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Exon/Intron |
Trivial Name |
Codon |
Nucleotide Change* |
Codon Changed |
Systematic(cDNA based) |
Systematic (genomic based) |
Other names |
Type |
Consequence |
Validaton |
Frequency |
Comments |
Reference |
|
|
2 |
M-1T |
-1 |
CCATGGC>CCACGGC |
Met>Thr |
c.2T>C |
g.4895T>C |
M1T |
transition |
missense |
DNA only |
private |
initiation codon |
Ali
et al, 1993 |
|
2 |
R3Op |
3 |
CACCGAT>CACTGAT |
Arg>Opal |
c.10C>T |
g.4903C>T |
R3X, R3ter |
transition |
nonsense |
DNA only |
private |
CpG dinucleotide, opal stop codon |
Ali
et. al., 1994b |
|
2 |
A20 |
20 |
CCC[A]GAG>CCCGAG |
Gln>Arg (fs) |
c.62delA |
g.4955delA (first base of deletion) |
A20 |
deletion |
frameshift |
DNA only |
0.002 |
only in Italy |
Santamaria,
1996 |
|
IVS2 |
IVS2-1G>A |
|
atagGTA>ataaGTA |
|
|
g.5814G>A |
c.113-1G>A |
transition |
splicing defect |
DNA only |
private |
|
Santer,
2005 |
|
3 |
IVS2-14 |
37-38 |
ata[gGTA]CCA>ataCCA |
|
|
g.5813delGGTA |
G12/3;IVS2-delGGTA;4IVS2-E3 |
deletion |
splicing defect |
DNA only |
private |
3'-endIVS2 acc spl site, frameshift |
Cross
and Cox,1990 |
|
3 |
R59op |
59 |
TTCCGAG>TTCTGAG |
Arg>Opal |
c.178C>T |
g.5880C>T |
R59X;R59ter |
transition |
nonsense |
DNA only |
0.02 |
CpG dinucleotide, opal stop codon |
Brooks
and Tolan, 1994 |
3 |
I73T |
73 |
GCATCGG>GCACCGG |
Ile>Thr |
c.221T>C |
g.5923T>C |
|
transition |
missense |
Protein expression only |
private |
Protein insoluble |
Esposito,
2004 |
|
3 |
L83C |
83 |
CCT[C]TAC>CCTTAC |
Leu>Leu(fs) |
c.252delC |
g.5954delC |
c.250 delC |
deletion |
frameshift |
DNA only |
private |
|
Gruchota,
2006 |
|
3 |
1123ins12 |
104 |
GGT[]GGG>GGT[GGGGATCGTGGT]GGG |
|
c.314^315ins12 |
g.6016^6017insGGGGATCGTGGT |
‹12E3;V104+GIVV |
insertion |
insertion of 4 amino acids |
DNA only |
private |
|
Pappas
and Tolan, 1997 (#34) |
IVS3 |
K107K12 |
104-107del |
GTG[GTGGGAATCAAG]gtt>GTGgtgggaatcaaagtt |
|
c.324G>A;delGTGGGAATCAAG(312-324) |
g.6026G>A |
g.1133G>A |
transition |
missense leading to splicing defect leading to deletion |
RNA expression analysis |
private |
|
Sanchez,
2002 |
|
IVS3 |
IVS3-1G>A |
|
acagTTA>acaaTTA |
|
|
g.7257G>A |
c.325-1G>C, g.8180G>C,IVS3sas |
transversion |
splicing defect |
DNA only |
private |
|
Esposito,
2004 |
|
4 |
28E4 |
114-151 |
TCC[TCTTGCAGGAACAAACAAAGAAACCACC]ATT>TCCATT |
Pro>Pro(fs) |
c.345-372del28 |
g.7277^7305del |
c.345_72del28 |
deletion |
frameshift |
DNA only |
private |
stop codon at aa 151 |
Santer,
2005 |
|
4 |
Q110Oc |
110 |
GACCAAG>GACTAAG |
Gln>Ochre |
c.331C>T |
g.7264C>T |
|
transition |
nonsense |
DNA only |
private |
|
Esposito,
2004 |
|
4 |
4E4 |
118-120 |
GAAC[AAAC]AAAG>GAACAAAG |
|
c.357delAAAC |
g.7289delAAAC |
4, MD4 |
deletion |
frameshift |
Activity measured in liver biopsy from homozygote |
0.03 |
|
Dazzo
and Tolan, 1990 |
4-5 |
E4-E5 |
|
