David W. Kaufman, Sc.D.

David KaufmanAssociate Director
Slone Epidemiology Center

Professor of Epidemiology
Boston University Schools of Public Health

dwk@bu.edu

Education:

M.S., 1979, Harvard School of Public Health
Sc.D., 1983, Harvard School of Public Health

Research Interests:

David Kaufman joined the newly created Drug Epidemiology Unit (now the Slone Epidemiology Center ) in 1975, as a Research Associate. His early career as an epidemiologist at the DEU was primarily spent in studies of drugs and other factors in relation to cancer, heart disease, and various other conditions. Together with Drs. Slone, Shapiro, and Lynn Rosenberg, he participated in the development of Case-Control Surveillance. In the 1980s, Dr. Kaufman was co-investigator of the International Agranulocytosis and Aplastic Anemia Study, a pioneering effort in the evaluation of these extremely rare but often drug-induced blood dyscrasias that was conducted in seven countries with several hundred cases enrolled. He has directed studies of aplastic anemia in Thailand and the United States. The Thai study is the largest epidemiological investigation of aplastic anemia that has been conducted, with over 500 cases and 2200 controls. Dr. Kaufman pursued his interest in rare drug induced diseases as principal investigator of an international study of Stevens-Johnson syndrome and toxic epidermal necrolysis conducted in four countries in Europe, and a study of anaphylaxis conducted in Spain, Hungary, India, and Sweden. Other major activities have included an international study of analgesics in relation to upper gastrointestinal bleeding and a multicenter study of end stage renal disease patients in three regions of the U.S. More recently, Dr. Kaufman worked closely with Allen Mitchell in the implementation of the Slone Survey, a U.S. population-based survey of medication use. He was principal investigator of a study that documented an inverse relationship between Oxalobacter formigenes, an oxalate metabolizing bacterium found in the colons of about 40% of the normal population, and calcium oxalate kidney stones. He also directed the Patient Registries at Slone: Myeloma and MDS, a nationwide effort that followed patients with the two diseases through the course of their illness. Currently Dr. Kaufman is co-principal investigator for a large scale behavioral surveillance program of acetaminophen users and is involved in other postmarketing surveillance activities. He was Assistant Director of the Slone Epidemiology Unit from 1986 to 1997, and has been Associate Director since 1998.

Recent Publications

The following are Dr. Kaufman’s 25 most recent publications:

