Institutional Biosafety Committee

To complete the renewal, PIs should list all proposed modifications from the protocol as initially approved (or since the last renewal notice), including:

• any changes in laboratory location or equipment
• changes in laboratory staff working on the project
• any project titles to be added
• any agent or experimental changes

If there are significant modification from the protocol, especially those that affect the containment level (i.e., new study on organisms, a new host-vector-donor system, or any other modifications that may affect the containment level), the IBC will send the protocol for committee review and approval.

When a project is renewed, the PI and all lab staff must complete the Lab Safety Annual Refresher Training requirement, the annual Research Occupational Health Program (ROHP) clearance (contact ROHP at rohp@bu.edu; 617-414-7647), and any other training requirements applicable to the project.

For changes in PI, the new PI must attach two-page NIH biosketch to the renewal form. This must be reviewed by the full committee.

The IBC Office will notify you when your Annual Renewal has been processed and approved. IBC approval is required before any changes in the work can commence.

1. Complete the IBC annual renewal in RIMS (see instructions below) and click “confirm the submission” to send it to the IBC Office for renewal evaluation.
2. Make sure the PI and all lab staff complete the annual EHS Lab Safety Training requirement , the annual Research Occupational Health Program (ROHP) clearance update (contact ROHP at 617-414-7647), and any other applicable training requirements.The exact training required for a particular person will depend on the hazards to which he or she is exposed.
3. The IBC Office will notify you when your annual renewal has been processed and approved. IBC Approval is required before any changes in the work can commence.

1. Log in to RIMS.
2. Under Activities and Authorizations in the left menu, click on Biological Use Authorization – IBC Application.
3. Click on the blue-underlined project title of your IBC protocol due for annual renewal.
4. In the left menu, click the blue links in sequence up to the Grant Funding Information page.
5. Check the radio button for Annual Renewal. Summarize any updates/changes to your protocol in 1-2 sentences in the text box.
   • Example: “Addition of graduate student John Doe; removal of departing visiting scientist; move of laboratory space (coordinated with EHS); change in host-vector-donor system; addition of virus strains”
6. On the bottom of the Grant Funding Information page, click on Save Changes.
7. Click to the Dual Use Research of Concern page to review the questions and confirm your answers. If you make any changes, click Save Changes at the bottom of the page.
8. Update any of the other application pages/sections with the relevant information regarding any changes or updates in your IBC protocol.
9. After all changes are complete and saved, click on “Confirm the Submission” to send the Annual Renewal update to the IBC Office.

On the Personnel page, delete and add personnel as appropriate.

To delete a person

1. Select that person by clicking the “+” next to their name in the table at the top of the page.
2. Click the “Delete” button at the bottom of the page to remove them from the protocol.

To add a person

1. Click the “Add Personnel” button at the bottom of the page.
2. Complete questions on training and experience.
3. If a person has been entered into the PI Profile when you first log in to RIMS (highly recommended), you may click the “Select personnel from your PI list” button to add that person.

On the Research Laboratory Facility Information page, delete and add research spaces as appropriate, including all facilities used for the project.

To delete a location

1. Select the location by clicking the “+” next to its name in the table at the top of the page.
2. Click the “Delete” button at the bottom of the page to remove it from the protocol.

To add a location

1. Click the “Add Research Laboratory Location” at the bottom of the page.
2. Complete all subsequent questions.
3. Be sure to update the Biological Safety Cabinet information/certification on the Personal Protective Equipment/Safety Equipment page, if applicable.

Amendments must be submitted to the IBC for approval of changes within an approved project. All changes should be described in detail, and these must be reviewed and approved by the IBC according to the table below. IBC approval is required before any changes in the work can commence.

For all IBC Protocols, complete the Amendment in RIMS and confirm the submission to send it to the IBC Office for amendment evaluation.

The IBC Office will notify you when your Amendment has been processed and approved. IBC approval is required before any changes in the work can commence.

1. For all IBC Protocols, complete the Amendment in RIMS and click confirm the submission to send it to the IBC Office for amendment evaluation (as either an expedited or a reviewable amendment).
2. Make sure lab staff complete the annual EHS Lab Safety Training requirement.
   • Contact the Research Occupational Health Program (ROHP) for medical clearance (617-414-7647).
   • Complete any other applicable training requirements.
3. The IBC Office will notify you when your Amendment has been processed and approved. IBC Approval is required before any changes in the work can commence.

1. Log in to RIMS.
2. Under Activities and Authorizations in the left menu, click on Biological Use Authorization – IBC Application.
3. Click on the blue-underlined Project Title of your IBC Protocol that you wish to amend.
4. In the left menu, click the blue links in sequence up to the Grant Funding Information page.
5. Check the radio button for Amendment, and summarize any updates or changes to your protocol in 1-2 sentences.
   • Example: “Addition of graduate student John Doe; removal of departing visiting scientist; move of laboratory space (coordinated with EHS); change in host-vector-donor system; addition of virus strains”
6. On the bottom of the Grant Funding Information page, click Save Changes.
7. Update any of the other application pages and sections with the relevant information regarding changes or updates in your IBC protocol.
8. After all changes are complete and saved, click Confirm the Submission to send the Amendment to the IBC Office.

On the Personnel page, delete and add personnel as appropriate.

To delete a person

1. Select that person by clicking the “+” next to their name in the table at the top of the page.
2. Click the “Delete” button at the bottom of the page to remove them from the protocol.

To add a person

1. Click the “Add Personnel” button at the bottom of the page.
2. Complete questions on training and experience.
3. If a person has been entered into the PI Profile when you first log in to RIMS (highly recommended), you may click the “Select personnel from your PI list” button to add that person.

On the Research Laboratory Facility Information page, delete and add research spaces as appropriate, including all facilities used for the project.

To delete a location

1. Select the location by clicking the “+” next to its name in the table at the top of the page.
2. Click the “Delete” button at the bottom of the page to remove it from the protocol.

To add a location

1. Click the “Add Research Laboratory Location” at the bottom of the page.
2. Complete all subsequent questions.
3. Be sure to update the Biological Safety Cabinet information/certification on the Personal Protective Equipment/Safety Equipment page, if applicable.