\"_blank\">Association of genetic<br \/>\n  variants of alcohol dehydrogenase 4 with alcohol dependence<br \/>\n  in Brazilian patients.<\/a> <em>Am J Psychiatry. <\/em> 2005;162(5):1005-1007.<\/p>\n<p>  <!-- InstanceEndEditable -->\n\t\t\t\t<\/div>\n","protected":false},"excerpt":{"rendered":"<p>About 50% of a person&#8217;s risk for alcohol dependence is determined by genetics. Emerging research suggests that this propensity toward dependence may result from inherited differences in metabolism. Chai and colleagues genotyped 24 Korean men with the early-onset, familial form of alcoholism (Type II), 48 with late-onset alcoholism (Type I), and 38 healthy controls. They [&hellip;]<\/p>\n","protected":false},"author":11272,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[80],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/posts\/967"}],"collection":[{"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/users\/11272"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/comments?post=967"}],"version-history":[{"count":1,"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/posts\/967\/revisions"}],"predecessor-version":[{"id":3103,"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/posts\/967\/revisions\/3103"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/media?parent=967"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/categories?post=967"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/tags?post=967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}