Lawrence Mwananyanda
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Lawrence Mwananyanda, MD

Adjunct Research Assistant Professor, Global Health - Boston University School of Public Health

(617) 414-1268
lawyanda@bu.edu
Lusaka, Zambia
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Biography

Dr. Lawrence Mwananyanda is a clinician/scientist with a wealth of experience in conducting medical and public health research. He has been Principal Investigator or Co-PI on multiple research project. His portfolio includes being the Director of the HIV Vaccines Trials Unit at the Botswana Harvard Partnership where he and colleagues worked on the first Phase 1 HIV vaccine trials to be conducted in Africa. His interest with HIV vaccines research continued with his stint at the Emory University under the Zambia HIV Research Project where they studied conformational changes of the HIV at infection in a cohort of discordant couples to aid in design of next generation HIV trial vaccines.

With colleagues at Boston University, Dr. Mwananyanda’s focus has been research on child survival. Ongoing research include the Zambia Pertussis RSV Infant Mortality Estimation Study (ZPRIME) Southern Africa Mother Infant Pertussis Study – Nasopharyngeal Carriage (SAMIPS-NPC), Zambia Infant Cohort Study (ZICS) whose overall goal is to determine if HIV-exposed but uninfected infants (HEU) infants born to HIV-infected mothers on antiretroviral therapy have increased morbidity and mortality, and to correlate maternal Immune Activation (with infant clinical outcome, and immune dysregulation as a potential mechanism for the poor HEU outcome. All these studies are based in Lusaka, Zambia. Dr. Mwananyanda is also the Zambia Site Director for the Harvard-Boston University-Northwestern University-New Mexico Fogarty Global Health program.

Education

  • Jagiellonian University, MD Field of Study: Medicine
  • University of Alabama at Birmingham, MPH Field of Study: Epidemiology
  • Jagiellonian University, BSc Field of Study: Biology

Websites

Publications

  • Published on 3/12/2024

    Sheppard RJ, Watson OJ, Pieciak R, Lungu J, Kwenda G, Moyo C, Chanda SL, Barnsley G, Brazeau NF, Gerard-Ursin ICG, Olivera Mesa D, Whittaker C, Gregson S, Okell LC, Ghani AC, MacLeod WB, Del Fava E, Melegaro A, Hines JZ, Mulenga LB, Walker PGT, Mwananyanda L, Gill CJ. Author Correction: Using mortuary and burial data to place COVID-19 in Lusaka, Zambia within a global context. Nat Commun. 2024 Mar 12; 15(1):2213. PMID: 38472189.

     Read At: PubMed
  • Published on 3/11/2024

    Gallagher KE, Awori JO, Knoll MD, Rhodes J, Higdon MM, Hammitt LL, Prosperi C, Baggett HC, Brooks WA, Fancourt N, Feikin DR, Howie SRC, Kotloff KL, Tapia MD, Levine OS, Madhi SA, Murdoch DR, O'Brien KL, Thea DM, Baillie VL, Ebruke BE, Kamau A, Moore DP, Mwananyanda L, Olutunde EO, Seidenberg P, Sow SO, Thamthitiwat S, Scott JAG. Factors predicting mortality in hospitalised HIV-negative children with lower-chest-wall indrawing pneumonia and implications for management. PLoS One. 2024; 19(3):e0297159. PMID: 38466696.

     Read At: PubMed
  • Published on 7/13/2023

    McClintock J, Odom-Mabey AR, Kebere N, Ismail A, Mwananyanda L, Gill CJ, MacLeod WB, Pieciak RC, Lapidot R, Johnson WE. Postmortem Nasopharyngeal Microbiome Analysis of Zambian Infants With and Without Respiratory Syncytial Virus Disease: A Nested Case Control Study. Pediatr Infect Dis J. 2023 Aug 01; 42(8):637-643. PMID: 37093853.

     Read At: PubMed
  • Published on 6/29/2023

    Sheppard RJ, Watson OJ, Pieciak R, Lungu J, Kwenda G, Moyo C, Chanda SL, Barnsley G, Brazeau NF, Gerard-Ursin ICG, Olivera Mesa D, Whittaker C, Gregson S, Okell LC, Ghani AC, MacLeod WB, Del Fava E, Melegaro A, Hines JZ, Mulenga LB, Walker PGT, Mwananyanda L, Gill CJ. Using mortuary and burial data to place COVID-19 in Lusaka, Zambia within a global context. Nat Commun. 2023 Jun 29; 14(1):3840. PMID: 37380650.

     Read At: PubMed
  • Published on 6/26/2023

    Egbe FN, Cowden C, Mwananyanda L, Pierre C, Mwansa J, Lukwesa Musyani C, Lyondo A, Kapasa ML, Machona S, Chilufya MM, Munanjala G, Coffin SE, Hamer DH, Bates MA. Etiology of Bacterial Sepsis and Isolate Resistance Patterns in Hospitalized Neonates in Zambia. Pediatr Infect Dis J. 2023 Oct 01; 42(10):921-926. PMID: 37364138.

     Read At: PubMed
  • Published on 5/18/2023

    Osei-Poku GK, Mwananyanda L, Elliott PA, MacLeod WB, Somwe SW, Pieciak RC, Hamapa A, Gill CJ. Qualitative assessment of infant sleep practices and other risk factors of sudden infant death syndrome (SIDS) among mothers in Lusaka, Zambia. BMC Pediatr. 2023 May 18; 23(1):245. PMID: 37202764.

     Read At: PubMed
  • Published on 5/11/2023

    Gunning CE, Rohani P, Mwananyanda L, Kwenda G, Mupila Z, Gill CJ. Young Zambian infants with symptomatic RSV and pertussis infections are frequently prescribed inappropriate antibiotics: a retrospective analysis. PeerJ. 2023; 11:e15175. PMID: 37193027.

     Read At: PubMed
  • Published on 1/18/2023

    Sialubanje C, Kaiser JL, Ngoma T, Mwananyanda L, Fong RM, Hamer DH, Scott NA. Postnatal care services in rural Zambia: a qualitative exploration of user, provider, and community perspectives on quality of care. BMC Pregnancy Childbirth. 2023 Jan 18; 23(1):39. PMID: 36653751.

     Read At: PubMed
  • Published on 12/6/2022

    Gill CJ, Mwananyanda L, MacLeod WB, Kwenda G, Pieciak RC, Etter L, Bridges D, Chikoti C, Chirwa S, Chimoga C, Forman L, Katowa B, Lapidot R, Lungu J, Matoba J, Mwinga G, Mubemba B, Mupila Z, Muleya W, Mwenda M, Ngoma B, Nakazwe R, Nzara D, Pawlak N, Pemba L, Saasa N, Simulundu E, Yankonde B, Thea DM. What is the prevalence of COVID-19 detection by PCR among deceased individuals in Lusaka, Zambia? A postmortem surveillance study. BMJ Open. 2022 Dec 06; 12(12):e066763. PMID: 36600354.

     Read At: PubMed
  • Published on 11/15/2022

    Osei-Poku GK, Mwananyanda L, Elliot PA, MacLeod WB, Somwe SW, Pieciak RC, Gill CJ. Assessing infant sleep practices and other risk factors of SIDS in Zambia: a cross-sectional survey of mothers in Lusaka, Zambia. BMC Pediatr. 2022 Nov 15; 22(1):660. PMID: 36380292.

     Read At: PubMed

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