Molecular Epidemiology of Head & Neck Cancer

Funding Source: NCI R01 CA078609-07
PI: Karl Kelsey, MD, MOH, Brown University
Co-Investigators: Michael McClean, ScD, BUSPH; Heather Nelson, PhD, University of Minnesota; Carmen Marsit, PhD, Brown University; Brock Christensen, PhD, Brown University

Funding Source: FAMRI Award# 062555-YSCA
PI: Michael McClean, ScD, BUSPH
Co-Investigators: Karl Kelsey, MD, MOH, Brown University; Carmen Marsit, PhD, Brown University

ebrg_5Head and neck squamous cell carcinoma (HNSCC) is the tenth most common cancer in the US and the sixth most common cancer worldwide. While 75% of HNSCC is attributable to smoking and alcohol consumption, a significant proportion of this disease remains unexplained. Polymorphisms of genes, associated with an increased risk for lung, bladder, and breast cancer, may further alter cancer risk by level of tobacco or alcohol exposure. Tobacco and alcohol by-products are clearly associated with HNSCC, and have been found to induce genetic mutations; therefore, investigation into genetic susceptibility to this disease is warranted. In our population-based multicenter case-control study of HNSCC, we focus on exploring the role of risk factors such as tobacco, alcohol, human papillomavirus, secondhand tobacco smoke, diet, marijuana, and the genetic factors that may modify such relationships.

The first phase of this study included the recruitment of 705 cases and 815 controls in the greater Boston metropolitan area (1999-2003); the second phase began in 2005 and is ongoing, targeting a final sample size of 1300 cases and 1300 controls. Incident cases of HNSCC are identified through seven teaching hospitals located in Boston, Massachusetts. We are currently interviewing and obtaining biologic samples from incident cases and comparable population controls from the greater Boston metropolitan area. We have established a centralized tissue bank, to which we deposit biologic specimens from cases and controls for the purpose of conducting epidemiologic studies of head and neck cancer.

We are also funded to specifically investigate the role of secondhand tobacco smoke (STS) as a risk factor for HNSCC. While it is widely accepted that active smoking and alcohol consumption synergistically increase the risk of HNSCC, the role of STS exposure is considerably less clear and the potential synergistic effect of STS and alcohol on HNSCC risk has yet to be investigated. Utilizing complete histories of STS exposure that have been obtained over time, we are examining STS-related risks at different points in life. Analyzing time-specific exposures may yield insight into the mechanism of action of STS exposure, as well as the mechanism by which alcohol may modify the effect of STS exposure. The collection of vital statistics for cases will also allow us to determine whether the effect of treatment is influenced by STS exposure during treatment.

These findings should lead to an improved characterization of high-risk individuals for whom aggressive preventive measures may be targeted. Our DNA bank and comprehensive epidemiologic approach will also provide an invaluable resource for continuing studies of the molecular and genetic epidemiology of oral cancer.

Publications

  • Liang C, Marsit CJ, Houseman EA, Butler R, Nelson HH, McClean MD, Kelsey KT. 2011. Gene-environment interactions of novel variants associated with head and neck cancer. Head Neck. Published on-line November 2, 2011.
  • Liang C, Marsit CJ, Houseman EA, Butler R, Nelson HH,McClean MD, Kelsey KT. 2011. Gene-environment interactions of novel variants associated with head and neck cancer.Head Neck. Published on-line November 2, 2011.
