Maternal-Fetal Medicine, Pediatrics, Molecular Biology – Wang

Professor Alice Wang

Maternal-Fetal Medicine, Pediatrics, Molecular Biology

Options: Volunteer Basis, Independent Funding Available, Potential for UROP Funding, Potential for Work-Study Funding

This research opportunity is ideal for an individual interested in biology or medicine with some basic science research experience, who would like to work in a translational laboratory environment that interfaces directly with patient care. Our lab investigates the process by which the placenta develops the intricate network of maternal and fetal blood vessels required for supplying nutrients to the fetus, and the sequence of angiogenic and growth factors that are required to coordinate this process. This process is dysregulated in conditions such as pre-ecclampsia and ecclampsia, which can be life-threatening for the mother and child. Placental insufficiency can cause intrauterine growth retardation with long-term health consequences for the child. We will be studying placental tissues from normal pregnancie! s, as well as complicated pregnancies affected by these conditions. We will be using biochemistry, molecular biology and immunohistochemistry techniques to examine the regulation of growth factors and cytokines in these conditions. Experience with cell culture, DNA and RNA techniques, PCR/QPCR, ELISA assays, western blotting, and histology would be extremely helpful. There will be opportunities to learn new techniques and potentially to interact with patients, and the work will be done closely with the investigator, who is an attending Neonatal ICU physician at Boston Medical Center.