Faculty Research & Labs
PETER BLAKE (Developmental Science)
Ed.D., Harvard University
Our research focuses on how children come to understand the social world. We conduct cognitive and behavioral experiments with children from 2 to 12 years of age. We study things such as cooperation and competition, ownership and private property, fairness and other social norms, and learning through imitation and communication.
LESLIE BRODY (Clinical)
Ph.D., Harvard University
I am interested in gender differences in emotional functioning and how cultural and family socialization contributes to such differences. I am also interested in the relationship between emotional expressiveness and mental and physical health. My current research focuses on how psychosocial predictors (such as coping strategies and gender roles) predict physical and mental health outcomes in women with HIV (such as depression, quality of life, and immune functioning) using both qualitative and quantitative methods, including analyzing autobiographical narratives.
TIMOTHY BROWN (Clinical)
Psy.D., Virginia Consortium for Professional Psychology
Statistical analysis and research methodology (e.g., clinical research applications of new latent variable analytic methods); classification of anxiety and mood disorders; vulnerability/temperament/personality in the development, course, and treatment outcome of emotional disorders; experimental psychopathology research on anxiety/mood disorders; psychometric evaluation and test/interview development.
S. BARAK CAINE
Ph.D., University of California San Diego
My research focuses on two principal areas: (1) pharmacological mechanisms underlying stimulant-induced arousal and stimulant drug abuse (mentor: George F. Koob), and (2) neural mechanisms underlying stimulant-induced psychosis and antipsychotic drug actions (mentors: M.A. Geyer, N.R. Swerdlow). Psychomotor stimulant drugs including cocaine, amphetamine and methamphetamine increase synaptic levels of several monoamine neurotransmitters, and the transporter and receptor proteins involved are highly diverse. For example, the single neurotransmitter dopamine engages five different g-protein coupled receptors. My efforts are directed toward identifying the roles of different transporters and receptors in mediating the abuse-related and psychoses-related effects of stimulant drugs. Ongoing investigations focus on brain dopamine systems. Recent new areas focus on acetylcholine including muscarinic receptors and nicotine. A principal strategy is to push young investigators in my laboratory to introduce and persuade me toward new scientific directions.
CATHERINE CALDWELL-HARRIS (Brain, Behavior, and Cognition)
Ph.D., University of California, San Diego
Students are invited to join me in investigating foreign language acquisition, bilingualism and cross-cultural psychology. Special projects for the current year are understanding jokes in a foreign language, how deaf children learn to read, differences between reading Chinese vs. English, and how Russian immigrants to the US learn English. Students who speak Mandarin or Russian can use their bilingualism skills in ongoing projects.
CHANDRAMOULI CHANDRASEKARAN (Brain, Behavior, and Cognition)
Ph.D., Princeton University
My lab conducts research to better understand how the brain processes complex uni and multisensory input and generates the appropriate action at the right time, a process called decision-making. To study the neural basis of decision-making, we use a combination of electrophysiological, behavioral, modeling, and computational techniques. Specifically, we use a ‘dynamical system’ theoretical framework combined with measurements of activity of populations of neurons using linear multi contact electrodes and utah arrays in animals performing decision-making tasks. By analyzing the average, single trial activity patterns, and differences in neuronal properties across the lamina of cortex, and modeling it with state-of-the-art recurrent neural network models we hope to understand the computational and circuit mechanisms by which the brain guides decisions. My research is guided by the ethos that understanding how decisions emerge in the brain will ultimately help us build better interventions for people with disabilities involving the nervous system. I expect my research career to aid translational efforts that use circuit level treatments and brain machine interfaces for patient populations.
JAMES CHERRY (Brain, Behavior, and Cognition)
Ph.D., North Carolina State University
My research examines the cellular mechanisms underlying cognitive and sensory processes. Our primary interest is to define the functional significance of anatomically distinct chemosensory systems in the mouse, with the overall goal of understanding how odors can influence mammalian reproductive behavior.