  • Edefonti V, Hashibe M, Ambrogi F, Parpinel M, Bravi F, Talamini R, Levi F, Yu G, Morgenstern H, Kelsey K, McClean M, Schantz S, Zhang Z, Chuang S, Boffetta P, La Vecchia C, Decarli A. 2011. Nutrient-based dietary patterns and the risk of head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium. Ann Oncol. Published on-line November 28, 2011. PMCID: PMC3387823
  • Li Q, Chuang S, Neto JE, Menezes E, Matos E, Koifman S, Wünsch-Filho V, Fernandez L, Daudt AW, Curado MP, Winn DM, Franceschi S, Herrero R, Castellsague X, Zhang Z, Lazarus P, Muscat J, McClean MD, Kelsey KT, Hayes RB, Purdue MP, Schwartz SM, Chen C, Benhamou S, Olshan AF, Schantz S, Ferro G, Brennan P, Boffetta P, Hashibe M. 2011. Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium. Int J Cancer. Published on-line December 15, 2011. PMCID: PMC3376697
  • Poage GM, Butler RA, Houseman EA, McClean MD, Nelson H, Christensen B, Marsit CJ, Kelsey KT. 2012. Identification of an epigenetic profile classifier derived from the local DNA sequence context that is associated with head and neck cancer survival. Cancer Res. 72(11): 2728-37.
  • Chuang S, Jenab M, Heck JE, Bosetti C, Talamini R, Matsuo K, Castellsague X, Franceschi S, Herrero R, Winn DM, La Vecchia C, Morgenstern H, Zhang Z, Levi F, Dal Maso L, Kelsey K, McClean MD, Vaughan T, Lazarus P, Muscat J, Ramroth H, Chen C, Schwartz S, Eluf-Neto J, Hayes RB, Purdue M, Boccia S, Nicolotti N, Zaridze D, Koifman S, Curado MP, Ahrens W, Benhamou S, Matos E, Lagiou P, Szeszenia-Dabrowska N, Olshan AF, Fernandez L, Menezes A, Agudo A, Daudt AW, Merletti F, Macfarlane GJ, Kjaerheim K, Mates D, Holcatova I, Schantz S, Yu G, Simonato L, Brenner H, Muller H, Conway D, Thomson P, Fabianova E, Znaor A, Rudnai P, Healy C, Ferro G, Brennan P, Boffetta P, Hashibe M. 2012. Diet and the risk of head and neck cancer: A pooled analysis in the INHANCE consortium. Cancer Cause Control. 23: 69–88.
  • Anderson KS, Wong J, D’Souza G, Riemer A, Lorch J, Haddad R, Pai S, Longtine J, McClean MD, LaBaer J, Kelsey KT, Posner M. 2011. Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer. British Journal of Cancer. 104(12): 1896-905. PMCID: PMC3111202
  • Chen D, Truong T, Gaborieau V, Byrnes G, Chabrier A, Chuang S, Olshan AF, Weissler MC, Luo J, Romkes M, Buch S, Nukui T, Franceschi S, Herrero R, Talamini R, Kelsey KT, Christensen B, McClean MD, Lacko M, Manni JJ, Peters WHM, Lubiński J, Trubicka J, Lener M, Muscat JE, Lazarus P, Wei Q, Sturgis EM, Zhang Z, Chang S, Wang R, Schwartz SM, Chen C, Benhamou S, Lagiou P, Holcátová I, Richiardi L, Kjaerheim K, Agudo A, Castellsagué X, Macfarlane TV, Barzan L, Canova C, Thakker NS, Conway DI, Znaor A, Healy CM, Ahrens W, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Fabianova E, Bucur A, Bencko V, Foretova L, Janout V, Curado MP, Koifman S, Menezes A, Wünsch-Filho V, Neto JE, Fernandez L, Boccia S, Hashibe M, Hayes RB, Boffetta P, Brennan P, McKay JD. 2011. A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. Cancer Epidemiol Biomarkers Prev. 20(4): 658-64. PMCID: PMC3070066
  • Lubin JH, Muscat J, Gaudet MM, Olshan AF, Curado MP, Dal Maso L, Wünsch-Filho V, Sturgis EM, Szeszenia-Dabrowska N, Castellsague X, Zhang ZF, Smith E, Fernandez L, Matos E, Franceschi S, Fabianova E, Rudnai P, Purdue MP, Mates D, Wei Q, Herrero R, Kelsey K, Morgenstern H, Shangina O, Koifman S, Lissowska J, Levi F, Daudt AW, Neto JE, Chen C, Lazarus P, Winn D, Schwartz SM, Boffetta P, Brennan P, Menezes A, La Vecchia C, McClean MD, Talamini R, Hayes RB, Hashibe M. 2011. An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies. Cancer Cause Control. 22(9): 1217-31.
