BiographyRyan Ferguson is Director of the Cooperative Studies Program Coordinating Center within the U.S. Department of Veterans Affairs. He is responsible for the planning, execution and analysis of large scale clinical trials within a 140 person research enterprise funded by the Department of Veterans Affairs. The Center (the Massachusetts Veterans Epidemiology Research and Information Center) provides the Department with expertise in large scale clinical trials, epidemiological studies, biobanking and biomedical informatics. Among his current portfolio is the Point of Care Research Program. This national project uses innovative health informatics to embed clinical research in the clinical care system in order to create a 'learning healthcare system'. The majority of clinical trials conducted by the program are Phase III-IV IND/IDE regulated trials. The Center develops investigator-initiated research letters of intent into full proposals. The process involves a series of planning meetings with national and international content experts and culminates with a mature protocol including study design, data collection forms, statistical analysis plans and monitoring procedures. Protocols are then defended through a peer-reviewed process. After approval, the Center executes the trials using recruitment sites at clinical centers across the country (VA and non-VA) . International collaborations with Canada and Australia are currently being executed. The studies range from hundreds to thousands of participants at up to 40 recruitment sites and run from 2 - 7 years in duration. The clinical trials have been developed in many content areas including pulmonary disease, rheumatoid arthritis, schizophrenia, alcoholism, diabetes, cardiovascular disease, post-traumatic stress disorder and oncology. The Center has published clinical trial results in prestigious medical journals and has presented results at national and international medical conferences. During his tenure as the Center Director the Center became ISO 9001 registered as a clinical trial coordinating center, and risk-based monitoring and other innovative operational changes were implemented. In addition to his center leadership duties, Dr. Ferguson is a co-Principal Investigator for the VA Point of Care Program, a pragmatic trial program that embeds clinical operations into the VA EMR. He is also the Principal Investigator responsible independent epidemiologic research in chronic diseases in the veteran population.
- Boston University School of Public Health, DSc
- Boston University School of Public Health, MPH
- University of Massachusetts - Amherst, BSc
- Published on 2/29/2016
Fiore LD, Brophy MT, Turek S, Kudesia V, Ramnath N, Shannon C, Ferguson R, Pyarajan S, Fiore MA, Hornberger J, Lavori P. The VA Point-of-Care Precision Oncology Program: Balancing Access with Rapid Learning in Molecular Cancer Medicine. Biomark Cancer. 2016; 8:9-16. PMID: 26949343.
- Published on 1/21/2015
Minnings K, Kerns E, Fiore M, Fiore M, Parekh RS, DuBois J, Isbell TS, Ferguson R, Fiore L. Chronic kidney disease prevalence in Rivas, Nicaragua: use of a field device for creatinine measurement. Clin Biochem. 2015 Apr; 48(6):456-8. PMID: 25617662.
- Published on 2/24/2012
D'Avolio L, Ferguson R, Goryachev S, Woods P, Sabin T, O'Neil J, Conrad C, Gillon J, Escalera J, Brophy M, Lavori P, Fiore L. Implementation of the Department of Veterans Affairs' first point-of-care clinical trial. J Am Med Inform Assoc. 2012 Jun; 19(e1):e170-6. PMID: 22366293.
- Published on 4/1/2011
Fiore LD, Brophy M, Ferguson RE, D'Avolio L, Hermos JA, Lew RA, Doros G, Conrad CH, O'Neil JA, Sabin TP, Kaufman J, Swartz SL, Lawler E, Liang MH, Gaziano JM, Lavori PW. A point-of-care clinical trial comparing insulin administered using a sliding scale versus a weight-based regimen. Clin Trials. 2011 Apr; 8(2):183-95. PMID: 21478329.
- Published on 12/1/2010
Huang GD, Ferguson RE, Peduzzi PN, O'Leary TJ. Scientific and organizational collaboration in comparative effectiveness research: the VA cooperative studies program model. Am J Med. 2010 Dec; 123(12 Suppl 1):e24-31. PMID: 21184863.