OSP FO# 11-220

AGENCY: Department of Health and Human Services (DHHS)/National Institutes of Health (NIH)/Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/National Institute of Dental and Craniofacial Research (NIDCR)/National Institute of General Medical Sciences (NIGMS)/National Institute of Mental Health (NIMH)

PROGRAM: Systems Developmental Biology for Understanding Embryonic Development and the Ontogeny of Structural Birth Defects (R01)

OBJECTIVES: This program provides funding to promote systems developmental biology, an emergent field utilizing the approaches of systems biology to integrate the expanding molecular-level knowledge of genes, proteins, biochemical, biophysical and cellular processes into networks of interacting components that result in embryonic development. Systems developmental biology offers the potential to complement the reductionist focus of modern developmental biology and provide a more comprehensive understanding of the causal relationships leading to normal and abnormal embryogenesis.

Examples of research areas of interest include but are not limited to:

  • Efforts to compile new and to integrate existing data sets regarding signaling pathways, signal transduction cascades, biophysical processes, epigenetic modifications, and transcription factor hierarchies into regulatory network models of developmental processes;
  • Analysis of existing or new data sets to identify connections between genes, pathways, or processes that are involved in developmental processes or the formation of structural birth defects;
  • Experimental validation of network models for developmental processes;
  • Development of computational or experimental tools for constructing, perturbing, and/or validating models of developmental processes;
  • Development of or improvements to computational tools for displaying network models of developmental processes, particularly those that predict outcomes from in silico perturbations.

Projects proposed for this program need not be either hypothesis-driven or experimentally based and can make use of any multicellular model organism. However, these projects should clearly be focused on understanding the processes of embryonic development or the ontogeny of structural birth defects. They should also be based on or useful in furthering approaches that consider how biological components work together to produce system- or network-wide consequences.

DEADLINES: October 4, 2011

FUNDING INFORMATION: This program will utilize the NIH Research Project Grant (R01) award mechanism, and “Just-in-Time” information concepts. R01 funding levels vary according to the scope and need of the project, but cannot exceed a maximum period of 5 years. The number of awards is contingent upon NIH appropriations, and the submission of a sufficient number of meritorious applications.

James N. Coulombe, Ph.D.
Developmental Biology, Genetics and Teratology Branch (DBGT)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
6100 Executive Boulevard, Room 4B01, MSC 7510
Bethesda, Maryland 20892-7510
Telephone: (301) 451-1390
Email: coulombeJ@mail.nih.gov
Web: http://grants.nih.gov/grants/guide/pa-files/PAR-11-257.html

REMARKS: NIH requires that applications to this program be submitted electronically through Grants.gov (http://www.grants.gov). After submission via Grants.gov, applications will be retrieved and processed by the NIH Commons system (https://commons.era.nih.gov/commons/index.jsp). In order to prepare a responsive application, PIs should download both the complete program guidelines (PAR-11-257) and the corresponding application package from Grants.gov as well as the NIH Grants.gov Application Guide (http://grants.nih.gov/grants/funding/424/index.htm). PIs must also be registered Commons users.

For more information about Grants.gov and the NIH Commons, or to register as a Commons user, please contact either India Adams (adamsi@bu.edu) or A. B. Effgen (abeffgen@bu.edu) in the Office of Sponsored Programs (OSP) at x3-4365. In addition, please contact the OSP Assistant Director assigned to your school or department as soon as possible to coordinate submission through the Grants.gov system.

Complete program guidelines and application material may be obtained from the web site listed above or from the Office of Sponsored Programs (OSP). Please distribute this notice to any faculty or staff members who might be interested in the information. For more information, please contact the OSP at X3-4365 or ospinfo@bu.edu, or visit the OSP web site at http://www.bu.edu/osp.