Case-Control Study of Colon and Rectal Cancer


To determine whether the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk of colon and rectal cancer.


Incident case of colon and rectal cancer in women and men below the age of 70 years were ascertained through a network of collaborating hospitals in Massachusetts . For each case, a control matched on age, gender, and precinct was selected from a town list. Information was obtained through telephone interviews. Discharge summaries were obtained for the cases of cancer.


Regular recent NSAID use was associated with a reduced risk of colorectal cancer.

Lynn Rosenberg, Sc.D., Principal Investigator
Carol Louik, Sc.D., Co-Investigator

Source of Funding:

National Cancer Institute

Study Period:

April 1992 to March 1995

  • Coogan PF, Rosenberg L, Louik C, Zauber AG, Stolley PD, Strom BL, Shapiro S. NSAIDs and risk of colorectal cancer according to presence or absence of family history of the disease. Cancer Causes Control 2000;11:249-55.
  • Prihartono N, Palmer JR, Louik C, Shapiro S, Rosenberg L. A case-control study of use of postmenopausal female hormone supplements in relation to the risk of large bowel cancer. Cancer Epidemiol Biomarkers Prev 2000;9:443-7.
  • Rosenberg L, Louik C, Shapiro S. Nonsteroidal anti-inflammatory drug use and reduced risk of large bowel carcinoma. Cancer 1998;82:2326-33.