Gene Polymorphisms in Relation to Cancer in Black Women

Gene PolymorphismsDuring the first period of the study, cheek cell samples were obtained from ~27,000 Black Women’s Health Study (BWHS) participants by the mouthwash-swish methods.  Samples from ~900 breast cancer cases and matched controls were genotyped in fine-mapping of the loci identified as associated with breast cancer risk in genome-wide association studies of European and Asian ancestry women.   In addition, replication genotyping of the top 60 SNPs from the first GWAS in African American women was carried out.   Under continuation funding, we will genotype the top 1500 SNPs from the collaborative GWAS in BWHS breast cancer cases and controls and carry out a meta-analysis of results with results of the GWAS.  We will also carry out targeted sequencing of two loci of interest.

Investigators and Study Staff


Julie R. Palmer, Sc.D., Principal Investigator
Slone Epidemiology Center

Lynn Rosenberg, Sc.D., Co-Investigator
Slone Epidemiology Center

Edward Ruiz-Narváez, Sc.D., Genetic Epidemiologist
Slone Epidemiology Center

L. Adrienne Cupples, Sc.D.,  Biostatistician
Boston University School of Public Health

Study Staff:

Stephen Haddad, Data Analyst

Study Details

Source of Funding:

National Cancer Institute

Study Period:

2003 to 2013

Contact Information

Email Julie R. Palmer, Sc.D., at