ccc[tgtŠTCC]AGC>cccAGC |
|
|
g.6594^8239del |
F13/4,5 |
deletion |
large deletion |
DNA only |
private |
1646 bp deletion from IVS3 to part of E5 |
Cross
and Cox,1990 |
|
5 |
C134R |
134 |
CGCTGTG>CGCCGTG |
Cys>Arg |
c.403T>C |
g.8162T>C |
C135R |
transition |
missense |
Protein expressed, partial activity, unstable |
private |
|
Brooks
and Tolan, 1994 |
5 |
W147R |
147 |
AAGTGGC>AAGCGGC |
Trp>Arg |
c.442T>C |
g.8201T>C |
W148R |
transition |
missense |
Protein expressed, partially active |
private |
|
Ali
and Cox, 1995 |
|
5 |
A149P |
149 |
CGTGCTG>CGTCCTG |
Ala>Pro |
c.448G>C |
g.8212G>C |
A150P |
transversion |
missense |
Protein expressed, partial activity, unstable, crystal structure done |
0.57 |
Most common, most well studied |
Cross
et al, 1988 |
|
5 |
Y173Am |
173 |
CTACGCC>CTAGGCC |
Tyr>Amber |
c.522C>G |
g.8281C>G |
Y174X |
transversion |
nonsense |
DNA only |
private |
|
Gruchota,
2006 |
|
5 |
A174D |
174 |
ACGCCAG>ACGACAG |
Ala>Asp |
c.524C>A |
g.8283C>A |
A175D |
transversion |
missense |
Protien expressed, unstable; Activity measured in liver biopsy from
homozygote |
0.13 |
|
Cross
et al, 1990a |
|
5 |
C177R |
177 |
ATCTGTC>ATCCGTC |
Cys>Arg |
c.532T>C |
g.8291T>C |
p.C178R |
transition |
missense |
DNA only |
private |
|
Santer,
2005 |
|
6-7 |
E6-E7 |
|
atc[tcaŠagc]act>atcact |
|
|
g.8989^10457del |
G10/6,7 |
deletion |
large deletion |
DNA only |
private |
1469 bp deletion from IVS5 to IVS7 |
Cross
and Cox,1990 |
|
IVS5 |
IVS5+1G>C |
|
CAGgtgc>CAGctgc |
|
|
g.8300G>C |
G>C,5'intron5;IVS5nt1 |
transversion |
splicing defect |
DNA only |
private |
|
Ali
et al, 1996 |
|
6 |
6E6 |
|
GGA[CTGGTA]CCT>GGACCT |
LeuValdel |
c.547-552delCTGGTA |
g.9149-9154delCTGGTA |
Leu182-Val183del |
deletion |
deletion of 2 amino acids |
DNA only |
private |
|
Santamaria,
1999 |
|
6 |
P184R |
184 |
TACCTAT>TACGTAT |
Pro>Arg |
c.554C>G |
g.9156C>G |
p.P184R |
transversion |
missense |
DNA only |
private |
|
Sanchez-Gutierrez,
2002 |
6 |
Y203Oc |
203 |
GTATGTT>GTAAGTT |
Tyr>Ochre |
c.612T>A |
g.9214T>A |
Y203X;Y203term |
transversion |
nonsense |
DNA only |
private |
ochre stop codon |
Ali
et al, 1993 |
|
6 |
Y203Am |
203 |
GTATGTT>GTAGGTT |
Tyr>Amber |
c.612T>G |
g.9214T>G |
p.Y204X |
transversion |
nonsense |
DNA only |
private |
|
Santer,
2005 |
|
IVS6 |
IVS6-2A>G |
|
ttcagGT>ttcggGT |
|
|
g.10152A>G |
|
transition |
splicing defect |
DNA only |
private |
|
Esposito,
2004 |
|
IVS6 |
IVS6-1G>A |
|
tcagGTC>tcaaGTC |
|
|
g.10153G>A |
G>A,3'intron6;IVS6sas |
transition |
splicing defect |
DNA only |
private |
3'-end of IVS6 acc splice site |
Ali
et. al., 1994b |
|
7 |
V221F |
221 |
CATGTTT>CATTTTT |
Val>Phe |
c.664G>T |
g.10193G>T |
g.10236G>T; p.V222F |
transversion |
missense |
Protein expression only |
private |
Protein insoluble |
Esposito,
2004 |
|
7 |
L228P |
228 |
TGCTAAA>TGCCAAA |
Leu>Pro |
c.686T>C |
g.10215T>C |
