Sarkar – Immunology
Immunology of Abdominal Sepsis
Options: Volunteer Basis, Potential for UROP Funding
Lab efforts are directed at understanding the host response to abdominal sepsis and what factors influence survival. Our work involves the use of the cecal-ligation and puncture (CLP) model in mice to replicate surgical pathology and sepsis. We are currently examining the role of mitochondrial DNA in CLP sepsis and regulation of cytokine mRNA stability. Mitochondrial DNA levels correlate with survival in ICU patients with sepsis and trauma. Students will be trained to assist lab personnel in experiments using mice and immune cells harvested from septic animals.