Nested Case-Control Study of Maternal Herpes Viruses in Relation to Gastroschisis

Gastroschisis is a congenital abdominal wall defect where the bowel and other organs are outside of the body at birth and it carries substantial surgical and medical consequences. This study will examine 4 infectious agents with patterns of occurrence that match the epidemiologic profile of gastroschisis: Epstein-Barr virus, herpes simplex virus 2, cytomegalovirus, and Chlamydia trachomatis, using data from the Finnish Maternity Cohort. First trimester serum samples will be assayed for markers of these infections among mothers of gastroschisis cases and a sample of control subjects.

Martha M. Werler, Sc.D., Principal Investigator
Slone Epidemiology Center

Helja-Marja Surcel, Ph.D., Co-Investigator
Professor and Head of Laboratory, University of Oulu, Finland

Klaus Hedman, M.D., Consultant
Professor of Clinical Virology, University of Helsinki, Finland

Source of Funding:

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Study Period:

April 1, 2013 to March 31, 2015