ALICE CRONIN-GOLOMB (Brain, Behavior, and Cognition; Clinical)
Professor and Director of Graduate Studies
Ph.D., California Institute of Technology
My main areas of interest are: (1) the relation between vision, perception, cognition, gait, and other aspects of daily function in normal aging and in neurodegenerative disease; in particular, visual cognition in Parkinson’s disease (PD); (2) the neural circuitry of perception and cognition in PD; (3) methods to improve cognition in PD, including at-home attentional training and in-lab assessments. We conduct basic research as well as intervention studies in collaboration with investigators at Sargent College and the Boston VA. Some individual student-led projects on PD include studies of the relation of motor to non-motor symptoms (such as the cost of cognitive-motor dual-tasking) and the relative functional integrity of two visual systems. In addition, we collaborate on BUSM-affiliated Framingham Heart Study projects relating neuropsychological function to markers of physical function, such as hypertension and white matter integrity, and on projects based at BUSM and at the Massachusetts General Hospital on biomarkers and function in Alzheimer’s disease.
MARGARET A. HAGEN (Brain, Behavior, and Cognition)
Ph.D., University of Minnesota
My current interest revolves around determining what kind of biases, prejudices and assumptions jurors bring to trials involving “psychological torts” like the Intentional Infliction of Emotional Distress, Defamation and Invasion of Privacy. I am especially interested in trying to assess the effect on jurors’ decision of “extra-legal” assumptions and beliefs about major societal issues of the day. In our lab, we have created a Civil Juror Bias Scale to help predict whether a potential juror is likely to decide for the plaintiff bringing the suit or for the defendant who has been accused of causing the injury. We are currently starting a new study to apply our Bias Scale to a real world scenario involving an accident between a student on a bicycle and a student pedestrian.
MICHAEL E. HASSELMO (Brain, Behavior, and Cognition)
Professor; Director, Center for Systems Neuroscience
D.Phil., University of Oxford, England
Research in my laboratory concerns the coding of space and time by cortical neurons for episodic memory function, and the regulation of network oscillatory dynamics by neuromodulators such as acetylcholine. Neurophysiological techniques are used to analyze the representation of space and time by cortical neurons including grid cells, head direction cells, and boundary vector cells, and to analyze the local effects of neuromodulation on synaptic and neuronal activity in cortical circuits. Computational modeling at the cellular and network level is used to link the physiological data to behavioral function. Areas of focused research include episodic memory function, memory-guided spatial behavior, and theta rhythm dynamics in hippocampal formation and entorhinal cortex. Research addresses physiological effects relevant to Alzheimer’s disease, schizophrenia and depression.
STEFAN G. HOFMANN (Clinical)
Ph.D. University of Marburg, Germany
My primary research interests are in the treatments and psychophysiology of anxiety and other emotional disorders. Specifically, I am interested in the mechanism of treatment change and the factors that predict treatment success. I am also interested in the biological correlates of different emotional states.
MARC HOWARD (Brain, Behavior, and Cognition)
Professor; Brain, Behavior, and Cognition Program Director
Ph.D., Brandeis University
Research investigates topics centered on episodic memory, the ability to remember specific events situated in a particular spatiotemporal context. We develop mathematical models of cognition and evaluate them against both behavioral and neurophysiological data, providing a bridge between cognition and systems-level neuroscience. We use a combination of mathematical, computational and behavioral tools to evaluate our hypotheses. At present, our efforts are focused on developing and evaluating a unified mathematical framework to describe how the brain constructs the spatial and temporal context believed to underlie episodic memory. This model appears to have far-ranging implications, leading to research interests in statistical learning, semantic memory, time perception, and reward systems.
MARK HOWE (Brain, Behavior, and Cognition)
Ph.D, Massachusetts Institute of Technology
The goal of my laboratory is to identify neural circuit principles responsible for adaptively motivating, selecting, and learning actions in changing environments. We focus on the basal ganglia, a set of brain regions implicated in regulating motor and cognitive functions on multiple timescales. A range of techniques are employed including two-photon microscopy, fiber photometry, and electrophysiology in behaving mice as they perform tasks in virtual environments. These approaches enable us to investigate neural computations at multiple spatial scales, from large scale networks to subcellular compartments of single neurons. Basic principles derived from these studies can be applied to better understand neural disorders of the basal ganglia such as Parkinson’s and Huntington’s Disease.
