Research Projects

Listed below are selected projects that highlight the DCC’s experience providing leadership and organization in the management of large research projects:

  • The Effect of Diflunisal on Hereditary Amyloidosis 2004 – Ongoing
  • Efficacy of rHuEPO In the Critically Ill Patient 1999 – 2002
  • An Intervention Strategy for Increasing Adherence to CDC Recommendations for the Treatment of AOM 2002-2005
  • Collaborative Home Infant Monitoring Evaluation Study (CHIME) 1994 – Ongoing
  • Children’s HealthWatch 1998 – Ongoing
  • Genetic Modulation of Sickle Cell Disease 2002 – Ongoing
  • An Online Case-Crossover Study of Risk Factors Triggering Acute Gout Flares 2002 – Ongoing
  • Men’s Sexual Health Internet Study 2003 – 2005
  • Alcohol Screening and Online Brief Intervention for College Students: the iHealth Study 2004 – Ongoing
    • Environmental Health
      environmental-healthEnvironmental Health

      Analyzing Patterns in Epidemiologic and Toxicologic Data

      Applying toxicologic approaches to mixtures analysis in environmental epidemiology, both developing methods and applying them in ongoing epidemiology studies. This aim includes the application of mapping methods to analysis of mixtures.

    • Environmental Health
      environmental-healthEnvironmental Health

      Be Well, Work Well Total Worker Health Center

      Assessing the feasibility of an integrated intervention designed to protect and promote health in order to reduce musculoskeletal disorders (MSDs) and improve health behaviors among healthcare workers.

    • Environmental Health
      environmental-healthEnvironmental Health

      Biologic Responses to E-cigarettes

      This laboratory-based study assesses the potential risks, including cancer, of smoking e-cigarettes.

    • Environmental Health
      environmental-healthEnvironmental Health

      Breathe Easy at Home Evaluation

      A web-based referral system to link clinical sites with housing code inspections and enforcement for patients with asthma.

    • Environmental Health
      environmental-healthEnvironmental Health

      Chelsea Collaborative EPA STAR Project

      Investigating new methods to assess cumulative risk to social and environmental stressors in urban populations.

    • Environmental Health
      environmental-healthEnvironmental Health

      Children’s Exposure to SVOC Mixtures Indoors and Associations with Obesity

      This project will test testing the hypothesis that early life exposure to mixtures of SVOCs found in house dust leads to increased odds of obesity in children.

    • Environmental Health
      environmental-healthEnvironmental Health

      Development of AHR Modulators as Triple Negative Breast Cancer Therapeutics

      A preclinical study designed to determine the efficacy and safety of non-toxic therapeutics that target the aryl hydrocarbon receptor (AHR) signaling pathway in the most aggressive forms of human breast cancer.

    • Environmental Health
      environmental-healthEnvironmental Health

      Effects of High Fat Diet and Environmental Obesogen Co-Exposure on Osteoporosis

      Examining how high fat diet and chemical exposure may contribute to osteoporosis.

    • Environmental Health
      environmental-healthEnvironmental Health

      Effects-Based Cumulative Risk Assessment in a Low-Income Community near a Superfund Site

      Develop and apply novel statistical and analytical methods to consider the effects of joint exposure to chemical and non-chemical stressors on multiple health outcomes in New Bedford, MA.

    • Environmental Health
      environmental-healthEnvironmental Health

      Epidemiology of Head and Neck Squamous Cell Carcinoma

      Investigating head and neck squamous cell carcinoma risk and survival focused on exploring the role of HPV infection, epigenetic factors, gene-environment interactions, and occupational exposures.

    • Environmental Health
      environmental-healthEnvironmental Health

      Epidemiology of Immunotoxicant Exposure in Children

      This project evaluates the contribution of PCBs and dioxin-like compounds to decreased immune responses to childhood vaccines in children living on the Faroe Islands.

    • Environmental Health
      environmental-healthEnvironmental Health

      Exposomic Analysis of Mixtures Via Effect Directed Analysis.

      Analyzing mixtures of dust and serum using effect directed analysis to “take apart” mixtures. We then use toxicologic modeling and experiments to determine if the activity of the parts matches the activity of the whole.

    • Environmental Health
      environmental-healthEnvironmental Health

      Health Impacts of Aviation-Related Noise and Air Pollution

      The influence of flight activity on concentrations and comparing outputs with dispersion modeling predictions, health risk assessment models to predict the public health burden of aviation emissions, and epidemiological studies of the cardiovascular effects of aircraft-related noise.

    • Environmental Health
      environmental-healthEnvironmental Health

      Hoarding Intervention in Public Housing: A Pilot Study

      Addressing the challenge of hoarding among public housing residents.

    • Environmental Health
      environmental-healthEnvironmental Health

      Impact of Contractor Utilization on Health and Safety

      This research analyzes the extent to which contracting out extraction of coal from underground mines affects the safety of coal miners.

