Ophthamology and Immunology

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Volunteer, UROP, Academic Credit

Overview

Summer research opportunity is available in Masli lab in the Department of Ophthalmology and Immunology Training Program at the School of Medicine. We are looking for a student with a suitable academic background in biomedical sciences (biology, biochemistry, cell biology, molecular biology and chemistry, etc.) to join our ongoing research projects.

Highly motivated and outstanding student interested in pursuing scientific research career in the future will be given preference to begin on a volunteer basis. Based on laboratory skills and progress application for UROP funding will be encouraged for subsequent periods. During summer, students will be expected to commit 32-40 hr/wk and minimum 12 hr/wk during the rest of the academic year. Strong support and training towards career development will be available in the lab.

Ongoing Research:
Masli lab. studies molecular mechanisms underlying regulation of immune responses in the eye. This includes pathogenesis of autoimmune Sjögren’s syndrome that results in the inflammation of the ocular surface related tissues such as cornea, conjunctiva and tear secreting lacrimal glands. Previous research in the laboratory identified Thrombospondin (TSP) as a critical molecule involved in regulation of ocular immune responses. Currently different molecular and genetic mechanisms involving TSP related pathways that contribute to autoimmunity are being investigated. Both in vivo and in vitro studies are conducted. In vivo studies involve use of validated pre-clinical disease models in mice and in vitro studies include primary cultures of epithelial cells derived from the ocular surface and lacrimal gland. Experiments include molecular and cell biology techniques such as PCRs, immunohistochemistry, cell proliferation assays and immunologic assays using flow cytometric analys! is. Another line of investigation addresses analysis of genetic variants of TSP-1 in individuals with ocular pathologies.

Please send an updated CV with a description of your interests, career goals and any previous experience related to ongoing projects in the lab.

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