KATHLEEN KANTAK (Brain, Behavior, and Cognition)
Ph.D., Syracuse University
My research uses animal models to conduct translational research related to drug addiction, attention deficit hyperactivity disorder and their co-morbidity. Using intravenous drug self-administration procedures in rats, I investigate how multiple memory systems regulate drug-seeking and drug-taking behavior as well as how drug exposure influences the neurocognitive functioning of multiple memory systems. In addition, I investigate how cognitive-enhancing therapeutics may be useful to facilitate extinction learning for drug-conditioned cues and attenuate drug relapse. Other studies focus on evaluating the frontostriatal and medial temporal lobe neurocognitive deficits in rats with an ADHD phenotype and their response to medications as well as comorbidity between ADHD and vulnerability to drug addiction. In the context of all this research, I collaborate with other investigators to conduct neurochemical analyses to determine molecular correlates of these disorders and their treatment.
DEBORAH KELEMEN (Developmental Science)
Ph.D., University of Arizona
Research in the Child Cognition Lab focuses on cognitive development. Our studies explore conceptual influences on intuitive, religious, and scientific theory-formation, object categorization, social and moral cognition, sociocultural and individual differences in cognition, and the development of children’s causal and purpose-based reasoning about the natural world. A significant emphasis of current work is the application of basic cognitive developmental research to elementary STEM education.
MELISSA M. KIBBE (Developmental Science)
PhD, Rutgers University
The world is rich with information, but our brains process and store only a small fraction of the information available. How do we decide which information we should keep track of, and how do we store and use this information efficiently? My research focuses on how infants, children, and adults represent objects and people, the kinds of computations they can do with those representations, and how they use that information to guide behavior. I also look at how cognitive systems (such as working memory, attention, social cognition, and decision-making) interact during complex tasks. My research relies on both behavioral methods and computational modeling of cognitive processes.
SAM LING (Brain, Behavior, and Cognition)
Ph.D., New York University
Sensation is easy—even a camera can sense light. For a camera, light simply falls onto film, creating a photograph of what was seen; the story ends there. For humans, however, the moment light falls on our retina is but the beginning of an exceedingly complex process, culminating in our rich perceptual experiences. It is this remarkable process that sets our visual system far apart from simple devices such as cameras: our brain’s ability to perceive and consciously experience the visual world. My lab’s work centers on that pivotal stage of cognitive processing—the stage at which sensation becomes perception. My research combines a variety of techniques, including psychophysics, computational modeling, and functional magnetic resonance imaging (fMRI)—all aimed towards understanding how the brain mediates between the ‘buzzing confusion’ of the visual environment and our limited processing power.
KRISTIN LONG (Clinical)
Ph.D., University Pittsburgh
My research focuses on (1) reciprocal influences between a person’s medical illness or disability and his/her family and cultural context, (2) health disparities in autism diagnosis and treatment, and (3) the development and evaluation of psychosocial interventions for individuals with chronic conditions and their families. The majority of my work is carried out within the context of cancer (childhood) and autism (across the lifespan).
MICHAEL J. LYONS (Clinical)
Professor and Chair ad interim
Ph.D., University of Louisville
My general interests are in the areas of psychiatric and behavioral genetics and psychiatric epidemiology. My research focuses on how genetic factors (and environmental factors) influence psychopathology and other aspects of behavior. My current research primarily involves twin studies of aging, personality disorders, PTSD, and substance abuse, especially nicotine and alcohol.
JOSEPH MCGUIRE (Brain, Behavior, and Cognition)
Ph.D., Princeton University
My group conducts basic research on decision making. Our goal to understand the information processing operations that enable people to make good decisions in uncertain environments. We study how people decide what future rewards to pursue and how long to persist in the face of setbacks. Our methods include behavioral experiments, computational modeling, psychophysiology, and neuroimaging.
MICHAEL OTTO (Clinical)
Ph.D., University of Mexico
My research focuses on the investigation of the etiology and treatment of anxiety, mood, and substance-use disorders. Of particular interest to me is the development and testing of new treatments, including the combination of pharmacologic and cognitive-behavioral strategies for treatment-refractory and substance abusing patients. In addition, I am pursuing a number of translational research agendas, examining potential mediators and moderators of the efficacy of exposure-based treatments, as well as novel approaches for the promotion of health behaviors, including the role of exercise in treating mood and anxiety disorders.
