{"id":244,"date":"2014-03-01T10:12:00","date_gmt":"2014-03-01T14:12:00","guid":{"rendered":"http:\/\/jaydub.cms-devl.bu.edu\/aodhealth\/2014\/01\/01\/midlife-alcohol-consumption-and-cognitive-decline\/"},"modified":"2017-01-31T11:45:09","modified_gmt":"2017-01-31T16:45:09","slug":"midlife-alcohol-consumption-and-cognitive-decline","status":"publish","type":"post","link":"https:\/\/www.bu.edu\/aodhealth\/2014\/03\/01\/midlife-alcohol-consumption-and-cognitive-decline\/","title":{"rendered":"Midlife Alcohol Consumption  and Cognitive Decline"},"content":{"rendered":"<div class=\"research-summary-body\">\n                    <!-- InstanceBeginEditable name=\"contents\" --><\/p>\n<p>Some  researchers suggest that lower-risk alcohol use may be associated with better  cognitive function, but the impact of alcohol use on cognitive aging  trajectories is not well known. This study examined the association between  midlife alcohol use (assessed 3 times over a 10-year period) and cognitive  decline (3 waves of cognitive assessment in the next 10-year period) in 5054  men and 2099 women (mean age=56), measuring global cognitive function, executive  function, and memory.<\/p>\n<ul>\n<li>Men  with an average daily consumption of \u226536 g of alcohol showed a significantly  faster decline on all cognitive measures compared with those with an average  daily consumption of 0.1\u201319.9 g. The effect size was comparable to 2.4 extra  years of decline for global cognitive function, 1.5 for executive function, and  5.7 for memory. There were no differences observed between 10-year abstainers,  those who ceased alcohol use within the last 10 years, those with occasional alcohol  use, those with an average daily consumption of 20\u201335.9 g, and those with an  average daily consumption of 0.1\u201319.9 g.<\/li>\n<li>In  women, 10-year abstainers showed a faster decline in global cognitive function  and executive function compared with those with an average daily consumption of  0.1\u20139.9 g. There were no other statistically significant differences between  groups.<\/li>\n<\/ul>\n<p><!-- InstanceEndEditable --><\/p>\n<div class=\"research-summary-footnotes-1\">\n\t\t\t\t\t\t<!-- InstanceBeginEditable name=\"footnotes-1\" --><\/p>\n<p>Note: Analyses were adjusted for age,  ethnicity, education, occupation, marital status, smoking history, physical  activity level, time since first cognitive evaluation, and interaction between  each covariate and time.<\/p>\n<p>\t\t\t\t\t<!-- InstanceEndEditable -->\n\t\t\t\t\t<\/div>\n<h2 class=\"research-summary-comments\">Comments:<\/h2>\n<p>\t\t\t\t\t<!-- InstanceBeginEditable name=\"comments\" -->In men, heavy alcohol use in midlife appears to be harmful to cognitive  function, and no benefit was found for light to moderate use. Among women,  abstainers showed a faster cognitive decline, but the number of abstainers was  small and residual confounding is likely. No differences were observed among women  with alcohol use, even though some results suggested that those with heavier use  might experience a faster cognitive decline.<!-- InstanceEndEditable --><br \/>\n                    <cite><br \/>\n\t\t\t\t\t\t<!-- InstanceBeginEditable name=\"name\" -->Nicolas Bertholet,  MD, MSc<!-- InstanceEndEditable --><br \/>\n\t\t\t\t\t<\/cite><\/p>\n<div class=\"research-summary-footnotes\">\n\t\t\t\t\t<!-- InstanceBeginEditable name=\"footnotes\" --><!-- InstanceEndEditable -->\n\t\t\t\t\t<\/div>\n<h2>Reference:<\/h2>\n<p>\t\t\t\t\t<!-- InstanceBeginEditable name=\"reference\" -->Sabia S, Elbaz A, Britton A, et al. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24431298\">Alcohol consumption and cognitive  decline in early old age<\/a>. <em>Neurology<\/em>.  2014:28;82(4):332\u2013339.<!-- InstanceEndEditable -->\n\t\t\t\t<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Some researchers suggest that lower-risk alcohol use may be associated with better cognitive function, but the impact of alcohol use on cognitive aging trajectories is not well known. This study examined the association between midlife alcohol use (assessed 3 times over a 10-year period) and cognitive decline (3 waves of cognitive assessment in the next [&hellip;]<\/p>\n","protected":false},"author":11272,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[33],"tags":[77],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/posts\/244"}],"collection":[{"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/users\/11272"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/comments?post=244"}],"version-history":[{"count":1,"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/posts\/244\/revisions"}],"predecessor-version":[{"id":2164,"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/posts\/244\/revisions\/2164"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/media?parent=244"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/categories?post=244"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bu.edu\/aodhealth\/wp-json\/wp\/v2\/tags?post=244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}