Paul A. Monach, MD, PhD

Dr. Monach serves as the director of the Boston University Vasculitis Center and as a principle investigator in the Vasculitis Clinical Research Consortium (VCRC).  The VCRC is comprised of several vasculitis centers across North America and is dedicated to conducting clinical research in vasculitis.  Dr. Monach sees patients with all forms of vasculitis as well as general rheumatology patients in the outpatient rheumatology clinic.  His specific research interests in vasculitis concern biomarkers and genetics.

Biomarkers are blood tests that provide information useful to physicians making treatment decisions about their patients, i.e., how active is the disease today?  Is it getting better or worse?  Is this patient likely to relapse or to remain in remission long-term?  The current blood tests clinicians use are of limited value, so we are looking for better markers using samples from the VCRC longitudinal studies and clinical trials, with grant support from the National Institute of Health (NIH).

Although vasculitis does not run strongly in families, there are other reasons to suspect that genetics plays a role in susceptibility.  Dr. Monach is currently leading a study to look in vasculitis at genes that have been implicated in other autoimmune diseases such as rheumatoid arthritis, lupus, and Crohn’s disease, with grant support from the Arthritis Foundation.