TIBOR PALFAI (Clinical)
Professor; Clinical Program Director
Ph.D., Yale University
My primary research interest is the role of cognitive-motivational processes in health risk behavior, including problem drinking, smoking, and eating. Specific areas of research include, (1) understanding the processes underlying successful and failed self-control attempts and (2) developing approaches to reduce health-risk behaviors among college student and medical populations.
BRENDA CALDWELL PHILLIPS
Ph.D., Boston University
My research explores the social-cognitive factors that facilitate children’s conceptual development in both formal and informal learning environments. The overarching goal of my research program is to (a) identify the mechanisms that facilitate knowledge acquisition, (Brain, Behavior, and Cognition) examine the influence of emergent intuitive causal explanations on conceptual development and conceptual change, and (Clinical) identify empirically-based intervention strategies for school and community-based programs. Most recently my interests have culminated in an applied research program dedicated to fostering children’s understanding of evolution and biological conservation.
DONNA B. PINCUS (Clinical)
Ph.D., SUNY Binghamton
My primary research interests include the assessment and treatment of children’s fears and anxieties; children’s coping with everyday stress; risk and resilience factors affecting the development of child psychopathology; and psychological factors affecting children with medical conditions. My current research focuses on developing new treatments for children and adolescents with anxiety disorders and their families. I am also currently developing treatments for children and adolescents with comorbid conditions, such as anxiety and sleep disorders.
STEVE RAMIREZ (Brain, Behavior, and Cognition)
Ph.D., Massachusetts Institute of Technology
Our research focuses on artificially manipulating and imaging memories in healthy and maladaptive states. Our lab utilizes a breadth of tools to tease out the causal relationship between cellular activity and memory including large-scale imaging technologies, optogenetics and chemogenetics, as well as transgenic and virus-based strategies to identify neuronal ensembles active during learning and recollection.
ROBERT REINHART (Brain, Behavior, and Cognition)
Ph.D., Vanderbilt University
My research examines how the brains of healthy people and those with neuropsychiatric disorders selectively extract, store, and use information from the external world. We employ visual perceptual and cognitive tasks, and noninvasively measure the electrical brain activity and behavior of participants performing these tasks. We also use transcranial electrical stimulation to safely and reversibly manipulate participants’ brain activity and behavior. Active areas of study include visual attention, visual working memory, long-term memory, learning, and cognitive control.
MARK RICHARDSON (Clinical)
Clinical Associate Professor
Ph.D., University of California, Los Angeles
My primary clinical and research interest address neurobehavioral sequelae of a variety of acute and chronic conditions among adults, including: HIV disease, depression, traumatic closed head injury and substance abuse. Current interests also include assessment of cognitive abilities and personality functioning, clinical judgment, and ethnicity and culture as risk- and protective factors in psychopathology.
ANTHONY J. ROSELLINI (Clinical)
Research Assistant Professor
Ph.D., Boston University
My research uses clinical psychological and epidemiological methods to identify and understand emotional (e.g., personality/temperament) and environmental factors (e.g., stress/adversity) that influence the development and persistence of anxiety and depression. My current work involves using machine learning methods to develop optimized prediction tools that identify individuals at risk of anxiety and mood disorder onset and chronicity. I am also interested in improving the assessment and classification of anxiety and mood psychopathology.
KIMBERLY SAUDINO (Developmental Science)
Ph.D., University of Manitoba
My primary research area is infant and child temperament with a focus on activity level. I am particularly interested in etiology of individual differences in the development of temperament, and much of my research involves the study of twins in an effort to disentangle the contributions of genetic and environmental factors to the development of temperament and related behaviors. A second focus of my research is on the measurement of temperament in childhood; specifically, the factors that influence the validity of parents’ ratings of their child’s temperament.
BENJAMIN SCOTT (Brain, Behavior, and Cognition)
Ph.D., Massachusetts Institute of Technology
My research interest is to develop and apply new technologies to study the neural basis of cognition and complex learned behavior. My approach involves a combination of two fields. The first is biomedical engineering, particularly the development of novel optical imaging and genetic methods to observe and perturb the activity of neurons in their native habitat – the intact brains of living organisms. The second is neuroethology, the study of brain circuits that underlie natural behaviors in order to elucidate basic principles of brain function. My current work brings together high-throughput behavioral training with advanced techniques for imaging brain activity in order to identify and characterize the neural circuits involved in evidence-based decision making.
