Susan Kandarian, Ph.D.
Professor, Department of Health Sciences, Sargent College, Boston University
Research Assistant Professor, Department of Physiology, Boston University School of Medicine
Research Associate Professor, NeuroMuscular Research Center, Boston University
Molecular Biology, Cellular Biology & Biochemistry (MCBB) interdepartmental doctoral program, Boston University
Phone: 617-353-5169
Email: skandar@bu.edu
Website: www.bu.edu/kandarian
CURRICULUM VITAE
Education
| 1981 | B.A., Albion College, Albion, MI, Biology major (Cum Laude) |
| 1983 | M.S., The University of Michigan, Ann Arbor, Department of Kinesiology |
| 1988 | Ph.D., The University of Michigan, Ann Arbor, Department of Kinesiology, Field of Study: Muscle Biology |
| 1989-1992 | Postdoctoral experience, trained with Dr. Javier Navarro at Boston University School of Medicine while Assistant Professor of Health Sciences, Boston University, see publications) |
Courses Taught
- Molecular Physiology of Muscle, 1995, 1996, 1997, 1998
- Cellular Exercise Physiology, 1993, 1994, 1995
- Cardiopulmonary Pathophysiology, 1988, 1989, 1990, 1991
- Advanced Anatomy & Physiology I, 1989,
- Advanced Anatomy & Physiology II, 1989
- Human Physiology for Allied Health Professions, 1989
- Physiology of Exercise, summer 1989,
- Muscle Physiology, 1990, 1991, 1992
Scholarly Interests
Work in my laboratory primarily focuses on understanding the pathways that mediate skeletal muscle atrophy using cellular and molecular approaches. Most recent work is on the role of NF-kappaB pathways in regulating atrophy in disuse and cachectic conditions. Studies are geared towards identifying genes that are necessary or sufficient for the induction and progression of atrophy.
Selected Publications
Koncarevic A, Jackman RW, Kandarian SC. The ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced muscle tension. Faseb J. 21(2):427-37, 2007.
Judge AR, Koncarevic A, Hunter RB, Liou HC, Jackman RW, Kandarian SC, Role for IB, but not c-Rel, in skeletal muscle atrophy. Am J Physiol Cell Physiol. 292(1): C372-82, 2007.
Kandarian, S.C. and R.W. Jackman. Intracellular signaling during skeletal muscle atrophy. Muscle Nerve. 2006; 33; 155-165.
Kandarian, S.C. Large scale gene expression profiles as tools to study skeletal muscle adaptation. Chapter 2, in, Skeletal Muscle Plasticity in Health and Disease: From Genes to Whole Muscle. Eds. C. Reggiani and R. Bottinelli, Springer:New York, 2006.
Stevenson, E.J., A. Koncarevic, P.G. Giresi, R.W. Jackman, and S.C. Kandarian. The transcriptional profile of a myotube starvation model of atrophy. J Appl Physiol., 98(4):1396-406, 2005.
Giresi, P.G., E.J. Stevenson, J. Theilhaber, A. Koncarevic, J. Parkington, R.A. Fielding, and S. C. Kandarian. Identification of a molecular signature of sarcopenia. Physiol. Genomics 21(2):253-63, 2005.
Hunter, R.B. and S.C. Kandarian. Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. J Clin Invest. 114(10):1504-1511, 2004.
Jackman, R.W. and S.C Kandarian. The molecular basis of skeletal muscle atrophy. Am J. Physiol. Cell Physiol. 287: C834-C843, 2004.
Stevenson, E.J. and S.C. Kandarian. Gene expression profiling shows its muscle. Physiology News. 54: 24-25, 2004.
Selected Presentations
Invited research seminar at the University of Florida, Program in Kinesiology, entitled, “Progress in Understanding the Control of Muscle Atrophy” April 19, 2007.
Presentation of research at Experimental Biology Meeting in Symposium entitled, “Cellular and Molecular Signals Regulating Plasticity of Skeletal Muscle Fiber Type and Size.” Talk was entitled, “Signaling mechanism in skeletal muscle atrophy.” April 1-5, 2006, San Francisco, CA.