  • McKay JD, Truong T, Gaborieau V, ChabrierA, Chuang S, Byrnes G, Zaridze D, Shangina O, Szeszenia Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Holcatova I, Janout V, Foretova L, Lagiou P, Trichopoulos D, Benhamou S, Bouchardy C, Ahrens W, Merletti F, Richiardi L, Talamini R, Barzan L, Kjaerheim K, Macfarlane GJ, Macfarlane TV, Simonato L, Canova C, Agudo A, Castellsagué X, Lowry R, Conway DI, McKinney PA, Healy CM, Toner ME, Znaor A, Curado MP, Koifman S, Menezes A, Wünsch-Filho V, Neto JE, Fernandez L, Boccia S, Cadoni G, Arzani D, Olshen AF, Weissler MC, Funkhouser WK, Luo J, Lubiński J, Trubicka J, Lener M, Oszutowska D, Schwartz SM, Chen C, Fish S, Doody DR, Muscat JE, Lazarus P, Gallagher CJ, Chang S, Greenland S, Zhang Z, Wei Q, Sturgis EM, Wang L, Franceschi S, Herrero R, Kelsey KT, McClean MD, Marsit C, Nelson H, Romkes M, Buch S, Nukui T, Zhong S, Lacko M, Manni JJ, Peters WHM, Hung RJ, McLaughlin J, Vatten L, Njølstad I, Goodman G, Field JK, Liloglou T, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Quirós JR, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Khaw KT, Key T, Bueno-de-Mesquita HB, Peeters PHM, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Välk K, Voodern T, Metspalu A, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Blanche H, Gut I, Galan P, Heath S, Hashibe M, Hayes RB, Boffetta P, Lathrop M, Brennan P. 2011. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. PloS Genet. 7(3): e1001333. PMCID: PMC3060072
  • Poage GM, Houseman EA, Christensen BC, Butler R, Avissar-Whiting M, McClean MD, Waterboer T, Pawlita M, Marsit CJ, Kelsey KT. 2011. Global hypomethylation identifies loci targeted for hypermethylation in head and neck cancer. Clin Cancer Res. 17(11): 3579-89. PMCID: PMC3107873
  • Liang C, Pawlita M, Marsit CJ, Smith JF, Bryan JT, Nelson HH, Waterboer T, McClean MD, Kelsey KT. 2010. Comparison of Antibodies to HPV16 early genes with antibodies to L1 and PCR detection of HPV16 in tumor DNA in Head and Neck Cancer: exposure and survival. American Society of Clinical Oncology. June 4-8. Chicago, IL.
  • Anderson KS, Wong J, Posner MR, Lorch J, McClean MD, Kelsey KT. 2010. Proteome-wide Detection of Antibodies to the HPV16 in Head and Neck Cancer Patient Sera. American Society of Clinical Oncology. June 4-8. Chicago, IL.
  • Galeone C, Tavani A, Claudio P, Turati F, Winn D, Levi F, Morgenstern H, Kelsey K, Dal Maso L, Purdue MP, McClean MD, Talamini R, Hayes RB, Franceschi S, Schantz S, Zhang Z, Ferro G, Chuang S, Boffetta P, La Vecchia C, Hashibe M. 2010. Coffee and tea intake and risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev. 19(7): 1723-36. PMCID: PMC3047460.
  • Christensen BC, Avissar-Whiting M, Ouellet LG, Nelson HH, McClean MD, Marsit CJ, Kelsey KT. 2010. Mature miRNA sequence polymorphism in MIR196A2 is associated with risk and prognosis of head and neck cancer. Clin Cancer Res. 16(14): 3713-20. PMCID: PMC2914465.
