{"id":9,"date":"2012-06-07T15:38:57","date_gmt":"2012-06-07T19:38:57","guid":{"rendered":"https:\/\/www.bu.edu\/alpha-1\/?page_id=9"},"modified":"2021-03-15T13:04:47","modified_gmt":"2021-03-15T17:04:47","slug":"research","status":"publish","type":"page","link":"https:\/\/www.bu.edu\/alpha-1\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div id=\"banner\">\n<p><script src=\"http:\/\/www.bu.edu\/nis\/lib\/jquery\/crossslide.js\" type=\"text\/javascript\"><\/script><script type=\"text\/javascript\">\/\/ <![CDATA[ jQuery(document).ready(function($) { $('#bannerimage').crossSlide({ sleep: 5, fade: 2, shuffle: 0 }, [ { src: '\/alpha-1\/files\/2012\/06\/IMG_3857-400x300.jpg' }, { src: '\/alpha-1\/files\/2012\/06\/0811111-day-20-20x-image-1-400x300-jpg.jpg' }, { src: '\/alpha-1\/files\/2012\/06\/Julie-Pic-400x300.jpg' }, { src: '\/alpha-1\/files\/2012\/06\/Andrew-in-lab-400x300.jpg' } ]); }); \/\/ ]]><\/script><\/p>\n<div id=\"bannerimage\" class=\"alignleft\" style=\"height: 300px; width: 400px; text-align: left;\"><img src=\"https:\/\/www.bu.edu\/alpha-1\/files\/2012\/06\/IMG_3857-250x300.jpg\" alt=\"\" \/><\/div>\n<\/div>\n<p style=\"text-align: left;\">Located in the Pulmonary Center and in conjunction with the Center \u00a0for Regenerative Medicine\u00a0<a href=\"http:\/\/www.bumc.bu.edu\/stemcells\/\">(CReM)<\/a>, the\u00a0Kotton\u00a0and\u00a0Wilson <a href=\"https:\/\/www.bu.edu\/dbin\/stemcells\/lab_wilson.php\">laboratories<\/a> focus on understanding alpha-1 associated lung and liver disease, with the goal of helping to develop cures for this disease in the future.\u00a0 We model AAT deficiency lung and liver disease using induced pluripotent stem\u00a0cells (iPS) that we have created from PiZZ alphas here at Boston Medical Center.\u00a0 In hopes of contributing to a future cure, our work has also focused on gene therapy and the development of a transplantable, bioartificial lung.<\/p>\n<h3><img class=\"alignnone size-full wp-image-1267\" title=\"100-3 undiff airway slice recell with AAW mods pic\" src=\"\/alpha-1\/files\/2012\/06\/100-3-undiff-airway-slice-recell-with-AAW-mods-pic-jpg.jpg\" alt=\"100-3 undiff airway slice recell with AAW mods pic\" \/><\/h3>\n<p><img loading=\"lazy\" class=\"alignnone size-full wp-image-134\" src=\"\/alpha-1\/files\/2012\/06\/Elastase-images-for-website.png\" alt=\"Elastase images for website\" width=\"1426\" height=\"458\" srcset=\"https:\/\/www.bu.edu\/alpha-1\/files\/2012\/06\/Elastase-images-for-website.png 1426w, https:\/\/www.bu.edu\/alpha-1\/files\/2012\/06\/Elastase-images-for-website-636x204.png 636w, https:\/\/www.bu.edu\/alpha-1\/files\/2012\/06\/Elastase-images-for-website-1024x328.png 1024w\" sizes=\"(max-width: 1426px) 100vw, 1426px\" \/><\/p>\n<h3>Selected Publications:<\/h3>\n<ol>\n<li><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/stem.495\/full\">Somers A, Jean JC, Sommer CA, Omari A, Ford CC, Mills JA, Ying L, Sommer AG, Jean JM, Smith BW, Lafyatis R, Demierre MF, Weiss DJ, French DL, Gadue P, Murphy GJ, Mostoslavsky G, Kotton DN: \u201cGeneration of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.\u201d Stem Cells. 2010 Oct;28(10):1728-40. PMID:20715179<\/a><\/li>\n<li><a href=\"http:\/\/www.nature.com\/nm\/journal\/v16\/n8\/full\/nm.2193.html\">Ott HC, Clippinger B, Conrad C, Schuetz C, Pomerantseva I, Ikonomou L, Kotton D, Vacanti JP: \u201cRegeneration and orthotopic transplantation of a bioartificial lung.\u201d Nat Med. 2010 Aug;16(8):927-33. PMID: 20628374<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2798672\/?tool=pubmed\">Wilson AA, Murphy GJ, Hamakawa H, Kwok LW, Srinivasan S, Hovav AH, Mulligan RC, Amar S, Suki B, and Kotton DN: \u201cAmelioration of emphysema in mice via lentiviral transduction of long-lived pulmonary alveolar macrophages.\u201d J Clin Invest. 120:379-89, 2010. PMID: 20038801<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2542452\/?tool=pubmed\">Wilson AA, Kwok LW, Hovav AH, Ohle SJ, Little FF, Fine A, and Kotton DN: \u201cSustained expression of \u03b1 1-antitrypsin after transplantation of manipulated hematopoietic stem cells.\u201d<\/a> <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2542452\/?tool=pubmed\">Am J Respir Cell Mol Biol. 39:133-41, 2008. PMID: 18323534<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Located in the Pulmonary Center and in conjunction with the Center \u00a0for Regenerative Medicine\u00a0(CReM), the\u00a0Kotton\u00a0and\u00a0Wilson laboratories focus on understanding alpha-1 associated lung and liver disease, with the goal of helping to develop cures for this disease in the future.\u00a0 We model AAT deficiency lung and liver disease using induced pluripotent stem\u00a0cells (iPS) that we have [&hellip;]<\/p>\n","protected":false},"author":6187,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bu.edu\/alpha-1\/wp-json\/wp\/v2\/pages\/9"}],"collection":[{"href":"https:\/\/www.bu.edu\/alpha-1\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bu.edu\/alpha-1\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/alpha-1\/wp-json\/wp\/v2\/users\/6187"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bu.edu\/alpha-1\/wp-json\/wp\/v2\/comments?post=9"}],"version-history":[{"count":50,"href":"https:\/\/www.bu.edu\/alpha-1\/wp-json\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":1363,"href":"https:\/\/www.bu.edu\/alpha-1\/wp-json\/wp\/v2\/pages\/9\/revisions\/1363"}],"wp:attachment":[{"href":"https:\/\/www.bu.edu\/alpha-1\/wp-json\/wp\/v2\/media?parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}