Presentation of research at Beth Israel Deaconess Medical Center, Harvard Medical School, Department of Surgery. Title of presentation: “The role of NF-kappaB signaling in skeletal muscle atrophy.” Host: Per-Olof Hasselgren, Professor of Surgery, BIDMC, Boston, MA, February 24, 2006.
Presentation of research at the International meeting, the 3rd Cachexia Conference, “Disuse atrophy vs. muscle wasting,” Angelicum Congress Centre, Rome, Italy, December 8-10, 2005
Presentation of research at the S. Mouchly Small Muscle Symposium – Mechanisms of muscle atrophy. Title of talk, “Intracellular signals in disuse muscle atrophy.” Host: Priscilla Clarkson, University of Massachusetts Amherst, June 24-25, 2004.
Presentation of research at Boston University’s Biomolecular Seminar Series, “The Molecular Basis of Skeletal Muscle Atrophy.” Host: Chip Celenza, Boston, MA, February 9, 2004.
Presentation of research at the National Space Biomedical Research Institute Investigator Retreat, “Production of Adenoviral Expression Vectors to Study the Role of Proteolytic Genes in Muscle Atrophy.” Del Lago Conference Center, Montgomery, TX, Jan 12-14, 2004.
Research Funding
As Principal Investigator (or Mentor):
| 2007-2012 | National Institutes of Health, R01 AR41705 |
| 2007-2009 | National Institutes of Health, R21 AR054446 |
| 2006-2009 | National Institutes of Health, F32 AR054265, post-doctoral fellow award to Darin VanGammeren (NRSA) |
| 2006-2007 | Boston University Provost’s SPRInG Award – Intramural |
| 2004-2007 | National Aeronautics Space Administration, NNA04CD02G |
| 2004-2006 | National Space Biomedical Research Institute, post-doctoral fellow award to Andrew Judge (PF00501) |
| 2002-2007 | National Institutes of Health, R01 AR41705 |
| 2002-2004 | National Institute of Health, R21 AG019754 |
| 2001-2004 | National Space Biomedical Research Institute, Muscle atrophy and alterations team (00-NSBRI-01-038) |
| 2000-2003 | National Aeronautics Space Administration, pre-doctoral stipend award to Eric Stevenson (NGT5-50307) |
| 1997-2000 | National Institutes of Health, R01 AR41705 |
| 1995-2000 | National American Heart Association, Established Investigator Award (salary award) |
| 1995-1998 | National American Heart Association, Grant-in-Aid Award |
| 1995-1996 | National Aeronautics and Space Administration |
| 1992-1996 | National Institutes of Health, R29 AR41705 |
| 1992-1994 | American Heart Association-Massachusetts Affiliate, Grant-in-Aid |
| 1991-1992 | Boston University Biomedical Seed Grant |
| 1989-1990 | American College of Sports Medicine Foundation Grant |
| 1989 | Boston University Biomedical Seed Grant |
Consulting and Professional Activities
| 1992-present | American Association for the Advancement of Science (Member) |
| 1990-present | American Physiological Society (Member) |
| 1982-2003 | American College of Sports Medicine (elected to Fellow status 1992) |
| 2001-2005 | Member of the American Physiological Society Porter Physiology Development Committee (review grant applications for PhD minority students) |
| 1999-2003 | Resident Agent of Massachusetts for the International Society for Heart Research |
| 1994-2000 | American College of Sports Medicine, Research Review Committee (yearly grant review) |
| 1992-1997 | Appointed/ served as Liaison to the Molecular, Cellular, & Regulatory Mechanisms interest group of the American College of Sports Medicine (meets yearly) |
Honors
| 1995-2000 | Established Investigator Award, American Heart Association |
| 1999 | University of Michigan, Alumni Achievement Award |
| 1995 | Sargent College Faculty Merit Award for Outstanding Professional Service |
| 1988 | Dissertation of the Year Award, University of Michigan |
| 1985 | University of Michigan, Rackham Graduate School Doctoral Research Award |
| 1981 | Elected to Beta Beta Beta Biology Honorary, 1981 |
Academics
Also See