  • Lubin JH, Gaudet MM, Olshan AF, Kelsey K, Boffetta P, Brennan P, Castellsague X, Chen C, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, Wünsch-Filho V, Franceschi S, Herrero R, Koifman S, La Vecchia C, Lazarus P, Levi F, Lissowska J, Mates IN, Matos E, McClean MD, Menezes A, Morgenstern H, Muscat J, Neto JE, Purdue MP, Rudnai P, Schwartz SM, Shangina O, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei Q, Winn D, Zhang ZF, Hashibe M, Hayes RB. 2010. Body mass index, cigarette smoking and alcohol consumption and cancers of the oral cavity, pharynx and larynx: modeling odds ratios in pooled case-control data. Am J Epidemiol. 171(12): 1250-61. PMCID: PMC2915496.
  • Poage G, Christensen BC, Houseman EA, McClean MD, Wiencke JK, Posner MR, Clark J, Nelson HH, Marsit CJ, Kelsey KT. 2010. Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted. Plos ONE. 5(3): e9651. PMCID: PMC2836370.
  • Marron M, Boffetta P, Zhang Z, Zaridze D, Wünsch-Filho V, Winn DM, Wei Q, Talamini R, Szeszenia-Dabrowska N, Sturgis EM, Smith E, Schwartz SM, Rudnai P, Purdue M, Olshan AF, Eluf-Neto J, Muscat J, Menezes A, McClean M, Matos E, Mates D, Lissowska J, Levi F, Lazarus P, La Vecchia C, Koifman S, Kelsey KT, Herrero R, Hayes RB, Franceschi S, Fernandez L, Fabianova E, Daudt AW, Dal Maso L, Curado MP, Cadoni G, Chen C, Castellsague X, Boccia S, Benhamou S, Ferro G, Berthiller J, Brennan P, Møller H, Hashibe M. 2010. Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk. Int J Epidemiol. 39(1): 182-96. PMCID: PMC2817090.

Presentations

  • Avissar M, McClean MD, Kelsey KT, Marsit CJ. 2009. MicroRNA Alterations are Associated with Exposures and Clinical Features in Head and Neck Squamous Cell Carcinoma. AACR Annual Meeting. April 18-22. Denver, CO.
  • Poage GM, Christensen BC, Marsit CJ, Houseman EA, Karagas MR, Wrensch MR, Yeh R-F, Nelson HH, Wiemels JL, Zheng S, Posner MR, McClean MD, Wiencke JK, Kelsey KT. 2009. DNA methylation profiles are associated with specific genome-wide copy number alteration profiles in head and neck squamous cell carcinoma. AACR Annual Meeting. April 18-22. Denver, CO.
  • Heck JE, Berthiller J, Vaccarella S, Winn DM, Smith EM, Shangina O, Schwartz SM, Purdue M, Eluf-Neto J, Menezes A, McClean MD, Matos E, Koifman S, Kelsey KT, Herrero R, Hayes RB, Franceschi S, Wünsch-Filho V, Fernandez L, Daudt AW, Curado MP, Chen C, Castellsagué X, Ferro G, Brennan P, Boffetta P, Hashibe M. 2008. Sexual behaviors and the risk of head and neck cancers. IARC-EACR-AACR-ECNIS Symposium, Lyon, France.
  • Hashibe M, Brennan P, Chuang SC, Boccia S, Castellsague X, Chen C, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, Wunsch-Filho V, Fernandez L, Franceschi S, Hayes R, Herrero R, Kelsey K, Koifman S, La Vecchia C, Lazarus P, Levi F, Lence JJ, Mates D, Matos E, Menezes A, McClean MD, Muscat J, Eluf-Neto J, Olshan AF, Purdue M, Rudnai P, Schwartz SM, Smith E, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei QY, Winn DM, Shangina O, Pilarska A, Zhang ZF, Ferro G, Berthiller J, Boffetta P. 2008. Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the INHANCE consortium. AACR Annual Meeting. April 12-16. San Diego, California.
