Design and Analysis of Microarray Experiments and Next Generation Sequencing
SPH BS 830
In this course, students will be presented with the methods for the analysis of gene expression data measured through microarrays. The course will start with a review of the basic biology of gene expression and an overview of microarray technology. The course will then describe the statistical techniques used to compare gene expression across different conditions and it will progress to describe the analysis of more complex experiments designed to identify genes with similar functions and to build models for molecular classification. The statistical techniques described in this course will include general methods for comparing population means, clustering, classification, simple graphical models and Bayesian networks. Methods for computational and biological validation will be discussed.