Peter M. Kang, MD

Peter M. Kang, MD

Title
Adjunct Assistant Professor, Department of Health Sciences, Boston University
Programs in Human Physiology
Associate Professor of Medicine, Harvard Medical School
Director, Cardiovascular Physiology Core, Beth Israel Deaconess Medical Center
Email
pkang@bidmc.harvard.edu
Phone
(617) 735-4290
Education
B.A. (Biochemistry), University of California at Berkeley
M.D. (Medicine), George Washington University School of Medicine

Scholarly Interests

We study the molecular mechanisms involved in cardiac apoptosis, and the contribution of cardiac apoptosis to the progression to heart failure. Particularly, we are characterizing the role of caspase-independent apoptosis in heart using both in vitro and in vivo models, and examining several strategies to inhibit apoptosis in heart. Furthermore, we are studying the mechanism and the therapeutic potential of activated vitamin D in treatment of cardiac hypertrophy and heart failure in renal patients.

Selected Publications

Kang PM, Haunstetter A, Aoki H, Usheva A, Izumo S. Morphological and molecular characterization of reoxygenation-induced adult cardiac myocyte apoptosis. Circ Res 2000;87:118-125.
Kong SW, Bodyak N, Yue P, Liu Z, Brown J, Izumo S, Kang PM. Genetic expression profiles during physiologic and pathologic hypertrophy and heart failure in rats. Physiol Genomics 2005; 21:34-42.
Han Y, Chen YS, Liu Z, Bodyak N, Rigor DL, Bisping E, Pu WT, Kang PM. Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. Circ Res 2006; 99:415-423.
Siu PM, Bae S, Bodyak N, Rigor D, Kang PM. Response of caspase-independent apoptotic factors to high salt diet-induced heart failure. J Mol Cell Cardiol 2007; 42:678-686.
Bodyak N, Ayus JC, Achinger S, Shivalingappa V, Ke Q, Chen YS, Rigor DL, Stillman I, Tamez H, Kroeger PE, Wu-Wong RR, Karumanchi A, Thadhani R, Kang PM. Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals. Proc Natl Acad Sci USA 2007; 104:16810-5.

Current Research Funding

2008-2010 Role of doxercalciferol in cardiac hypertrophy Pharmaceutical contract/Genzyme
The goal of this project is to examine the anti-hypertrophic potential of an activated vitamin D compound, doxercalciferol, in cardiac hypertrophy.

2009-2011 Apoptosis inducing factor in cardiac apoptosis
NHLBI/R01 HL091998
The major goal is to elucidate the molecular mechanism of AIF in cardiac
apoptosis using in vitro and in vivo models.

2009-2011 Role of vitamin D after myocardial infarction ExtenD Research Program/Abbott
The major goal of this project is to study the role of activated vitamin D on
cardiac remodeling after experimental myocardial infarction.

2009-2014 World Class University Program
Korean Education and Science Ministry
Foreign Scholar/PI (Project Director – Khang)
The goal is to develop research collaborations in the biomedical/bioengineering
program at Chonbuk National University.

2010-2011 Vitamin D and heart failure
CeDAR Research Program
Massachusetts General Hospital
The goal of this project is to study the role of vitamin D therapy in attenuating the progression to heart failure.

2008-2013 Soluble endoglin in the pathogenesis and prediction of preeclampsia
Burrough-Wellcome Fund
Co-investigator (PI-Karumanchi)
The major goal of this project is to study the cardiovascular effects of soluble
endoglin in a model of preeclampsia.

2009-2012 Mechanisms of misfolded protein toxicity in idiopathic dilated cardiomyopathy NHLBI/R21 HL102716
Co-investigator (PI-del Monte)
The major goal is to examine the mechanism for the pathogenic effect of protein oligomers in models of idiopathic dilated cardiomyopathy in human and mice.