  • Marsit CJ, Christensen BC, Houseman EA, Karagas MR, Wrensch MR, Yeh RF, Nelson HH, Wiemels JL, Zheng S, Posner MR, McClean MD, Wiencke JK, Kelsey KT. 2008. Profiles of DNA methylation in head and neck squamous cell carcinoma: etiology and clinical significance. AACR Annual Meeting. April 12-16. San Diego, California.
  • Marsit CJ, Houseman EA, Kraunz KS, McClean MD, Kelsey KT. 2007. Does DNA hypermethylation and genetic deletion occur as distinct pathways in aerodigestive malignancy? AACR Special Conference Advances and Challenges in Aerodigestive Epithelial Cancer: Genetics, Diagnosis, and Therapy. Charleston, South Carolina.
  • Peters ES, Luckett BG, McClean MD, Kelsey KT. 2006. Food groups, nutrients, and the risk of head and neck cancer. AACR Annual Meeting. November 12-15. Boston, MA.
  • McClean MD, Peter ES, Marsit CJ, Kelsey KT. 2009. Secondhand smoke exposure and alcohol consumption associated with head and neck cancer. Flight Attendants Medical Research Institute. May 11-13. Boston, MA.
  • McClean MD, Peter ES, Marsit CJ, Kelsey KT. 2008. Secondhand smoke and head and neck cancer. Flight Attendants Medical Research Institute. May 12-14. Boston, MA.
  • Peters ES, McClean MD, Liu M, Eisen EA, Mueller N, Kelsey KT. 2005. The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use. Cancer Epidemiol Biomarkers Prev 14(2): 476-82.
  • Kraunz KS, Hsiung D, McClean MD, Liu M, Osanyingbemi J, Nelson HH, et al. 2006. Dietary folate is associated with p16(INK4A) methylation in head and neck squamous cell carcinoma. Int J Cancer. 119(7): p.1553-7.
  • Kraunz KS, McClean MD, Nelson HH, Peters E, Calderon H, Kelsey KT. 2006. Duration but not intensity of alcohol and tobacco exposure predicts p16INK4A homozygous deletion in head and neck squamous cell carcinoma. Cancer Res. 66(8): p.4512-5.
  • Marsit CJ, McClean MD, Furniss CS, Kelsey KT. 2006. Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma. Int J Cancer. 119(8): p.1761-6.
  • Peters ES, McClean MD, Marsit CJ, Lucket B, Kelsey KT. 2006. Glutathione s-transferase polymorphisms and the synergy of alcohol and tobacco in oral, pharyngeal and laryngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 15(11): p.2196-202.
  • Furniss CS, McClean MD, Smith JF, Bryan J, Nelson HH, Peters ES, Posner MR, Clark JR, Eisen EA, Kelsey KT. 2007. Human papillomavirus 16 and head and neck squamous cell carcinoma. Int J Cancer. 120(11): 2386-92.
  • Hsiung DT, Marsit CJ, Houseman EA, Eddy K, Furniss CS, McClean MD, Kelsey KT. 2007. Global DNA methylation level in whole blood as a biomarker of susceptibility for head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 16(1): p.108-14.
  • Applebaum KM, Furniss CS, Zeka A, Posner MR, Smith JF, Bryan J, Eisen EA, Peters ES, McClean MD, Kelsey KT. 2007. Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer. J Natl Cancer Inst. 99(23): p.1801-10.
  • Peters ES, Luckett BG, Applebaum KM, Marsit CJ, McClean MD, Kelsey KT. 2008. Dairy Products, Leanness, and Head and Neck Squamous Cell Carcinoma. Head and Neck. 30(9): 1093-205. PMCID: PMC2683246.
  • Marsit CJ, Posner MR, McClean MD, Kelsey KT. 2008. Hypermethylation of E-cadherin is an independent predictor of improved survival in head and neck squamous cell carcinoma. Cancer. 113(7): 1566-71.
