Interaction Between Low Birthweight and Obesity-associated Polymorphisms in Relation to Adult BMI in U.S. Black Women

Obesity has reached epidemic proportions throughout the world. Obesity is a contributing cause to increased risk of many conditions, including cardiovascular disease. Although a westernized lifestyle is the major cause driving the obesity epidemic, some individuals with the same lifestyle are more prone than others to develop obesity.

The major problem addressed in the present study, part of the broader Black Women’s Health Study (BWHS), is why some individuals are more prone than others to become obese under the same conditions (for example, lack of physical activity and high-caloric diets). In particular, in the present study it is proposed that susceptibility to become obese may be in part determined by early-life events such as low weight at birth and variation in certain genes that are expressed in the central nervous system.

Edward Ruiz-Narváez, Sc.D., Principal Investigator
Slone Epidemiology Center

Source of Funding:

American Heart Association, National Center

Study Period:

2011 to 2015