Uterine fibroids are the primary indication for hysterectomy in the US and their incidence is 2-3 times higher in black women than white women.  None of the environmental risk factors identified in previous studies explains the difference in rates.  We will compare genes of Black Women's Health Study (BWHS) participants with and without fibroids in an attempt to identify genes potentially involved in the etiology of fibroids. A total of 2500 cases (fibroids) and 2500 controls (without fibroids) will be studied. Differences will also be examined according to age at onset and disease severity. The DNA for these analyses will be obtained from saliva samples that have been provided by BWHS participants.

Investigators:

Lauren Wise, Sc.D., Principal Investigator
Slone Epidemiology Center

David Reich, Ph.D., Co-investigator
Broad Institute of Harvard and MIT

Lynn Rosenberg, Sc.D., Co-Investigator
Slone Epidemiology Center

Fibroids Consultant:

Elizabeth A. Stewart, M.D.
Mayo Clinic

Study Staff:

Paul Muller, M.S.

Rose Radin, M.P.H.

Source of Funding:

National Institute of Child Health and Human Development

Study Period:

2009 - present