  • Meyer MS, Applebaum KM, Furniss CS, Peters ES, Luckett BG, Smith JF, Bryan J, McClean MD, Kelsey KT. 2008. Human papillomavirus-16 modifies the association between fruit consumption and head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 17(12): 3419-26.
  • Furniss CS, McClean MD, Smith JF, Bryan J, Applebaum KM, Nelson HH, Posner MR, Kelsey KT. 2009. Human papillomavirus 6 seropositivity is associated with risk of head and neck squamous cell carcinoma, independent of tobacco and alcohol use. Ann Oncol. 20(3): 534-41. PMCID: PMC2733070.
  • Hashibe M, Brennan P, Chuang S, Boccia S, Castellsague X, Chen C, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, Wünsch-Filho V, Franceschi S, Hayes RB, Herrero R, Kelsey KT, Koifman S, La Vecchia C, Lazarus P, Levi F, Lence JJ, Mates D, Matos E, Menezes A, McClean MD, Muscat J, Eluf-Neto J, Olshan AF, Purdue M, Rudnai P, Schwartz SM, Smith E, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei Q, Winn DM, Shangina O, Pilarska A, Zhang Z, Ferro G, Berthiller J, Boffetta P. 2009. Interaction between Tobacco and Alcohol Use and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev. 18(2): 541-50.
  • Marsit CJ, Christensen BC, Houseman EA, Karagas MR, Wrensch MR, Yeh R, Nelson HH, Wiemels JL, Zheng S, Posner MR, McClean MD, Wiencke JK, Kelsey KT. 2009. Epigenetic Profiling Reveals Etiologically Distinct Patterns of DNA Methylation in Head and Neck Squamous Cell Carcinoma. Carcinogenesis. 30(3):416-22. PMCID: PMC2650795.
  • Applebaum KM, McClean MD, Nelson HH, Marsit CJ, Christensen BC, Kelsey KT. 2009. Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma. Int J Cancer. 124(11):2690-6. PMCID: PMC2746567.
  • Chen A, Marsit CJ, Christensen BC, Houseman EA, McClean MD, Smith JF, Bryan JT, Posner MR, Nelson HH, Kelsey KT. 2009. Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer. Carcinogenesis. 30(6): 977-81. PMCID: PMC2691140.
  • Christensen BC, Moyer BJ, Avissar M, Ouellet LG, Plaza S, McClean MD, Marsit CJ, Kelsey KT. 2009. A let-7 microRNA binding site polymorphism in the KRAS 3’ UTR is associated with reduced survival in oral cancers. Carcinogenesis. 30(6): 1003-7. PMCID: PMC2691138.
  • Liang C, Marsit CJ, Nelson HH, Christensen BC, Peters ES, McClean MD, Kelsey KT. 2009. A population-based case-control study of marijuana use and head and neck squamous cell carcinoma. Cancer Prevention Research. 2(8): 759-68. PMCID: PMC2812803.
  • Heck JE, Berthiller J, Vaccarella S, Winn DM, Smith EM, Shangina O, Schwartz SM, Purdue M, Eluf-Neto J, Menezes A, McClean MD, Matos E, Koifman S, Kelsey KT, Herrero R, Hayes RB, Franceschi S, Wünsch-Filho V, Fernandez L, Daudt AW, Curado MP, Chen C, Castellsagué X, Ferro G, Brennan P, Boffetta P, Hashibe M. 2010. Sexual Behaviors and Risk of Head and Neck Cancers by Subsite: Pooled analysis from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Int J Epidemiol. 39(1): 166-81. PMCID: PMC2817092.
  • Avissar, M, McClean MD, Kelsey KT, Marsit CJ. 2009. MicroRNA expression in head and neck cancer associates with alcohol consumption and survival. Carcinogenesis. 30(12): 2059-63. PMCID: PMC2792323.