This course provides students with a fundamental understanding of the epidemiology and control of vaccine-preventable diseases. This will be accomplished by focusing on a different vaccine-preventable disease each week, and using that disease to illustrate epidemiologic principles and methods to measure vaccine safety, efficacy, and impact; and to understand current issues around public acceptability. Emphasis will be placed on study design, sources of bias, and current controversies. The majority of class time will focus on in-class discussions where students will take turns presenting to their peers, and will practice and receive feedback in the critical review and design of epidemiologic studies.