Metcalf Professor, Science and Engineering; Dean Emeritus, College of Engineering
Dr. Delisi runs the Bimolecular Systems Laboratory at Boston University that develops and applies computational/mathematical methods, and high throughput experimental methods, to analyze changes in gene and protein expression profiles of cells in response to various endogenous and exogenous signals. In collaboration with the Fraunhofer Center for Manufacturing Innovation, and the Departments of Chemistry and Physics, he and his lab are developing and applying new DNA and peptide microarray technologies for fingerprinting the complete molecular state of a cell. The long range goal is to relate expression patterns to pathways, pathways to networks and networks to function. His current research focuses on the development and application of experimental and computational methods for high throughput genomic and proteomic analysis. Computational methods for determining protein function and the topology of information processing networks Biological applications range from fundamental (e.g. understanding how specific signals are detected, transduced, amplified, processed and stored) to applied; especially to cancer and immune reactions.