g.10258T>C; p.L229P |
transition |
missense |
Protein expression only |
private |
Protein insoluble |
Esposito,
2004 |
|
7 |
C239Op |
239 |
CTGCACC>CTGAACC |
Cys>Opal |
c.720C>A |
g.10249C>A |
M240;C239X;C239ter |
transversion |
nonsense |
Protein expressed |
private |
opal stop codon |
Kajihara
et al, 1990 |
|
7 |
L256P |
256 |
CTCTCCA>CTCCCCA |
Leu>Pro |
c.770T>C |
g.10299T>C |
|
transition |
missense |
Protein expressed, partially active (mild) |
0.01 |
|
Ali
et al, 1994a |
|
IVS7 |
IVS7+2T>A |
|
TGgtaag>TGgaaag |
|
|
g.10333T>A |
c.799+2T>A |
transversion |
splicing defect |
DNA only |
private |
|
Santer,
2005 |
|
8 |
2E8 |
280 |
GCC[AC]TCT>GCCTCT |
Thr>Ser (fs) |
c.841-842delAC |
c.10780-10781delAC |
c.841_842delAC |
deletion |
frameshift |
DNA only |
private |
|
Santer,
2005 |
|
8 |
L283P |
283 |
ACCTCAA>ACCCCAA |
Leu>Pro |
c.851T>C |
g.10790T>C |
p.L284P |
transition |
missense |
DNA only |
private |
|
Santer,
2005 |
|
8 |
L288C |
288 |
AAC[C]TTT>AACTTT |
Leu>Phe (fs) |
c.865delC |
g.10804delC |
L288delC |
deletion |
frameshift |
DNA only |
0.003 |
only in Sicily |
Cross
et al, 1990a |
|
8 |
R303W |
303 |
GGACGGG>GGATGGG |
Arg>Trp |
c.910C>T |
g.10849C>T |
|
transition |
missense |
Protein expressed, decreased activity |
private |
CpG dinucleotide |
Santamaria,
1996 |
|
8 |
R303Q* |
303 |
GACGGGC>GACAGGC |
Arg>Gln |
c.911G>A |
g.10850G>A |
|
transition |
missense |
*Protein expressed, active |
private/poly? |
|
Santamaria,
2000 |
|
IVS8 |
7+1 |
333-334 |
cta[gGCTAAC]TGCCA>ctaTG[G]CCA |
|
[c.1000-1005delGGCTAAC;c.1007^1008insG] |
[g.13875delGGCTAAC;g.13884^13885insG] |
indel |
splicing defect |
RNA splicing analysis confirmation |
private |
3'-end of IVS8 acc splice site and codons333-334 deleted, plus G
insertion at codon 335, expression of RNA showed splicing defect |
Brooks
et al, 1991 |
|
9 |
N334K |
334 |
TAACTGC>TAAGTGC |
Asn>Lys |
c.1005C>G |
g.13882C>G |
|
transversion |
missense |
Protein expressed, partially active |
0.05 |
|
Cross
et al, 1990b |
|
9 |
A337V |
337 |
AGGCGGC>AGGTGGC |
Ala>Val |
c.1013C>T |
g.13890C>T |
|
transition |
missense |
Protein expressed, mild defect, liver biopsy of homozygote showed
decreased activity |
0.01 |
CpG dinucleotide, expression showed alterations in activity |
Rellos
et al, 1999 |
|
9 |
6+5 |
347-349 |
TTC[TTCTGG]GGC>TTC[ACACT]GGC |
SerSerGly>SerHisTrp(fs) |
[c.1043delTTCTGG;c.1043^1044insACACT |
[g.13920delTTCTGG;g.13920^13921insACACT] |
c.1044_1049delTTCTGGinsACACT |
indel |
frameshift |
DNA only |
private |
deletion of 6, insertion of 5, stop codon at 369 |
Santer,
2005 |
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*(Uppercase denotes protein coding sequence,
lowercase denotes non-coding sequence; change is in bold; any codons are
underlined; all are given within a 7-base context) |
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