Emergency BU Alert Boston University's Charles River and Medical Center Campuses will be closing today, Monday, January 26, 2015 at 5:00 PM and will be closed all day Tuesday, January 27, 2015. All normal academic and administrative activities (e.g. classes, seminars and meetings) that are scheduled to take place after 5:00 PM on Monday are cancelled. When classes resume, they will resume on the regular class schedule. Whether or how classes are to be made up is at the discretion of the faculty member. For detailed information about the Boston University Medical campus, please go to http://www.bu.edu/ehs/comm Please note: Employees in essential services must report as scheduled. Essential services include, but are not limited to, University Police, Public Safety, Emergency Patient Treatment, Facilities Management and Planning, Environmental Health & Safety, University Dining Services, Mail Services, Student Health Services and the University Switchboard. For the very latest information, please go to http://www.bu.edu/today

Multi-Scale model of ECM mechanics in vascular remodeling

We are developing a multi-scale predictive mechanobiology model of extracellular matrix (ECM) mechanics from a fundamental mechanics perspective coupled with critical biophysical input, and to provide a clinical relevant relationship between biomechanical integrity, biochemical composition stability, and microstructure of the ECM. The research goal will be accomplished through two specific aims that couple modeling and experimental work for a complete model development and validation. Models that can incorporate fundamental physics with patient-specific data are essential for the development of vigorous multidisciplinary research program focusing on cardiovascular mechanics and imaging. The multi-scale mechanobiology model integrating ECM structure and molecular basis that mediate ECM mechanics is critical for future therapeutic intervention in a variety of diseases. Our coupled modeling-experimental approach will establish a foundation to investigate the role of microstructural components in vascular remodeling will establish a foundation to investigate the role of microstructural components in vascular remodeling.