    • Environmental Health
      environmental-healthEnvironmental Health

      Jet Fuel Exposure and Neurological Effects Among Military Personnel

      A large-scale investigation of the potential neurological health effects associated with exposure to JP8 among US Air Force personnel. JP8 is the most common exposure among US military personnel and affects over 2 million workers worldwide.

    • Environmental Health
      environmental-healthEnvironmental Health

      Longitudinal Investigation of Chronic Kidney Disease Among Central American Workers

      A large-scale epidemiologic investigation of chronic kidney disease in Central American workers, which disproportionately affects younger men.

    • Environmental Health
      environmental-healthEnvironmental Health

      Mathematical Foundations of Descriptive Epidemiology

      A new formulation of descriptive epidemiology using Formal Concept Analysis is being developed. The formal representation uses Galois lattices.

    • Environmental Health
      environmental-healthEnvironmental Health

      Mathematics of Binary Mixtures

      Developing mathematical formulations for combining dose-effect relations in mixtures.

    • Environmental Health
      environmental-healthEnvironmental Health

      Measuring Human Exposure to PBDEs

      Examining how PBDEs enter the indoor environment, how people are exposed, and the extent to which they may be associated with human hormones levels.

    • Environmental Health
      environmental-healthEnvironmental Health

      Modeling the Air Quality and Public Health Benefits of Increased Residential Insulation in the United States

      We are developing models of the energy savings associated with increased residential insulation in the United States, which are linked to combined risk assessment/life cycle assessment models to estimate the public health and greenhouse gas benefits.

    • Environmental Health
      environmental-healthEnvironmental Health

      Modeling the Impact of Building-Wide Energy Retrofits on Environmental Exposures and Occupant Health

      Building, calibrating, and validating a simulation model of the effect of residential environmental exposures on pediatric asthma in low-income multi-family housing.

    • BiostatisticsEnvironmental Health
      biostatisticsenvironmental-healthBiostatistics, Environmental Health

      Mortality Consequences of Non-Fatal Occupational Injuries

      This study uses linked workers’ compensation, Social Security Administration, and National Death Index data to determine the impact of non-fatal workplace injuries and illnesses on all-cause mortality.

    • Environmental Health
      environmental-healthEnvironmental Health

      New Methods for Analyzing Cumulative Risk in Urban Populations

      This study uses qualitative research methods and structural data analysis to characterize environmental burden on an individual and community level in a small but densely populated, ethnically and economically diverse city.

    • Environmental Health
      environmental-healthEnvironmental Health

      Newly Recognized Contributions of Environmental Obesogens to Bone Toxicity

      Osteoporosis does not usually call to mind exposures to chemicals, but our Superfund Research Project has shown that environmental toxicants can cause accumulation of fat in the bone marrow that not only impairs bone building leading to osteoporosis, but also compromises support of immune cell development leading to susceptibility to infection.

    • Environmental Health
      environmental-healthEnvironmental Health

      Novel Genomic Models to Predict Environmental Chemical Carcinogenicity

      This project is developing a platform for predicting the carcinogenicity of thousands of chemicals using a novel, high throughput genomic assay in conjunction with advanced computational analyses.

    • Environmental Health
      environmental-healthEnvironmental Health

      Residential Exposure of Young Children to SVOCs

      Examining residential exposure of children to semivolatile organic compounds (SVOCs) found in many consumer products.

    • Environmental Health
      environmental-healthEnvironmental Health

      Role of Environmental Chemicals in the Development of ALS and Other Neurological Diseases

      This study is designed to investigate the molecular mechanisms through which environmental chemicals increase susceptibility to degenerative neurological diseases including amyotropic lateral sclerosis.

    • Environmental Health
      environmental-healthEnvironmental Health

      Role of the Aryl Hydrocarbon Receptor (AHR) in Thrombosis

      This project evaluates how the aryl hydrocarbon receptor (AHR) controls blood clotting (thrombosis), particularly in patients with chronic kidney disease. A secondary aim is to determine the potential contribution of environmental AHR ligands (activators) to clinically relevant increases in blood clotting.

    • Environmental Health
      environmental-healthEnvironmental Health

      Role of the Aryl Hydrocarbon Receptor in Blood Cell Development

      Evaluating how the aryl hydrocarbon receptor (AHR) and environmental chemicals that activate the AHR affect development of red blood cells and platelets. One subaim is to develop an off-the-shelf protocol for generating unlimited numbers of human red blood cells from induced pluripotent stem cells for transfusions.

    • Environmental Health
      environmental-healthEnvironmental Health

      Role of the Aryl Hydrocarbon Receptor in Mammary Tumorigenesis

      This project is designed to investigate the molecular mechanisms through which ubiquitous environmental chemicals increase breast cancer metastasis and chemotherapy-resistant cancer stem cell generation.