- Additional Titles:Programs in Human Physiology
- Education:BA (Anthropology-Zoology), University of Michigan
MS (Kinesiology), University of Michigan,
PhD (Physiology), University of Michigan Medical School
Scholarly, Research, and/or Practice Interests
- My research program uses a variety of thermoregulatory, behavioral, and metabolic approaches to understand the pathophysiological mechanisms that mediate heat stroke morbidity / mortality. The primary focus of my research is to identify tissue-specific inflammatory pathways that mediate organ damage with the hope of discovering novel pharmacologic treatments to aid in recovery.
HS 750 Analysis of Physiological Literature
Leon LR and Helwig BW. Heat stroke: role of systemic inflammatory response. J. Appl. Physiol., 2010 (in press).
Leon LR, Gordon CJ, Helwig BG, Rufolo DM, and Blaha MD. Thermoregulatory, Behavioral, and Metabolic Responses to Heat Stroke in a Conscious Mouse Model. Am. J. Physiol., 2010 (in press).
Leon LR. Heat stroke and cytokines. Prog. Brain Res. 162: 481-524, 2007.
Leon LR, Blaha M, and Dubose DA. Time course of cytokine, corticosterone and tissue injury responses in mice during heat strain recovery. J. Appl. Physiol. 100: 1400-1409, 2006.
Leon LR, DuBose DA, and Mason CD. Heat stress induces a biphasic thermoregulatory response in mice. Am. J. Physiol. 288: R197-R204, 2005
Leon LR, DuBose DA, and Walker LD. Editorial Focus: Biotelemetry transmitter implantation in rodents: impact on growth and circadian rhythms. Am. J. Physiol. 286: R967-R974, 2004.
- Defense Medical Research and Development Program, “Efficacy of novel pharmacologic treatments for heat injury / stroke Return-to-Duty,” Principle Investigator.