The Boston University Fever Study

A randomized controlled clinical trial of the short-term safety of ibuprofen for children involving over 83,000 subjects randomized to ibuprofen or acetaminophen for treatment of an acute febrile illness.

Publication List:

• Lesko SM, Louik C, Vezina RM, Mitchell AA . Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics 2002;109(2):e20.

• Lesko SM, Mitchell AA. The safety of acetaminophen and ibuprofen among children younger than two years old. Pediatrics 1999;104:e39.

• Lesko SM, Mitchell AA. Renal function after short-term ibuprofen use in infants and children. Pediatrics 1997;100:954-7.

• Lesko SM, Mitchell AA . An assessment of the safety of pediatric ibuprofen: a practitioner-based randomized cl ini cal trial. JAMA 1995;273:929-33.

• Mitchell AA, Lesko SM. When a randomized controlled trial is needed to assess drug safety. The case of paediatric ibuprofen. Drug Safety 1995;13:15-24.

Invasive Group A Streptococcal Infection and NSAID Use in Children with Varicella

A case-control study of the risk of invasive group A streptococcal infections in children with primary varicella treated with nonsteroidal anti-inflammatory medications.

Publication List:

• Lesko SM, O’Brien KL, Schwartz B, Vezina R, Mitchell AA. Invasive group A streptococcal infection and nonsteroidal anti-inflammatory drug use among children with primary varicella. Pediatrics 2001;107:1108-15.

National Pediatric Diarrhea Surveillance Study

A prospective cohort study of diarrhea in over 600 children, funded by the U.S. Department of Agriculture and performed in collaboration with colleagues at Tufts University. Follow-up is complete and manuscript preparation is ongoing at the current time.

Publication List:

• Vernacchio L, Vezina RM, Mitchell AA, Lesko SM, Plaut AG, Acheson DWK. Diarrhea in American infants and young children in the community setting: incidence, clinical presentation and microbiology.  Pediatr Infect Dis J 2006;25(1):2-7.

• Vernacchio L, Vezina RM, Mitchell AA, Lesko SM, Plaut AG, Acheson DWK. Characteristics of persistent diarrhea in a community-based cohort of young U.S. children.  J Pediatr Gastroenterol Nutr 2006 Jul;43 (1):52-58.

• Vernacchio L, Vezina RM, Mitchell AA, Lesko SM, Plaut AG, Acheson DWK. Epidemiology and clinical presentation of community-acquired diarrhea in infants and young children in the United States: the National Pediatric Diarrhea Surveillance Study [Abstract]. Pediatric Academic Societies’ Annual Meeting, May 2004.

• Vernacchio L, Vezina RM, Mitchell AA, Lesko SM, Plaut AG, Acheson DWK. Microbiology of community-acquired diarrhea in infants and young children in the United States: the National Pediatric Diarrhea Surveillance Study [Abstract]. Pediatric Academic Societies’ Annual Meeting, May 2004.

Xylitol for the Prevention of Acute Otitis Media

A pilot randomized controlled clinical trial funded by the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health. The study is designed to evaluate critical issues in the use of xylitol to prevent acute otitis media in young children in preparation for a large definitive trial. This study is ongoing at the current time.

Publication List:

• Vernacchio L, Vezina RM, Mitchell AA. Tolerability of oral xylitol solution in young children: Implications for otitis media prophylaxis. Int J Pediatr Otorhinolaryngol 2007;71(1):89-94.

• Vernacchio L, Vezina RM, Ozonoff AA, Mitchell AA.  Validity of parental reporting of recent episodes of acute otitis media: A Slone Center Office-based (SCOR) Network study.  J Am Board Fam Med 2007;20:160-163.

• Vernacchio L, Vezina RM, Mitchell AA.  Management of acute otitis media by primary care physicians: Trends since the release of the 2004 American Academy of Pediatrics/American Academy of Family Physicians Clinical Practice Guideline.  Pediatrics 2007;120(2);281-87.

• Vernacchio L, Mitchell AA.  Xylitol to prevent acute otitis media.  [Letter to the Editor]  Pediatr Infect Dis J 2007;26(9):863-4.