Molecular Biology and Biophysics – Marintchev
Molecular Biology and Biophysics
Options: Volunteer Basis, Independent Funding Available, Potential for UROP Funding, Potential for Work-Study Funding
We study the mechanisms of protein synthesis (translation) in human, using a combination of biochemical and biophysical methods, including NMR, fluorescence spectroscopy, size exclusion chromatography, and site-directed mutagenesis.
Our work is focused on studying the architecture of the translation complexes, the molecular mechanisms of key steps in the process, and their regulation. The long-term goal is to build a detailed mechanistic and quantitative model of translation, and learn how to rationally manipulate the system for the purposes of cancer therapy and treatment of metabolic disorders.
Available projects involve protein expression and purification, protein-protein and protein-RNA interaction studies, and fluorescence-based high-throughput screening.