DAVID SOMERS (Brain, Behavior, and Cognition)
Professor and Chair
Ph.D., Boston University
The Neuroimaging, Perception & Attention Laboratory employs functional MRI, psychophysics, and computational modeling to investigate the mechanisms underlying perception, attention & working memory. Our studies focus on basic science questions about the functioning of the normal human brain. We are particularly focused on questions of how we perceive, attend to, and remember multiple objects at the same time. Studies examine perception and cognition in the visual, auditory, and tactile modalities.
CHANTAL E. STERN (Brain, Behavior, and Cognition)
Professor; Director, Cognitive Neuroimaging Center
D. Phil., University of Oxford, England
My lab uses neuroimaging methods coupled with behavioral and computational techniques to examine short-term and long-term memory processes, context-dependent rule learning, and spatial navigation. Basic science work in the lab focuses on the medial temporal lobe and prefrontal cortex, and collaborative work aims to integrate our understanding of how memory interacts with attention and perception. In addition, translational work in the lab focuses on aging, including work on Alzheimer’s disease and Parkinson’s disease and the effects of exercise on brain function.
HELEN TAGER-FLUSBERG (Developmental Science)
Ph.D., Harvard University
My current research focuses on four broad questions in the area of autism/ASD and related neurodevelopmental disorders: (1) What are the early brain and behavioral risk signs for ASD before the onset of the disorder? (2) Can we assess variability in ‘mirror neuron system’ functioning in toddlers and preschoolers with ASD and will a brief targeted intervention lead to changes in both electrophysiological and behavioral markers of the MNS; (3) Why do about one-quarter of all children with ASD fail to acquire spoken language? and (4) Can we develop novel, efficient, language outcome measures that can be used in the context of clinical and interventions trials. These research programs involve collaborations with colleagues at BU and at neighboring universities and all involve a range of methods covering brain and behavioral development.
AMANDA TARULLO (Developmental Science)
Associate Professor; Developmental Science Program Director
Ph.D., University of Minnesota
My research focuses on the effects of early experiences on the neural and behavioral development of infants and young children. In particular, I examine the ways in which early life stress shapes the developing brain as well as the neurodevelopmental mechanisms that link early life stress to child outcomes. Using electroencephalogram (EEG) measures, I identify patterns of infant brain activity that predict socio-emotional and cognitive functioning in early childhood. I study both typically developing and at- risk populations in order to explore both normative and atypical neurodevelopmental processes. One aim of this research is to understand why some children who experience early life stress are resilient and fare quite well, whereas others have enduring developmental problems.
MARTHA TOMPSON (Clinical)
Associate Professor; Master’s Program Director
Ph.D., University of California, Los Angeles
My research focuses on the role of the family in promoting individual mental health. I have examined adults and children with a variety of mental disorders and their families. I am particularly interested in family processes and family treatment among individuals with depression, bipolar disorder and schizophrenia. The goal of this work is to identify strengths and deficits in family systems, which may impact on the course of mental disorders, and to develop programs for helping families cope with theses disorders. My most recent projects include: 1) designing and implementing family-based treatment for preadolescent children with depressive disorders; 2) examining the role of maternal depression and family relationships in the development of depression vulnerability in youth; and 3) understanding the impact of family psychoeducationally-focused treatment for adults with bipolar affective disorder.
NICHOLAS JAMES WAGNER (Developmental Science)
Ph.D., University of North Carolina at Chapel Hill
My research examines the enduring impact of early experiences and relationships (e.g., parent-child relationships, sibling relationships) on children’s social and emotional development. I am particularly interested in the processes through which psychobiological and environmental factors promote psychosocial adaptation or contribute to the emergence of psychopathology. Key to this work is elucidating how young children’s self-regulatory capacities influence associations between early experiences with parents and emotional, cognitive, and social development. One line of ongoing research examines early experiential and biological processes that contribute to later behavioral and emotional problems, with a specific focus on callous-unemotional traits. A second line of research broadens my focus to include anxiety, behavioral inhibition, and social withdrawal. Cutting across the entirety of this program of research is an appreciation for the influence of the social environment (e.g., peer relationships, school contexts) on patterns of biobehavioral adaptation or the emergence of both externalizing and internalizing psychopathology.