  • Goodin DS, Corwin MJ, Kaufman DW, Golub H, Reshef S, Rametta MJ, Knappertz V, Cutter G, Pleimes D. Causes of death among commercially insured multiple sclerosis patients in the United States. PLoS ONE (in press).
  • Kaufman DW, Reshef S, Golub HL, Peucker M, Corwin MJ, Goodin DS, Knappertz V, Pleimes D, Cutter G. Survival in commercially insured multiple sclerosis patients and comparator subjects in the U.S. Mult Scler Relat Disord 2014;3:364-71. doi: 10.1016/j.msard.2013.12.003.
  • Kaufman DW. Field studies. In: Strom BL, Kimmel SE, Hennessy S, eds. Textbook of pharmacoepidemiology. 2nd ed. West Sussex, UK: Wiley-Blackwell, 2013:178-89.
  • Kaufman DW, Kelly JP, Rohay JM, Malone MK, Weinstein RB, Shiffman S. Prevalence and correlates of exceeding the labeled maximum dose of acetaminophen among adults in a U.S.-based internet survey. Pharmacoepidemiol Drug Saf 2012;21:1280-88. doi: 10.1002/pds.3350.
  • Kaufman DW. Field studies. In: Strom BL, Kimmel SE, Hennessy S, eds. Pharmacoepidemiology. 5th ed. West Sussex, UK: Wiley-Blackwell, 2012:347-63.
  • Hall S, Chiu G, Kaufman DW, Wittert G, Link C, McKinlay JB. Commonly-used antihypertensives and lower urinary tract symptoms: results from the Boston Area Community Health (BACH) Survey. Br J Urol 2012;109(11):1676-84. doi: 10.1111/j.1464-410X.2011.10593.x.
  • Kelly JP, Curhan GC, Cave DR, Anderson TE, Kaufman DW. Factors related to colonization with Oxalobacter formigenes in U.S. adults. J Endourol 2011;25(4):673-9. doi: 10.1089=end.2010.0462. PMCID: PMC3071521.
  • Vernacchio L, Kelly JP, Kaufman DW, Mitchell AA. Vitamin, fluoride, and iron use among US children younger than 12 years of age: results from the Slone Survey 1998-2007. J Am Diet Assoc 2011;111(2):285-9. doi: 10.1016/j.jada.2010.10.046.
  • Kelly JP, Kaufman DW, Dunant A, Mockenhaupt M, Roujeau JC. Response to “Seasonal variation of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with trimethoprim-sulfamethoxazole” [letter to the editor]. J Am Acad Dermatol 2011;64(6):1193-4. doi: 10.1016/j.jaad.2009.08.036.
  • Abel GA, Van Bennekom CM, Stone RM, Anderson TE, Kaufman DW. Classification of the myelodysplastic syndrome in a national registry of recently diagnosed patients. Leuk Res 2010;34(7):939-41. doi: 10.1016/j.leukres.2009.12.012.
  • Hall SA, Chiu GR, Kaufman DW, Kelly JP, Link CL, Kupelian V, McKinlay JB. General exposures to prescription medications by race/ethnicity in a population-based sample: results from the Boston Area Community Health Survey. Pharmacoepidemiol Drug Saf 2010;19(4):384-92. doi: 10.1002/pds.1920.
  • Vernacchio L, Kelly JP, Kaufman DW, Mitchell AA.  Medication use among U.S. children <12 years of age: results from the Slone Survey 1998 – 2007.  Pediatrics 2009;124(2):446-54.
  • Kaufman DW, Anderson T, Issaragrisil S. Risk factors for leukemia in Thailand. Ann Hematol 2009;88(11):1079-88.
  • Wantanabe H, Kamijima Y, Sato T, Kaufman DW, Kubota K.  Ex-drinking may be a surrogate for unmeasured risk factors for upper gastrointestinal bleeding: reappraisal and an additional survey of subjects from a case-control study in Japan. Eur J Epidemiol 2009;24(3):143-7.
  • Willy M, Kelly JP, Nourjah P, Kaufman DK, Budnitz D, Staffa J. Emergency department visits attributed to selected analgesics, United States, 2004-2005. Pharmacoepidemiol Drug Saf 2009;18(3):188-95.
  • Levi N, Bastuji-Garin S, Mockenhaupt M, Rojeau J-C, Flahault A, Kelly JP, Martin E, Kaufman DW, Maison P. Medications as risk factors of Stevens-Johnson syndrome and toxic epidermal necrolysis in children: a pooled analysis. Pediatrics 2009;123(2):e297-304.
  • Vernacchio L, Kelly JP, Kaufman DW, Mitchell AA.  Pseudoephedrine use among U.S. children 1999-2006: results from the Slone Survey.  Pediatrics 2008;122(6):1299-304.
  • Kaufman DW. Design and conduct of surveys on dietary supplement use: factors to consider. In: Greenwood MRC, Oria M, eds. Dietary supplement use by military personnel. Washington, DC: The National Academics Press, 2008:B32-9.
  • Kelly JP, Cook SF, Kaufman DW, Anderson TE, Rosenberg L, Mitchell AA.  Prevalence and characteristics of opioid use in the U.S. adult population. Pain 2008;138(3):507-13.
  • Vernacchio L, Kelly JP, Kaufman DW, Mitchell AA.  Cough and cold medication use by U.S. children, 1999-2006: results from the Slone Survey. Pediatrics 2008;122(2):e323-9.
  • Kaufman DW.  Interpretation of associations in pharmacoepidemiology.  Semin Hematol 2008;45(3):181-8.
  • Young NS, Kaufman DW.  The epidemiology of acquired aplastic anemia.  Haematologica 2008;93:489-92.
  • Kaufman DW, Kelly JP, Curhan GC, Anderson TE, Dretler SP, Preminger GM, Cave DR.  Oxalobacter formigenes may reduce the risk of calcium oxalate kidney stones.  J Am Soc Nephrol 2008;19(6):1197-203.
  • Adams SM, Howe HL, Kaufman DW, Kim S, Lappin DR, Yood MU. Principles of registry ethics, data ownership, and privacy. In: Gliklich RE, Dreyer NA, eds. Registries for evaluating patient outcomes: a user’s guide. Rockville, MD: Agency for Healthcare Research and Quality, 2007:87-118.
  • Henrich WL, Clark RL, Kelly JP, Buckalew VM, Fenves A, Finn WF, Shapiro JI, Kimmel PL, Eggers P, Agodoa LE, Porter GA, Shapiro S, Toto R, Anderson T, Cupples LA, Kaufman DW.  Non-contrasted computerized tomography and analgesic-related kidney disease: report of the National Analgesic Nephropathy Study.  J Am Soc Nephrol 2006;17:1472-80.