Projects

Genome-Wide Association Studies

• Genetic Modifiers of the Severity of Sickle Cell Anemia Identified Through a Genome-Wide Association Study 
  • Supplementary Material:
    • Supplemental table 1
    • Supplemental table 2
• Method to analyse pooling-based genome wide association studies

Genetic Modulation of Sickle Cell Anemia Phenotypes

• AVN
• Stroke
• Priapism (genetic data)

Genetic Modulation of Fetal Hemoglobin (HbF)

• Article: Sebastiani et al., Bayesian Beta regression model used to discover new genetic modulators of HbF [ American Journal of Hematology]

Predicting Severity of Sickle Cell Disease

• Article: Sebastiani et al. A network model to predict the risk of death in sickle cell disease [Blood 2007]
• On line calculator of severity of sickle cell disease [Disclaimer]
• Supplementary Material:
  • Document D1: analysis.
  • Document D2: conditional probability tables that define the network.
  • The Bayesian network that can be used with Bayesware Discoverer
  • Contact: Paola Sebastiani sebas@bu.edu

 Gene Expression

• HPAEC: Differential Gene Expression in Pulmonary Artery Endothelial Cells Exposed to Sickle Cell Plasma

updated 10.14.09