In fact, clinical levels of PTSD frequently do require drugs, especially if the condition is co-morbid for depression, substance abuse, and other conditions. Chronic PTSD or long-standing conditions cause changes to the brain on measurable, observable levels. The ideal treatment for PTSD is usually a combination of medication and some sort of talk therapy. Many women vets have multiple traumas, which increase liklihood of developing PTSD as well as complicating. successful intervention. Some sufferers will have PTSD and require medication for the rest of their lives.