Paul C. Leavis, PhD

Paul C. Leavis, PhD

Adjunct Professor, Department of Health Sciences
Programs in Human Physiology
635 Commonwealth Ave
1966 BS University of Notre Dame (Biology)
1971 PhD Tufts University Graduate School of Arts and Sciences (Physiology)

Scholarly Interests

Peptide inhibitors of leptin signaling in normal and abnormal cellular function, protein and peptide chemistry

Selected Publications

Tao, T., Gong, B.L. and Leavis, P.C., Troponin I as a molecular switch in skeletal muscle regulation, Science, 247; 1339-1340, 1990.

Coppin, C.M. and Leavis, P.C., Quantitation of liquid crystalline ordering in F-actin solutions, Biophys. J. 63; 794-807, 1992

Wu, Q.-L., Raychowdhurey, M.K., Du, Y., Jha, P.K., Leavis, P.C. and Sarkar, S., Characterization of a rabbit fast troponin I cDNA: A comparative sequence analysis of vertebrate isoforms and tissue-specific expression of a single copy gene., DNA Sequence-J. DNA Sequencing and Mapping, 4; 113-121, 1993.

Wu, Q-L., Jha, P.K., Raychowdhury, M.K., Du, Y., Leavis, P.C. and Sarkar, S., Isolation and characterization of human fast skeletal  Troponin T cDNA: Comparative sequence analysis of isoforms and insight into the evolution of members of a multigene family, DNA and Cell Biology, 13; 217-233, 1994.

Jha, P.K., Du, Y., Wu, Q.-L., Leavis, P.C. and Sarkar, S., Overexpression and rapid purification of rabbit fast skeletal troponin I from escherichia coli: Effect of different promoters, host strains, and culture conditions, Protein Expression and Purific. 5; 604-613, 1994

Kobayashi, T., Leavis, P.C. and Collins, J.H., Interaction of a troponin I peptide with both domains of troponin C, Biochem. Biophys. Acta. 1294; 25-30 (1996)

Liu, R., Leavis, P.C., Badwey, J.A., In vitro activation of a 60-70 kDa protein kinase from neutrophils by limited proteolysis, Biochim. Biophys. Acta. 1295; 89-95 (1996)

Jha, P.K., Leavis, P.C., Sarkar, S., Interaction of delection mutants of TroponinsI and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca2+ sensitivity of the reconstituted regulatory system., Biochemistry 35; 16573-16580 (1996)

Roussev, R., Coulam, C.B., Kaider, B.D., Yarkoni, M., Leavis, P.C., Barnea, E.R., Embryonic origin of preimplantation factor (PIF): biological activity and partial characterization., Molec. Human Reprod. 2; 883-887 (1996)

Leinweber BD, Leavis PC, Grabarek Z, Wang C-L, Morgan KG. ERK interaction with actin and the CH domain of actin binding proteins. Biochem. J. 344(1):117-123 (1999).

Taggart, M. J., Leavis, P.C., Feron, O., and Morgan, K. Inhibition of PKC and rhoA translocation in differentiated smooth muscle by a caveolin scaffolding domain peptide, Experimental Cell Res. 258: 72-81 (2000).

Leinweber, B., Parissenti, A. M., Gallant, C., Gangopadhyay, S.S., Kirwan-Rhudes, A., Leavis, P.C., and Morgan, K.M. Regulation of protein kinase C by the cytoskeletal protein calponin., J. Biol. Chem. 275: 40329-40336, 2000.

Gonzalez, R. R. and Leavis, P.C.. Leptin upregulates -3 integrin expression and interleukin-1 upregulates leptin and leptin receptor expression in human endometrial epithelial cell cultures. Endocrine, 16; 21-28, 2001

Uzzo, R. G., Leavis, P.C., Hatch, W., Gabai, V. L., Dulin, N., Zvartau, N. and Kolenko, V. M., Zinc inhibitis nuclear factor-kappabeta activation and sensitizes trostate cancer cells to cytotoxic agents, Clinical Cancer Research 8; 3579-3583 (2002)

Gonzalez, R.R., Leary, K., Petrozza, J.C. and Leavis, P.C., Leptin regulation of the interleukin-1 system in human endometrial cells, Molecular Human Reproduction 9;151-158 (2003)

Gonzalez, R. R. and Leavis, P.C., A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells, Endocrine 21; 185-195 (2003)

Je, H. D., Gallant, C., Leavis, P.C., Morgan, K. G. Caveolin-1 Regulates Contractility in Differentiated Vascular Smooth Muscle. Am J Physiol Heart Circ Physiol 286: H91-H98 (2004).

Gonzalez RR, Rueda BR, Ramos MP, Littell RD, Glasser S, Leavis, P.C., Leptin-induced increase in leukemia inhibitory factor and its receptor by human endometrium is partially mediated by interleukin 1 receptor signaling. Endocrinology. 2004 Aug;145(8):3850-7

Ramos MP, Rueda BR, Leavis, P.C, Gonzalez RR., Leptin serves as an upstream activator of an obligatory signaling cascade in the embryo-implantation process. Endocrinology. 2005 Feb;146(2):694-701

Kim, H.R., Gallant, C., Leavis, P.C., Gunst, S.J. and Morgan, K.G. Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform-dependent and stimulus-dependent. Am J Physiol Cell. Accepted for publication.

Current Research Funding

  • National Institutes of Health
  • National Heart Lung and Blood Institute
  • Program Project Grant (HL 1PO1HL086655-01A1)
  • Director of Protein Peptide Core Facility
  • Principal investigator Kathleen Morgan
  • Dynamics of the Vascular Smooth Muscle Cytoskeleton
  • Duration: 07/10/2007-07/10/2012
  • Cancer Research UK
  • Discovery Award: “Optimization of leptin receptor antagonist peptides (LPA) and studies on bioavailability and efficacy in a tumor model”
  • Principal Investigator: Paul Leavis
  • Duration: 1/1/08-12/31/09

Awards and Honors

  • Established Investigator of American Heart Association 1978-1983
  • 2000 Dean’s Award for Excellence in Basic Science Teaching, Tufts Dental School
  • Award for “Outstanding Contribution to Graduate Studies” 2006, Tufts University Graduate School of Arts and Sciences.